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GENE：U2AF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol U2AF1
FullNmae U2 small nuclear RNA auxiliary factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12453
EnsembleID ENSG00000160201
Uniprot Q01081

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
U2AF1 autophagy 27857975 Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3' tail of ATG7. retulator signature

Go Annotation:

GeneSymbol Go id
U2AF1 GO:0000398,GO:0000398,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005654,GO:0005681,GO:0005681,GO:0005681,GO:0006397,GO:0008380,GO:0015030,GO:0016607,GO:0030628,GO:0046872,GO:0050733,GO:0071013,GO:0089701,GO:0089701,GO:0089701

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
U2AF1 hsa:7307 path:hsa03040 Spliceosome - Homo sapiens (human)
U2AF1 hsa:7307 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EZH2 U2AF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 U2AF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 U2AF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
AP2B1 U2AF1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 U2AF1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 U2AF1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 U2AF1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 U2AF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 U2AF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 U2AF1 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP1 U2AF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 U2AF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC U2AF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004C5774 U2AF1 20371350 21572407 23446348 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MFAP1 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPK U2AF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCAS2 U2AF1 25348397 N/A physical interaction ComPPI
SNW1 U2AF1 20467437 21460037 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CDC5L U2AF1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SAP18 U2AF1 25348397 N/A physical interaction ComPPI
TSNAX U2AF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS7 U2AF1 25348397 N/A physical interaction ComPPI
SNRPA1 U2AF1 25348397 N/A physical interaction ComPPI
RPL37A U2AF1 25348397 N/A physical interaction ComPPI
SNRPD1 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCM5 U2AF1 25348397 N/A physical interaction ComPPI
GABARAPL2 U2AF1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RAN U2AF1 25348397 N/A physical interaction ComPPI
KEAP1 U2AF1 25348397 N/A physical interaction ComPPI
RRS1 U2AF1 25348397 N/A physical interaction ComPPI
EZH2 U2AF1 25348397 N/A physical interaction ComPPI
SF3A2 U2AF1 17332742 24234451 25348397 physical association affinity chromatography technology,physical interaction ComPPI,IntAct
VEGFA U2AF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DHX9 U2AF1 25348397 N/A physical interaction ComPPI
SF3B1 U2AF1 25348397 N/A physical interaction ComPPI
SFPQ U2AF1 25348397 N/A physical interaction ComPPI
U2AF2 U2AF1 11551507 1388271 14525934 16189514 21460037 21516116 21988832 22365833 22939629 24234451 25348397 25416956 26344197 27898060 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,genetic,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
GSK3B U2AF1 25348397 N/A physical interaction ComPPI
CUL3 U2AF1 25348397 N/A physical interaction ComPPI
TUBA1B U2AF1 25348397 N/A physical interaction ComPPI
NTRK1 U2AF1 25348397 N/A physical interaction ComPPI
PRPF40A U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSAP U2AF1 25348397 N/A physical interaction ComPPI
HNRNPU U2AF1 25348397 N/A physical interaction ComPPI
CLK2 U2AF1 25348397 N/A physical interaction ComPPI
DDX5 U2AF1 25348397 N/A physical interaction ComPPI
PABPC1 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EWSR1 U2AF1 25348397 N/A physical interaction ComPPI
RBM10 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RCC1 U2AF1 25348397 N/A physical interaction ComPPI
SUV39H1 U2AF1 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RPS13 U2AF1 25348397 N/A physical interaction ComPPI
AP2B1 U2AF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SRSF1 U2AF1 14525934 18559666 21988832 24234451 25348397 8261509 9799243 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,two hybrid array ComPPI,HPRD,IntAct
SRSF2 U2AF1 14525934 18559666 22365833 24234451 25348397 8261509 physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction ComPPI,HPRD,IntAct
SCAF11 U2AF1 25348397 N/A physical interaction ComPPI
ZRANB2 U2AF1 11448987 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SRPK1 U2AF1 14525934 22365833 23602568 24234451 25348397 9472028 association,physical association two hybrid,experimental interaction detection,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
SON U2AF1 25348397 N/A physical interaction ComPPI
CUL1 U2AF1 25348397 N/A physical interaction ComPPI
SYNCRIP U2AF1 25348397 N/A physical interaction ComPPI
SEPTIN2 U2AF1 25348397 N/A physical interaction ComPPI
RNF2 U2AF1 25348397 N/A physical interaction ComPPI
SF3A1 U2AF1 25348397 N/A physical interaction ComPPI
NDN U2AF1 25348397 N/A physical interaction ComPPI
NCSTN U2AF1 25348397 N/A physical interaction ComPPI
GABARAP U2AF1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RP9 U2AF1 14525934 15474994 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
SF1 U2AF1 24234451 25348397 26420826 association anti bait coimmunoprecipitation ComPPI,IntAct
PSIP1 U2AF1 25348397 N/A physical interaction ComPPI
CUL7 U2AF1 25348397 N/A physical interaction ComPPI
CAND1 U2AF1 25348397 N/A physical interaction ComPPI
PRPF6 U2AF1 25348397 N/A physical interaction ComPPI
SRSF3 U2AF1 18559666 24234451 25348397 physical association fluorescent resonance energy transfer ComPPI,IntAct
BARD1 U2AF1 25348397 N/A physical interaction ComPPI
SMURF1 U2AF1 25348397 N/A physical interaction ComPPI
SNRPD2 U2AF1 25348397 N/A physical interaction ComPPI
ACIN1 U2AF1 25348397 N/A physical interaction ComPPI
NOP56 U2AF1 25348397 N/A physical interaction ComPPI
SRPK2 U2AF1 22365833 23602568 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,tandem affinity purification,bimolecular fluorescence complementation,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRPF4 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CIR1 U2AF1 15652350 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
SRSF5 U2AF1 25348397 N/A physical interaction ComPPI
TERF1 U2AF1 25348397 N/A physical interaction ComPPI
SNU13 U2AF1 25348397 N/A physical interaction ComPPI
SAFB U2AF1 25348397 N/A physical interaction ComPPI
SRSF7 U2AF1 25348397 N/A physical interaction ComPPI
SEPTIN7 U2AF1 25348397 N/A physical interaction ComPPI
SRRM2 U2AF1 25348397 N/A physical interaction ComPPI
RNPS1 U2AF1 17353931 22365833 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
HINFP U2AF1 25348397 N/A physical interaction ComPPI
HNRNPM U2AF1 25348397 N/A physical interaction ComPPI
LUC7L2 U2AF1 25348397 N/A physical interaction ComPPI
SF3B3 U2AF1 25348397 N/A physical interaction ComPPI
DHX38 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SRPK3 U2AF1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SUZ12 U2AF1 25348397 N/A physical interaction ComPPI
PRPF19 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SF3B6 U2AF1 25348397 N/A physical interaction ComPPI
SF3B2 U2AF1 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SARNP U2AF1 18559666 24234451 25348397 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer ComPPI,IntAct
DDX56 U2AF1 25348397 N/A physical interaction ComPPI
HDGF U2AF1 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
IK U2AF1 25348397 N/A physical interaction ComPPI
RPS2 U2AF1 25348397 N/A physical interaction ComPPI
RPS14 U2AF1 25348397 N/A physical interaction ComPPI
FTSJ3 U2AF1 25348397 N/A physical interaction ComPPI
DIDO1 U2AF1 25348397 N/A physical interaction ComPPI
ZCCHC10 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NKAP U2AF1 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
IL7R U2AF1 25348397 N/A physical interaction ComPPI
FBL U2AF1 25348397 N/A physical interaction ComPPI
CFAP20 U2AF1 25348397 N/A physical interaction ComPPI
SART1 U2AF1 25348397 N/A physical interaction ComPPI
PHGDH U2AF1 25348397 N/A physical interaction ComPPI
TOE1 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS4X U2AF1 25348397 N/A physical interaction ComPPI
FRA10AC1 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRPF38A U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPL15 U2AF1 25348397 N/A physical interaction ComPPI
S100A9 U2AF1 25348397 N/A physical interaction ComPPI
PRPF8 U2AF1 25348397 N/A physical interaction ComPPI
DCAF1 U2AF1 25348397 N/A physical interaction ComPPI
ZCCHC8 U2AF1 25348397 N/A physical interaction ComPPI
FN1 U2AF1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
U2AF1 NXF1 11724776 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
U2AF1 MEPCE 25348397 N/A physical interaction ComPPI
U2AF1 NOP58 25348397 N/A physical interaction ComPPI
U2AF1 RPS24 25348397 N/A physical interaction ComPPI
U2AF1 THOC6 25348397 N/A physical interaction ComPPI
U2AF1 RBM25 25348397 N/A physical interaction ComPPI
U2AF1 CHERP 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
U2AF1 JMJD6 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
U2AF1 OBSL1 25348397 N/A physical interaction ComPPI
U2AF1 ZNF746 25348397 N/A physical interaction ComPPI
U2AF1 U2AF1L4 25348397 N/A physical interaction ComPPI
U2AF1 CARNMT1 25348397 N/A physical interaction ComPPI
U2AF1 G3BP1 25348397 N/A physical interaction ComPPI
U2AF1 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
DDX41 U2AF1 24234451 25348397 25920683 association anti tag coimmunoprecipitation ComPPI,IntAct
NCL U2AF1 25348397 N/A physical interaction ComPPI
RRP7A U2AF1 25348397 N/A physical interaction ComPPI
ZRSR2 U2AF1 14525934 9237760 N/A experimental interaction detection,two hybrid HPRD
SF3A3 U2AF1 11533230 14525934 N/A experimental interaction detection HPRD
MAP1B U2AF1 14525934 16014633 N/A experimental interaction detection HPRD
L1TD1 U2AF1 24234451 25702638 association anti bait coimmunoprecipitation IntAct

Visualization










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