GENE：DCN
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DCN |
| FullNmae | decorin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2705 |
| EnsembleID | ENSG00000011465 |
| Uniprot | P07585 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DCN | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DCN | autophagy | 33034924 | The role of Dcn in stimulating autophagy was further supported by the fact that the observed effects were abrogated by knocking down autophagy-related protein 7 with Atg7 small interfering RNA. | retulator signature |
| DCN | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| DCN | apoptosis | 18518935 | DCN suppresses cell growth and induces apoptosis in various tumour cells. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DCN | GO:0003723,GO:0005515,GO:0005539,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005796,GO:0009887,GO:0010508,GO:0010596,GO:0016239,GO:0016239,GO:0016525,GO:0030021,GO:0030021,GO:0043202,GO:0045944,GO:0050840,GO:0051897,GO:0051901,GO:0062023,GO:0062023,GO:0090141,GO:1900747 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DCN | hsa:1634 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| DCN | hsa:1634 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DCN | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | DCN | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | DCN | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | DCN | 8798756 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR1H4 | DCN | 18514055 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DCN | MMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP2 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | TGFB1 | 25361965 | interaction type | N/A | PTMCode2 |
| TGFB1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL1A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL1A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | MMP7 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP7 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | THBS1 | 25361965 | interaction type | N/A | PTMCode2 |
| THBS1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL1A2 | 25361965 | interaction type | N/A | PTMCode2 |
| COL1A2 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL14A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL14A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | MMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP3 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | FBN1 | 25361965 | interaction type | N/A | PTMCode2 |
| FBN1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL4A5 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A5 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL6A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL6A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | DPT | 25361965 | interaction type | N/A | PTMCode2 |
| DPT | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL5A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL5A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | SFTPD | 25361965 | interaction type | N/A | PTMCode2 |
| SFTPD | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL4A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL4A3 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A3 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| DCN | COL4A4 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A4 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFB1 | DCN | 14525934 25348397 7638106 7798269 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| INS | DCN | 24234451 24389353 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI,IntAct |
| FLNA | DCN | 12106908 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| PLA2G2A | DCN | 10747008 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| PLAT | DCN | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | DCN | 24234451 25348397 25593058 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TNF | DCN | 12387878 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| C1QA | DCN | 1431141 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| SFTPD | DCN | 12730206 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| MET | DCN | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | DCN | 12105206 14525934 25348397 9988678 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| TGFB2 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| ZBTB33 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| INSR | DCN | 24234451 24389353 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI,IntAct |
| BMP1 | DCN | 25348397 | N/A | protease assay | ComPPI |
| BRCA1 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| FGF2 | DCN | 24234451 24447999 25348397 27898060 | N/A | solid phase assay | ComPPI,IntAct,OmniPath |
| IGF2 | DCN | 24234451 24389353 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI,IntAct |
| COL6A1 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| COL14A1 | DCN | 14525934 25348397 27898060 9252349 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| ELN | DCN | 11723132 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| AHSG | DCN | 12071714 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| KLHL17 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| DCN | FN1 | 14525934 1468447 1747115 24234451 25348397 | association | affinity chromatography technology,experimental interaction detection,solid phase assay | ComPPI,HPRD,IntAct |
| DCN | CHSY1 | 25348397 | N/A | physical interaction | ComPPI |
| DCN | LONP2 | 25348397 | N/A | physical interaction | ComPPI |
| DCN | FAM20B | 24234451 25331875 25348397 25789606 | phosphorylation reaction | protein kinase assay,phosphotransferase assay | ComPPI,IntAct |
| DCN | COL5A1 | 14525934 27898060 8440685 | N/A | experimental interaction detection | HPRD,OmniPath |
| DPT | DCN | 14525934 9895299 | N/A | experimental interaction detection | HPRD |
| DCN | COL4A3 | 10382266 14525934 | N/A | experimental interaction detection | HPRD |
| DCN | COL4A4 | 10382266 14525934 | N/A | experimental interaction detection | HPRD |
| DCN | COL1A1 | 14525934 1468447 9675033 | N/A | experimental interaction detection | HPRD |
| DCN | COL1A2 | 14525934 1468447 2375748 27898060 9675033 | N/A | experimental interaction detection | HPRD,OmniPath |
| MMP2 | DCN | 14525934 9148753 | N/A | experimental interaction detection | HPRD |
| MMP3 | DCN | 14525934 9148753 | N/A | experimental interaction detection | HPRD |
| MMP7 | DCN | 14525934 9148753 | N/A | experimental interaction detection | HPRD |
| THBS1 | DCN | 14525934 1550960 27898060 9328841 | N/A | experimental interaction detection | HPRD,OmniPath |
| COL4A5 | DCN | 10382266 14525934 | N/A | experimental interaction detection | HPRD |
| COL4A6 | DCN | 10382266 14525934 | N/A | experimental interaction detection | HPRD |
| CCN4 | DCN | 11598131 14525934 | N/A | experimental interaction detection | HPRD |
| DCN | UBC | 20665669 22279542 27898060 | N/A | N/A | OmniPath |
| DCN | FBN1 | 10793130 27898060 | N/A | N/A | OmniPath |
| DCN | TLR4 | 22087031 27898060 | N/A | N/A | OmniPath |
| DCN | TLR2 | 22087031 27898060 | N/A | N/A | OmniPath |
| DCN | ERBB4 | 10942781 27898060 | N/A | N/A | OmniPath |
| DCN | MET | 10942781 19433454 27898060 | N/A | N/A | OmniPath |