Gene Information gene info

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GENE：FGF23

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FGF23
FullNmae fibroblast growth factor 23
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3680
EnsembleID ENSG00000118972
Uniprot Q9GZV9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FGF23 autophagy 40096963 Furthermore, the relationship between FGF-regulated ferroptosis, Pyroptosis and Autophagy and AD is explored, along with the role of these mechanisms in improving the progression of AD. retulator signature

Go Annotation:

GeneSymbol Go id
FGF23 GO:0001934,GO:0005105,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0010628,GO:0010966,GO:0010980,GO:0030154,GO:0030334,GO:0030502,GO:0030643,GO:0032026,GO:0042369,GO:0044320,GO:0045668,GO:0045893,GO:0046888,GO:0055062,GO:0055074,GO:0070371,GO:0070374,GO:0071305,GO:0071354,GO:0071374,GO:0090080,GO:1904383

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FGF23 hsa:8074 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
FGF23 hsa:8074 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
FGF23 hsa:8074 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FGF23 hsa:8074 path:hsa05218 Melanoma - Homo sapiens (human)
FGF23 hsa:8074 path:hsa05224 Breast cancer - Homo sapiens (human)
FGF23 hsa:8074 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 FGF23 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 FGF23 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FGF23 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FGF23 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FGF23 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FGF23 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FGF23 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 FGF23 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 FGF23 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000006B702 FGF23 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001919B0 FGF23 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00000AD02D FGF23 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000012930C FGF23 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FGF23 FGFR1 25361965 interaction type N/A PTMCode2
FGFR1 FGF23 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FGFR2 FGF23 24234451 25241761 25348397 physical association physical interaction,in vitro,proximity ligation assay ComPPI,IntAct
FGFR3 FGF23 12032146 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FGFR1 FGF23 19966287 24234451 25348397 physical association molecular sieving,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
FGF23 PHEX 11409890 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FAM20C FGF23 24706917 25195776 27898060 N/A N/A OmniPath

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