GENE：LGALS9
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LGALS9 |
| FullNmae | galectin 9 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6570 |
| EnsembleID | ENSG00000168961 |
| Uniprot | O00182 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LGALS9 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| LGALS9 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| LGALS9 | autophagy | 38183492 | LGALS9 inhibits USP9X, activates PRKAA2, MAP3K7, ubiquitination, and autophagy. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LGALS9 | GO:0002519,GO:0005534,GO:0005615,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006935,GO:0006954,GO:0007565,GO:0010628,GO:0010628,GO:0010629,GO:0010629,GO:0016936,GO:0019899,GO:0030246,GO:0030246,GO:0032496,GO:0032682,GO:0032689,GO:0032689,GO:0032720,GO:0032729,GO:0032731,GO:0032733,GO:0032735,GO:0032736,GO:0032753,GO:0032753,GO:0032755,GO:0032757,GO:0032760,GO:0032834,GO:0038066,GO:0043123,GO:0043305,GO:0045953,GO:0046007,GO:0046598,GO:0048030,GO:0051092,GO:0060135,GO:0062023,GO:0070241,GO:0070371,GO:0070374,GO:0070555,GO:0071346,GO:0071636,GO:0071639,GO:0098586,GO:1901224,GO:2000510,GO:2000562,GO:2000562,GO:2000563,GO:2000670,GO:2001190,GO:2001200,GO:2001269 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LGALS9 | BAG6 | 16286920 22505239 26192618 27192565 | interaction type | N/A | ACSN |
| LGALS9 | HAVCR2 | 16286920 22505239 23180781 23967307 26192618 27192565 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| LGALS9 | FYN | 16286920 22505239 26192618 27192565 | interaction type | N/A | ACSN |
| APOB | LGALS9 | 18263896 23180781 | physical association | pull down | InnateDB |
| LGALS9 | FN1 | 18263896 23180781 | physical association | pull down | InnateDB |
| A2M | LGALS9 | 18263896 23180781 | physical association | pull down | InnateDB |
| LGALS9 | ITIH4 | 18263896 23180781 | physical association | pull down | InnateDB |
| LGALS9 | SERPING1 | 18263896 23180781 | physical association | pull down | InnateDB |
| LGALS9 | APOE | 18263896 23180781 | physical association | pull down | InnateDB |
| LGALS9 | CD44 | 20206131 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| LGALS9 | ITGA4 | 18024965 23180781 | physical association | pull down | InnateDB |
| LGALS9 | ITGA5 | 18024965 23180781 | physical association | pull down | InnateDB |
| ITGAL | LGALS9 | 18024965 23180781 | physical association | pull down | InnateDB |
| LGALS9 | ITGB1 | 18024965 23180781 | physical association | pull down | InnateDB |
| LGALS3 | LGALS9 | 17223646 23180781 | physical association | surface plasmon resonance | InnateDB |
| LGALS9 | LGALS8 | 17223646 23180781 | physical association | surface plasmon resonance | InnateDB |
| LGALS9 | LGALS9 | 17223646 23180781 | physical association | surface plasmon resonance | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | LGALS9 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | LGALS9 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | LGALS9 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | LGALS9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LGALS9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | LGALS9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | LGALS9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC3 | LGALS9 | 22027828 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | LGALS9 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000096022 | LGALS9 | 25416803 26239725 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LGALS3 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9C | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN11 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC9A3R2 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| JUP | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PDIA3 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PDIA6 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| P4HB | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LRP1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| MPZL1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CD47 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| MAN2B1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LNPEP | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| MET | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PLXNA1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CTNNB1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LAMB1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA4 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| FBLN1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ATP2B4 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LAMA1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC9A6 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PBK | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ECE1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CLCN3 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LUM | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CSPG4 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PTGFRN | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| KIAA1549 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SORL1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC29A1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC4A7 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PODXL | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC12A9 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| OSTM1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| RRAGB | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| USP39 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| NID1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ALCAM | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LAMA4 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| TSPAN3 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| NID2 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CD58 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ATG9A | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| CD63 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ZER1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| SLC12A4 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| FN1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRK | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC1A5 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | RNF13 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | KIAA0319L | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC12A2 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | MFAP3 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | COLEC12 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | CD109 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | NCR3LG1 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | PTPRJ | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC12A6 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | ATP11C | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | NAGLU | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | MRC2 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC12A7 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | ENPP4 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | ATP13A3 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC38A9 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | IGSF3 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | C2CD5 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | LGALS9B | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | PCDH9 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SUSD5 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | ACP2 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | CD276 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | HAVCR2 | 23967307 27192565 27898060 | N/A | N/A | OmniPath |