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GENE：BNIP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BNIP3
FullNmae BCL2 interacting protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1084
EnsembleID ENSG00000176171
Uniprot Q12983

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BNIP3 mpt 20668412 We also investigated the role of the mitochondrial permeability transition pore (mPTP) in Bnip3-induced autophagy. retulator signature
BNIP3 ferroptosis 38390208 Eight core ferroptosis-related genes (ATF3, BNIP3, DDIT4, LPIN1, NOS2, NQO1, SLC2A1 and SLC2A6) were further selected in random forest model, which showed high diagnostic performance for PCOS. retulator signature
BNIP3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BNIP3 autophagy 19229244 BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and autophagy. retulator signature
BNIP3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BNIP3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BNIP3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BNIP3 GO:0000422,GO:0001666,GO:0005515,GO:0005634,GO:0005634,GO:0005635,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0005783,GO:0005783,GO:0009617,GO:0010508,GO:0010637,GO:0010659,GO:0010666,GO:0010917,GO:0014069,GO:0016239,GO:0021987,GO:0030425,GO:0031966,GO:0031966,GO:0035694,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043068,GO:0043068,GO:0043069,GO:0043243,GO:0043653,GO:0045837,GO:0046902,GO:0048102,GO:0048678,GO:0048709,GO:0050873,GO:0051020,GO:0051402,GO:0051561,GO:0051607,GO:0055093,GO:0070301,GO:0071260,GO:0071279,GO:0071456,GO:0071456,GO:0072593,GO:0090141,GO:0090200,GO:0090649,GO:0097345,GO:0097345,GO:0140507,GO:1902109,GO:1903599,GO:1903715,GO:1990144,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BNIP3 hsa:664 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
BNIP3 hsa:664 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
BNIP3 hsa:664 path:hsa04140 Autophagy - animal - Homo sapiens (human)
BNIP3 hsa:664 path:hsa05131 Shigellosis - Homo sapiens (human)
BNIP3 hsa:664 path:hsa05134 Legionellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RHEB BNIP3 17928295 23180781 physical association two hybrid InnateDB
TMEM11 BNIP3 16189514 23180781 physical association pull down InnateDB
BNIP3 BNIP3L 23180781 25416956 physical association two hybrid InnateDB
BNIP3 KTN1 23180781 25416956 physical association two hybrid InnateDB
BNIP3 TMEM11 23180781 25416956 physical association two hybrid InnateDB
BNIP3 CLEC7A 23180781 25416956 physical association two hybrid InnateDB
BNIP3 FATE1 23180781 25416956 physical association two hybrid InnateDB
BNIP3 LDLRAD1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 BNIP3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BNIP3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 BNIP3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A BNIP3 17513511 17848618 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BNIP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 BNIP3 20332243 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 BNIP3 20018759 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 BNIP3 18927107 20332243 22815788 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000170CF4 BNIP3 20018759 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001B341F BNIP3 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000330617 BNIP3 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000055128B BNIP3 23688833 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 BNIP3 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
BNIP3 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BNIP3 25361965 interaction type N/A PTMCode2
BCL2L1 BNIP3 25361965 interaction type N/A PTMCode2
BNIP3 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2 BNIP3 25361965 interaction type N/A PTMCode2
BNIP3 BCL2 25361965 interaction type N/A PTMCode2
CD47 BNIP3 25361965 interaction type N/A PTMCode2
BNIP3 CD47 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TMEM11 BNIP3 16189514 24234451 25348397 25416956 27107012 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
SMIM3 BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22A BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LMNA BNIP3 25348397 N/A physical interaction ComPPI
BIK BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP1LC3B BNIP3 25348397 N/A physical interaction ComPPI
MALL BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
JAGN1 BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FATE1 BNIP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2L1 BNIP3 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
RPRM BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TGM2 BNIP3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KTN1 BNIP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CD3E BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD47 BNIP3 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
RHEB BNIP3 25348397 N/A physical interaction ComPPI
CREB3 BNIP3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2 BNIP3 10381623 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
PLP2 BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKN BNIP3 25348397 N/A physical interaction ComPPI
EBP BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIVEP1 BNIP3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BNIP3 NCBP1 25348397 N/A two hybrid,physical interaction ComPPI
BNIP3 BNIP3L 10381623 16189514 19060904 21516116 24234451 25348397 25416956 27107012 physical association anti tag coimmunoprecipitation,beta galactosidase complementation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
BNIP3 HDAC1 25348397 N/A physical interaction ComPPI
BNIP3 CLN8 25348397 N/A physical interaction ComPPI
BNIP3 CLEC7A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BNIP3 LDLRAD1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BNIP3 OPA1 20436456 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct,OmniPath
BNIP3 TMEM30A 25348397 N/A physical interaction ComPPI
BNIP3 PPTC7 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 ENPEP 25348397 N/A physical interaction ComPPI
BNIP3 PPP4R3B 25348397 N/A physical interaction ComPPI
BNIP3 PINK1 25348397 N/A physical interaction ComPPI
BNIP3 EBAG9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 MS4A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 TM4SF18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 CMTM3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 BNIP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 SEC23A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 HPN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 AMIGO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 TMEM205 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 SLC31A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 ZDHHC15 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 CLDN9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 SLC6A17 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 GPR42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 SPACA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 TMEM106C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3 PRELID1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
BNIP3 BNIP3 10381623 16189514 24234451 25416956 27107012 physical association anti tag coimmunoprecipitation,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid IntAct
AGTR1 BNIP3 24234451 28298427 physical association ubiquitin reconstruction IntAct
GPR37 BNIP3 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR2B BNIP3 24234451 28298427 physical association ubiquitin reconstruction IntAct
BNIP3 BCL2L1 10625696 27898060 inhibition N/A OmniPath
BNIP3 BCL2 10381623 10625696 19136941 23504944 27898060 7954800 inhibition N/A OmniPath
ACAA2 BNIP3 19136941 27898060 inhibition N/A OmniPath
BNIP3 RHEB 17928295 19136941 27898060 inhibition N/A OmniPath
RHEB BNIP3 17928295 27898060 N/A N/A OmniPath
HIF1A BNIP3 11559532 19136941 27898060 stimulant N/A OmniPath

Visualization










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