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GENE：PLK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLK2
FullNmae polo like kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19699
EnsembleID ENSG00000145632
Uniprot Q9NYY3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLK2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK2 mitotic_cd 33155931 Pharmacological inhibitors of G2 checkpoint members or genetic suppression of PLK1, PLK2, ATR, ATM, CHK1, and CHK2 can trigger DNA-damage-stimulated mitotic catastrophe. retulator signature
PLK2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PLK2 GO:0000082,GO:0000082,GO:0000776,GO:0000785,GO:0000922,GO:0002862,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005813,GO:0005813,GO:0005814,GO:0005814,GO:0005829,GO:0006468,GO:0006977,GO:0007052,GO:0007052,GO:0007052,GO:0007265,GO:0007613,GO:0010508,GO:0016525,GO:0018105,GO:0030425,GO:0032486,GO:0043008,GO:0043066,GO:0043123,GO:0045732,GO:0046599,GO:0046599,GO:0048167,GO:0048167,GO:0060291,GO:0060292,GO:0071866,GO:0090050,GO:0106310,GO:2000773

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLK2 hsa:10769 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 PLK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PLK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 PLK2 18832181 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001D69F6 PLK2 18832181 18927107 24969300 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000122ED0 PLK2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000486E0B PLK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PLK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004407DC PLK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD PLK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 PLK2 25416803 26910911 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PLK2 CENPJ 22135298 phosphorylation N/A PhosphoSite
PLK2 TP73 22135298 phosphorylation N/A PhosphoSite
PLK2 YWHAE 22135298 phosphorylation N/A PhosphoSite
PLK2 NPM1 22135298 phosphorylation N/A PhosphoSite
PLK2 FBXW7 22135298 phosphorylation N/A PhosphoSite
PLK2 SNCB 22135298 phosphorylation N/A PhosphoSite
PLK2 PLK1 22135298 phosphorylation N/A PhosphoSite
PLK2 SNCA 22135298 phosphorylation N/A PhosphoSite
PLK2 CIB1 25361965 interaction type N/A PTMCode2
CIB1 PLK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LENG1 PLK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK2 PLK2 25348397 N/A physical interaction ComPPI
CTSZ PLK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF5B PLK2 25348397 N/A physical interaction ComPPI
PLK2 CIB1 10523297 12651910 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PLK2 MPP3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PLK2 NEDD4 25348397 N/A physical interaction ComPPI
PLK2 SNCA 25348397 N/A physical interaction ComPPI
PLK2 APP 25348397 N/A physical interaction ComPPI
PLK2 CENPU 25348397 N/A physical interaction ComPPI
PLK2 CASK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PLK2 CDC20B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PLK2 KLK7 25348397 N/A physical interaction ComPPI
PLK2 CTSV 25348397 N/A physical interaction ComPPI
PLK2 RNASE7 25348397 N/A physical interaction ComPPI
PLK2 POF1B 25348397 N/A physical interaction ComPPI
PLK2 SUGP1 25348397 N/A physical interaction ComPPI
PLK2 TAF8 25348397 N/A physical interaction ComPPI
PLK2 CCDC12 25348397 N/A physical interaction ComPPI
PLK2 RABL6 25348397 N/A physical interaction ComPPI
PLK2 ANKRD44 25348397 N/A physical interaction ComPPI
PLK2 ANKRD28 25348397 N/A physical interaction ComPPI
PLK2 SERPINA12 25348397 N/A physical interaction ComPPI
PLK2 SAR1B 25348397 N/A physical interaction ComPPI
PLK2 CPA4 25348397 N/A physical interaction ComPPI
PLK2 CSTF1 25348397 N/A physical interaction ComPPI
PLK2 SDR9C7 25348397 N/A physical interaction ComPPI
PLK2 SERPINA1 25348397 N/A physical interaction ComPPI
PLK2 SERPINB7 25348397 N/A physical interaction ComPPI
PLK2 UNK 25348397 N/A physical interaction ComPPI
PLK2 XPO1 25348397 N/A physical interaction ComPPI
PLK2 ITPR1 25348397 N/A physical interaction ComPPI
PLK2 FXR1 25348397 N/A physical interaction ComPPI
PLK2 THRAP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 MFN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 FGD6 25348397 N/A physical interaction ComPPI
PLK2 PCGF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 RTN4IP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 IRGQ 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 MYO18A 25348397 N/A physical interaction ComPPI
PLK2 C1ORF226 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK2 ALAD 25348397 N/A physical interaction ComPPI
PLK2 FBXW7 25348397 N/A physical interaction ComPPI
PLK2 PLK1 19706541 24234451 25348397 phosphorylation reaction phosphorylation reaction,protein kinase assay ComPPI,IntAct
PLK2 ELP1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PLK2 DLGAP4 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PLK2 CENPJ 20531387 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
DNTTIP1 PLK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A2 PLK2 25348397 N/A physical interaction ComPPI
PLK2 FBXW7 22399798 27898060 inhibition N/A OmniPath
TP53 PLK2 18431400 27898060 inhibition N/A OmniPath
PLK2 NPM1 15190079 27898060 stimulant N/A OmniPath
PLK2 SNCA 19004816 19889641 21849493 22988096 27898060 stimulant N/A OmniPath
PLK2 SNCB 19889641 21849493 27898060 stimulant N/A OmniPath
PLK2 CENPJ 20531387 27898060 stimulant N/A OmniPath

Visualization










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