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GENE：CDK5R1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDK5R1
FullNmae cyclin dependent kinase 5 regulatory subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1775
EnsembleID ENSG00000176749
Uniprot Q15078

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDK5R1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDK5R1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CDK5R1 GO:0000079,GO:0000226,GO:0000307,GO:0001764,GO:0002020,GO:0004672,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0007158,GO:0007213,GO:0007411,GO:0007411,GO:0007413,GO:0007420,GO:0007420,GO:0007420,GO:0009792,GO:0014069,GO:0016020,GO:0016241,GO:0016301,GO:0016533,GO:0018105,GO:0018107,GO:0019901,GO:0019901,GO:0021549,GO:0021722,GO:0021766,GO:0021819,GO:0030182,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0030426,GO:0031116,GO:0031175,GO:0031175,GO:0031594,GO:0032956,GO:0035235,GO:0035255,GO:0043005,GO:0043014,GO:0043025,GO:0043197,GO:0043204,GO:0043231,GO:0043292,GO:0043525,GO:0043539,GO:0043539,GO:0045296,GO:0045664,GO:0045892,GO:0046875,GO:0048013,GO:0048471,GO:0048487,GO:0048511,GO:0051015,GO:0061001,GO:0061575,GO:0061575,GO:0070315,GO:0090314,GO:0098693,GO:0098793

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDK5R1 hsa:8851 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CDK5R1 hsa:8851 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CDK5R1 hsa:8851 path:hsa05030 Cocaine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK5R1 EGR1 15289351 23180781 physical association electrophoretic mobility supershift assay InnateDB
CDK5R1 LMTK2 12832520 23331499 stimulation N/A SignaLink,SignaLink
AATK CDK5R1 14521924 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CDK5R1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CDK5R1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CDK5R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDK5R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDK5R1 15289351 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDK5R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN CDK5R1 22550165 trascriptional regulation,stimulation inferred by curator TFlink
MYC CDK5R1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CDK5R1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000052E1A6 CDK5R1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C CDK5R1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032BD73 CDK5R1 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK5 CDK5R1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SIK2 CDK5R1 22135298 phosphorylation N/A PhosphoSite
CAPN1 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CAPN1 25361965 interaction type N/A PTMCode2
CDK5R1 CDK5RAP2 25361965 interaction type N/A PTMCode2
CDK5RAP2 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CDK5RAP3 25361965 interaction type N/A PTMCode2
CDK5RAP3 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 AMPH 25361965 interaction type N/A PTMCode2
AMPH CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 SET 25361965 interaction type N/A PTMCode2
SET CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CDK5 25361965 interaction type N/A PTMCode2
CAPN2 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CAPN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDK6 CDK5R1 25348397 N/A physical interaction ComPPI
SET CDK5R1 11741927 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ODF1 CDK5R1 25348397 N/A physical interaction ComPPI
CDK5R1 KRT40 25348397 N/A two hybrid,physical interaction ComPPI
CDK5R1 CDK16 12084709 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDK5R1 ACTN1 12223541 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDK5R1 AMPH 11113134 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDK5R1 PAK1 25348397 N/A in vivo ComPPI
CDK5R1 NES 12832492 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDK5R1 TTBK1 14525934 25348397 7556643 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDK5R1 CDK5RAP1 10721722 10915792 11882646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDK5R1 CDK5RAP3 10721722 10915792 11882646 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDK5R1 LMTK2 12832520 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CDK5R1 CDK9 12037672 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CDK5R1 CAPN1 10830966 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDK5R1 CAPN2 10830966 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDK5R1 CTNNB1 10753743 11168528 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
CDK5R1 STXBP1 14525934 25348397 27898060 9933594 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CDK5R1 TSC22D4 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDK5R1 CDK5 11583627 12223541 14521924 14525934 15689152 20133653 21220307 23602568 24234451 25348397 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,ion exchange chromatography,protein kinase assay,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDK5R1 CHN1 14525934 15013773 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CDK5R1 CDK5RAP2 10721722 11882646 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
CDK5R1 CAMK2A 25348397 N/A physical interaction ComPPI
CDK5R1 HDAC1 25348397 N/A physical interaction ComPPI
CDK5R1 HSP90AA1 25348397 N/A physical interaction ComPPI
CDK5R1 HSP90AA2P 25348397 N/A physical interaction ComPPI
CDK5R1 NEDD4 25348397 N/A physical interaction ComPPI
CDK5R1 CDK2 25348397 N/A physical interaction ComPPI
CDK5R1 CDK3 25348397 N/A physical interaction ComPPI
CDK5R1 CDK4 25348397 N/A physical interaction ComPPI
CDK5R1 APP 25348397 N/A physical interaction ComPPI
CDK5R1 SIAH1 25348397 N/A physical interaction ComPPI
CDK5R1 MTUS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDK5R1 BLOC1S6 25348397 N/A physical interaction ComPPI
CDK5R1 KRTAP10-3 25348397 N/A physical interaction ComPPI
CDK5R1 NOTCH2NLA 25348397 N/A physical interaction ComPPI
CDK5R1 MAPT 25348397 N/A physical interaction ComPPI
CDK5R1 UBE2T 25348397 N/A physical interaction ComPPI
CDK5R1 TPM2 25348397 N/A physical interaction ComPPI
CDK5R1 DENR 25348397 N/A physical interaction ComPPI
CDK5R1 PLPBP 25348397 N/A physical interaction ComPPI
CDK5R1 HMGCS1 25348397 N/A physical interaction ComPPI
CDK5R1 MVB12A 25348397 N/A physical interaction ComPPI
CDK5R1 MMAB 25348397 N/A physical interaction ComPPI
CDK5R1 RSPRY1 25348397 N/A physical interaction ComPPI
CDK5R1 UBXN1 25348397 N/A physical interaction ComPPI
CDK5R1 UBC 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDK5R1 UBA52 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDK5R1 AATK 14521924 24234451 25348397 phosphorylation reaction two hybrid,protein kinase assay ComPPI,IntAct
UBB CDK5R1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RPS27A CDK5R1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDK5R1 CDK5R1 11389014 14525934 N/A experimental interaction detection HPRD
CDK5R1 SUDS3 15489224 27898060 N/A N/A OmniPath
CDK5 CDK5R1 11389014 11583627 12223541 15013773 15689152 17036052 17121855 17591690 17762160 18326489 20097924 20133653 21220307 22654103 23602568 26186194 27898060 inhibition N/A OmniPath
CDK5R1 CDK5 10903889 11389014 11583627 12223541 15013773 15689152 17036052 17591690 17762160 18326489 20133653 21220307 22654103 23602568 26186194 27898060 stimulant N/A OmniPath
CAPN3 CDK5R1 25969760 27898060 stimulant N/A OmniPath
CAPN1 CDK5R1 10830966 25969760 27898060 stimulant N/A OmniPath
CAPN2 CDK5R1 10830966 25969760 27898060 stimulant N/A OmniPath
PPP2CA CDK5R1 21482799 27898060 N/A N/A OmniPath
SIK2 CDK5R1 24561619 27898060 inhibition N/A OmniPath
AATK CDK5R1 14521924 27898060 stimulant N/A OmniPath
PPP2CB CDK5R1 21482799 27898060 N/A N/A OmniPath
CHN1 CDK5R1 15013773 27898060 stimulant N/A OmniPath
CDK5R1 LMTK2 12832520 27898060 inhibition N/A OmniPath
AAK1 CDK5R1 17121855 18326489 20033852 27898060 N/A N/A OmniPath

Visualization










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