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GENE：TOP2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TOP2A
FullNmae DNA topoisomerase II alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11989
EnsembleID ENSG00000131747
Uniprot P11388

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TOP2A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOP2A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOP2A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOP2A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TOP2A GO:0000228,GO:0000287,GO:0000712,GO:0000775,GO:0000793,GO:0000819,GO:0001673,GO:0002244,GO:0003677,GO:0003682,GO:0003723,GO:0003918,GO:0003918,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006265,GO:0006265,GO:0006266,GO:0006974,GO:0007059,GO:0007143,GO:0008094,GO:0008301,GO:0009330,GO:0030263,GO:0030263,GO:0032991,GO:0040016,GO:0042752,GO:0042803,GO:0043065,GO:0043130,GO:0045870,GO:0045944,GO:0046982,GO:0048511,GO:1905463,GO:1990904

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TOP2A hsa:7153 path:hsa01524 Platinum drug resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TOP2A TP63 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
TOP2A CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIN1 TOP2A 11940573 23180781 physical association pull down InnateDB
ISG15 TOP2A 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
YWHAE TOP2A 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ESR1 TOP2A 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TOP2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TOP2A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TOP2A 10597187 19151767 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 TOP2A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TOP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 TOP2A 12104051 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TOP2A 11313881 trascriptional regulation,stimulation inferred by curator TFlink
UHRF1 TOP2A 10646863 trascriptional regulation,stimulation inferred by curator TFlink
MYB TOP2A N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 TOP2A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 TOP2A 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D TOP2A 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00002971AB TOP2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019D79B TOP2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 TOP2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004DA9DB TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B TOP2A 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 TOP2A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK3 TOP2A 22135298 phosphorylation N/A PhosphoSite
CDK1 TOP2A 22135298 phosphorylation N/A PhosphoSite
CDC7 TOP2A 22135298 phosphorylation N/A PhosphoSite
GSK3B TOP2A 22135298 phosphorylation N/A PhosphoSite
MAPK1 TOP2A 22135298 phosphorylation N/A PhosphoSite
PLK1 TOP2A 22135298 phosphorylation N/A PhosphoSite
PLK3 TOP2A 22135298 phosphorylation N/A PhosphoSite
MYC TOP2A 25361965 interaction type N/A PTMCode2
TOP2A MYC 25361965 interaction type N/A PTMCode2
RANBP2 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A RANBP2 25361965 interaction type N/A PTMCode2
RPA1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A RPA1 25361965 interaction type N/A PTMCode2
DHX9 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A DHX9 25361965 interaction type N/A PTMCode2
PIN1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A PIN1 25361965 interaction type N/A PTMCode2
TOP2A CSNK2A1 25361965 interaction type N/A PTMCode2
SUMO1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A SUMO1 25361965 interaction type N/A PTMCode2
BRCA1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A BRCA1 25361965 interaction type N/A PTMCode2
YWHAE TOP2A 25361965 interaction type N/A PTMCode2
TOP2A YWHAE 25361965 interaction type N/A PTMCode2
TP53 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A TP53 25361965 interaction type N/A PTMCode2
XPO1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A XPO1 25361965 interaction type N/A PTMCode2
SETMAR TOP2A 25361965 interaction type N/A PTMCode2
TOP2A SETMAR 25361965 interaction type N/A PTMCode2
FASN TOP2A 25361965 interaction type N/A PTMCode2
TOP2A FASN 25361965 interaction type N/A PTMCode2
CDC5L TOP2A 25361965 interaction type N/A PTMCode2
TOP2A CDC5L 25361965 interaction type N/A PTMCode2
CTNNB1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A CTNNB1 25361965 interaction type N/A PTMCode2
TOP1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A TOP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 TOP2A 11940573 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
UBE2I TOP2A 25348397 N/A physical interaction ComPPI
CUL5 TOP2A 25348397 N/A physical interaction ComPPI
CDC5L TOP2A 25348397 N/A physical interaction ComPPI
DAXX TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDX21 TOP2A 15034300 24234451 25348397 physical association chromatography technology ComPPI,IntAct
ISG15 TOP2A 25348397 N/A physical interaction ComPPI
LMNA TOP2A 25348397 N/A physical interaction ComPPI
MCM5 TOP2A 25348397 N/A physical interaction ComPPI
BMI1 TOP2A 25348397 N/A physical interaction ComPPI
RING1 TOP2A 25348397 N/A physical interaction ComPPI
GLYR1 TOP2A 25348397 N/A physical interaction ComPPI
RAC1 TOP2A 25348397 N/A physical interaction ComPPI
SMURF2 TOP2A 25348397 N/A physical interaction ComPPI
MAPK1 TOP2A 25348397 N/A physical interaction ComPPI
RPL10 TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCA TOP2A 12569090 14525934 25348397 7499337 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FBXW7 TOP2A 25348397 N/A physical interaction ComPPI
PRKCD TOP2A 16611985 24234451 25348397 27898060 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct,OmniPath
PRKDC TOP2A 20085707 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
JUN TOP2A 14525934 24234451 25348397 25609649 27898060 8387155 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
RB1 TOP2A 10393912 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SUMO1 TOP2A 10862613 12832072 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
DHX9 TOP2A 12711669 14525934 15034300 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
COPS5 TOP2A 15126503 21254166 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GSK3B TOP2A 25348397 N/A physical interaction ComPPI
UBB TOP2A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
UBC TOP2A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RPS27A TOP2A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
UBA52 TOP2A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PARP1 TOP2A 20085707 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
XRCC5 TOP2A 20085707 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA4 TOP2A 23698369 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 TOP2A 25348397 N/A physical interaction ComPPI
PLK1 TOP2A 25348397 N/A physical interaction ComPPI
MYC TOP2A 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKCB TOP2A 12569090 14525934 25348397 7499337 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPU TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A1 TOP2A 11940573 14525934 25348397 8939955 9804834 N/A experimental interaction detection,physical interaction,protein kinase assay,in vivo ComPPI,HPRD
CFTR TOP2A 25348397 N/A physical interaction ComPPI
EIF6 TOP2A 25348397 N/A physical interaction ComPPI
VDAC1 TOP2A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRKCG TOP2A 12569090 14525934 25348397 7499337 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BLM TOP2A 25348397 N/A physical interaction ComPPI
XPO1 TOP2A 12821127 14525934 19955415 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RPA2 TOP2A 25348397 N/A physical interaction ComPPI
RPA3 TOP2A 25348397 N/A physical interaction ComPPI
RNF168 TOP2A 25348397 N/A physical interaction ComPPI
SUMO2 TOP2A 25348397 N/A physical interaction ComPPI
SRPK1 TOP2A 14525934 15034300 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CUL2 TOP2A 25348397 N/A physical interaction ComPPI
CSNK2A2 TOP2A 25348397 N/A physical interaction ComPPI
YY1 TOP2A 23531880 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAE TOP2A 10788521 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
VHL TOP2A 25348397 N/A physical interaction ComPPI
NR4A1 TOP2A 25348397 N/A physical interaction ComPPI
HDAC2 TOP2A 25348397 N/A physical interaction,in vivo ComPPI
THBS3 TOP2A 25348397 N/A physical interaction ComPPI
RNF2 TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTNNB1 TOP2A 16230076 17983804 24234451 25348397 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
PIAS4 TOP2A 25348397 N/A physical interaction ComPPI
VCAM1 TOP2A 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 TOP2A 25348397 N/A physical interaction ComPPI
ELOC TOP2A 25348397 N/A physical interaction ComPPI
CUL7 TOP2A 25348397 N/A physical interaction ComPPI
H3C1 TOP2A 25348397 N/A physical interaction ComPPI
UPF3B TOP2A 25348397 N/A physical interaction ComPPI
RANBP2 TOP2A 18394993 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXA1 TOP2A 25348397 N/A physical interaction ComPPI
AIRE TOP2A 20085707 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H3-3A TOP2A 25348397 N/A physical interaction ComPPI
TFG TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SSRP1 TOP2A 25348397 N/A physical interaction ComPPI
NOP56 TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H2AX TOP2A 20085707 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ESR1 TOP2A 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
CDT1 TOP2A 25348397 N/A physical interaction ComPPI
BRCA1 TOP2A 14525934 15965487 24234451 25184681 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
CKAP5 TOP2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFB TOP2A 10959840 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
TERF2 TOP2A 25348397 N/A physical interaction ComPPI
FOXP1 TOP2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
UHRF1 TOP2A 25348397 N/A physical interaction ComPPI
CDH19 TOP2A 25348397 N/A physical interaction ComPPI
ARID1A TOP2A 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CTCF TOP2A 25348397 N/A physical interaction ComPPI
CSNK2B TOP2A 25348397 N/A physical interaction ComPPI
TOP1 TOP2A 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TOP2A SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TOP2A TOP2B 14525934 22939629 25348397 27898060 8710863 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
TOP2A HDAC1 11136718 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TOP2A TP53 10666337 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TOP2A SETMAR 18790802 19458360 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TOP2A SMARCAD1 25348397 N/A physical interaction ComPPI
TOP2A FN1 25348397 N/A physical interaction ComPPI
TOP2A OBSL1 25348397 N/A physical interaction ComPPI
TOP2A CCDC8 25348397 N/A physical interaction ComPPI
TOP2A THBS4 25348397 N/A physical interaction ComPPI
TOP2A UNK 25348397 N/A physical interaction ComPPI
TOP2A PATL1 25348397 N/A physical interaction ComPPI
TOP2A NOP2 25348397 N/A physical interaction ComPPI
TOP2A IFI16 25348397 N/A physical interaction ComPPI
TOP2A SPICE1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TOP2A L3MBTL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP2A FOXD3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TOP2A KMT2E 25348397 N/A physical interaction ComPPI
TOP2A AHSA1 25348397 N/A physical interaction ComPPI
TOP2A ASB3 25348397 N/A physical interaction ComPPI
TOP2A HSD3B2 25348397 N/A physical interaction ComPPI
TOP2A FAM131B 25348397 N/A physical interaction ComPPI
TOP2A INTU 25348397 N/A physical interaction ComPPI
TOP2A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP2A DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP2A AGO2 19955415 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP2A FOXM1 15965487 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP2A TCF4 17983804 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RBM4B TOP2A 25348397 N/A physical interaction ComPPI
CDK1 TOP2A 12569090 14525934 7635160 N/A experimental interaction detection HPRD
METTL14 TOP2A 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SMARCB1 TOP2A 24234451 30108113 association proximity-dependent biotin identification IntAct
MAGT1 TOP2A 24234451 30021884 physical association cross-linking study IntAct
H2BC9 TOP2A 24234451 30021884 physical association cross-linking study IntAct
TOP2A DHX16 24234451 30021884 physical association cross-linking study IntAct
FBXL13 TOP2A 24234451 30021884 physical association cross-linking study IntAct
TOP2A RESF1 24234451 30021884 physical association cross-linking study IntAct
H3-4 TOP2A 24234451 30021884 physical association cross-linking study IntAct
L1TD1 TOP2A 24234451 25702638 association anti bait coimmunoprecipitation IntAct
PRKCA TOP2A 12569090 18691976 19007248 19691289 27898060 7499337 N/A N/A OmniPath
PRKCB TOP2A 12569090 18691976 19007248 19691289 27898060 7499337 stimulant N/A OmniPath
PLK1 TOP2A 18171681 19098900 27898060 stimulant N/A OmniPath
TOP2A PIN1 11940573 16713569 19377505 27898060 N/A N/A OmniPath
PLK3 TOP2A 17081983 18062778 18669648 27898060 stimulant N/A OmniPath
PRKCG TOP2A 12569090 18691976 19007248 19691289 27898060 7499337 stimulant N/A OmniPath
MAPK3 TOP2A 20797634 21254166 27898060 7635160 N/A N/A OmniPath
ABL1 TOP2A 27898060 7961967 9761967 N/A N/A OmniPath
CDK1 TOP2A 12569090 16565220 16964243 17287340 17924679 18452278 18669648 18691976 18767875 19007248 19413330 19415658 19651622 19664994 19664995 19691289 20058876 20068230 20068231 27898060 7635160 N/A N/A OmniPath
MAPK1 TOP2A 10207078 11699638 27898060 7635160 7961967 9761967 9804834 N/A N/A OmniPath
CSNK2A1 TOP2A 10942766 11940573 16565220 16964243 17287340 18171681 18452278 18669648 18691976 18767875 19007248 19098900 19651622 19664994 19664995 19691289 20058876 20068231 21254166 22113938 26344197 27898060 7499337 7635160 7961967 8939955 9804834 stimulant N/A OmniPath
UHRF1 TOP2A 10646863 12530060 25451918 27898060 stimulant N/A OmniPath
ISG15 TOP2A 16009940 27898060 N/A N/A OmniPath

Visualization










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