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GENE：FZD5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FZD5
FullNmae frizzled class receptor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4043
EnsembleID ENSG00000163251
Uniprot Q13467

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FZD5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FZD5 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FZD5 GO:0000139,GO:0000578,GO:0001525,GO:0001540,GO:0001540,GO:0002071,GO:0002726,GO:0004930,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0005923,GO:0007186,GO:0007416,GO:0008285,GO:0008289,GO:0008595,GO:0009986,GO:0017147,GO:0017147,GO:0017147,GO:0019901,GO:0030182,GO:0030424,GO:0030425,GO:0030669,GO:0031077,GO:0031625,GO:0031901,GO:0032729,GO:0032731,GO:0032760,GO:0033077,GO:0035567,GO:0042813,GO:0042813,GO:0042813,GO:0042813,GO:0043204,GO:0044877,GO:0045202,GO:0045944,GO:0045944,GO:0048471,GO:0048596,GO:0060061,GO:0060070,GO:0060070,GO:0060070,GO:0060561,GO:0060574,GO:0060670,GO:0060715,GO:0060716,GO:0060718,GO:0071219,GO:1901382,GO:1903146,GO:1903955,GO:2000810

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FZD5 hsa:7855 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
FZD5 hsa:7855 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
FZD5 hsa:7855 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
FZD5 hsa:7855 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
FZD5 hsa:7855 path:hsa04916 Melanogenesis - Homo sapiens (human)
FZD5 hsa:7855 path:hsa04934 Cushing syndrome - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05224 Breast cancer - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
FZD5 hsa:7855 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WNT5A FZD5 23331499 9054360 stimulation N/A SignaLink,SignaLink
WNT10B FZD5 11092808 23331499 stimulation N/A SignaLink
WNT7A FZD5 12857724 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 FZD5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FZD5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A FZD5 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 FZD5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 FZD5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FZD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 FZD5 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C770D FZD5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 FZD5 25416803 25422915 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS000017EA6A FZD5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 FZD5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 FZD5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 FZD5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 FZD5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 FZD5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 FZD5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002AB575 FZD5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C FZD5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 FZD5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 FZD5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 FZD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B FZD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 FZD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A3D FZD5 25416803 25605017 mrna cleavage,inhibition rna immunoprecipitation,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
FZD5 GOPC 25361965 interaction type N/A PTMCode2
GOPC FZD5 25361965 interaction type N/A PTMCode2
FZD5 ROR2 25361965 interaction type N/A PTMCode2
ROR2 FZD5 25361965 interaction type N/A PTMCode2
WNT5A FZD5 25361965 interaction type N/A PTMCode2
FZD5 WNT5A 25361965 interaction type N/A PTMCode2
WNT7A FZD5 25361965 interaction type N/A PTMCode2
FZD5 WNT7A 25361965 interaction type N/A PTMCode2
LRP6 FZD5 25361965 interaction type N/A PTMCode2
FZD5 LRP6 25361965 interaction type N/A PTMCode2
CTNNB1 FZD5 25361965 interaction type N/A PTMCode2
FZD5 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ROR2 FZD5 12839624 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBTD1 FZD5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FZD5 WNT5A 14525934 24234451 25241761 25348397 9054360 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
FZD5 GOPC 11520064 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FZD5 WNT7A 12857724 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FZD5 LRP6 12857724 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FZD5 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FZD5 GSK3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FZD5 RGS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FZD5 ABI3BP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FZD5 LZTFL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FZD5 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FZD5 RNF43 25348397 N/A physical interaction ComPPI
FZD5 DVL2 25348397 N/A physical interaction ComPPI
FZD5 GPR21 25348397 N/A physical interaction ComPPI
FZD5 LRRK2 22899650 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
FZD5 BAMBI 18838381 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FZD5 SCYL2 19643732 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
FZD5 SLC35B1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WNT2 FZD5 18302287 27898060 stimulant N/A OmniPath
WNT5A FZD5 24032637 25241761 27898060 9054360 stimulant N/A OmniPath
WNT3A FZD5 22753465 27898060 stimulant N/A OmniPath
BAMBI FZD5 18838381 2662247 27898060 stimulant N/A OmniPath
WNT10B FZD5 11092808 12055200 27898060 stimulant N/A OmniPath
WNT7A FZD5 12857724 24032637 27898060 stimulant N/A OmniPath
CTHRC1 FZD5 18606138 27898060 N/A N/A OmniPath

Visualization










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