Gene Information gene info

  1. Home

GENE：LEPR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LEPR
FullNmae leptin receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6554
EnsembleID ENSG00000116678
Uniprot P48357

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LEPR autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LEPR autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LEPR GO:0001525,GO:0001934,GO:0004888,GO:0004896,GO:0005515,GO:0005576,GO:0005977,GO:0006094,GO:0006112,GO:0006909,GO:0007166,GO:0007275,GO:0008203,GO:0009897,GO:0010507,GO:0014009,GO:0016323,GO:0019221,GO:0019953,GO:0019955,GO:0030217,GO:0033210,GO:0033210,GO:0038021,GO:0038021,GO:0042593,GO:0043235,GO:0043235,GO:0044321,GO:0045721,GO:0046850,GO:0051049,GO:0060259,GO:0097009,GO:0098868,GO:0120162,GO:0150104

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LEPR hsa:3953 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
LEPR hsa:3953 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
LEPR hsa:3953 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
LEPR hsa:3953 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
LEPR hsa:3953 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
LEPR hsa:3953 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LEPR STAT3 21166956 phosphorylation reaction,stimulation N/A SignaLink
LEPR JAK2 12657512 21166956 23331499 8608603 phosphorylation reaction,stimulation N/A SignaLink,SignaLink
LEP LEPR 23331499 9207021 stimulation N/A SignaLink
LEPR JAK1 16173077 23331499 stimulation N/A SignaLink
LEPR TYK2 17228025 23331499 stimulation N/A SignaLink
LEPR STAT4 10582086 23331499 stimulation N/A SignaLink
CISH LEPR 18708154 23331499 stimulation N/A SignaLink
SOCS2 LEPR 18708154 23331499 stimulation N/A SignaLink
SOCS3 LEPR 11018044 18708154 21239736 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR LEPR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 LEPR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LEPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 LEPR 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D LEPR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171525 LEPR 25416803 25840984 mrna cleavage,inhibition array technology,western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
STAT3 LEPR 25361965 interaction type N/A PTMCode2
LEPR STAT3 25361965 interaction type N/A PTMCode2
LEPR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 LEPR 25361965 interaction type N/A PTMCode2
LEPR STAT5A 25361965 interaction type N/A PTMCode2
STAT5A LEPR 25361965 interaction type N/A PTMCode2
LEPR APOD 25361965 interaction type N/A PTMCode2
APOD LEPR 25361965 interaction type N/A PTMCode2
LEPR SNX6 25361965 interaction type N/A PTMCode2
SNX6 LEPR 25361965 interaction type N/A PTMCode2
LEPR SNX2 25361965 interaction type N/A PTMCode2
SNX2 LEPR 25361965 interaction type N/A PTMCode2
LEPR JAK2 25361965 interaction type N/A PTMCode2
JAK2 LEPR 25361965 interaction type N/A PTMCode2
LEPR JAK3 25361965 interaction type N/A PTMCode2
JAK3 LEPR 25361965 interaction type N/A PTMCode2
LEPR CISH 25361965 interaction type N/A PTMCode2
CISH LEPR 25361965 interaction type N/A PTMCode2
DGKZ LEPR 25361965 interaction type N/A PTMCode2
LEPR DGKZ 25361965 interaction type N/A PTMCode2
SNX4 LEPR 25361965 interaction type N/A PTMCode2
LEPR SNX4 25361965 interaction type N/A PTMCode2
LEP LEPR 25361965 interaction type N/A PTMCode2
LEPR LEP 25361965 interaction type N/A PTMCode2
SOCS3 LEPR 25361965 interaction type N/A PTMCode2
LEPR SOCS3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 LEPR 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SOCS3 LEPR 11018044 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TAFA4 LEPR 25348397 N/A physical interaction ComPPI
PTPN11 LEPR 11018044 11342028 14525934 24234451 25348397 27898060 9600917 association anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
GRB2 LEPR 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CLU LEPR 25348397 N/A in vitro ComPPI
UBC LEPR 25348397 N/A anti tag coimmunoprecipitation ComPPI
DGKZ LEPR 11078732 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
CDCP1 LEPR 25348397 N/A physical interaction ComPPI
SNX1 LEPR 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SNX2 LEPR 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SNX6 LEPR 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
APOD LEPR 11344130 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
LEPR STAT3 14525934 25348397 8608603 N/A experimental interaction detection,in vivo ComPPI,HPRD
LEPR JAK2 11585385 14525934 24234451 25348397 8608603 association coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
LEPR LEP 14525934 22405007 24234451 25348397 8608603 N/A cross-linking study,experimental interaction detection,molecular sieving,physical interaction,in vivo ComPPI,HPRD,IntAct
LEPR JAK3 11585385 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
LEPR SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LEPR CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LEPR RNF41 25348397 N/A physical interaction ComPPI
LEPR XRN1 25348397 N/A physical interaction ComPPI
LEPR FBXO6 25348397 N/A physical interaction ComPPI
LEPR BTNL8 25348397 N/A physical interaction ComPPI
LEPR ATP6V0D1 25348397 N/A physical interaction ComPPI
LEPR SCGB1D1 25348397 N/A physical interaction ComPPI
LEPR NDN 25348397 N/A physical interaction ComPPI
LEPR LEPROT 18042720 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,physical interaction ComPPI,IntAct,OmniPath
LEPR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LEPR PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LEPR LEPR 14525934 15771593 16116438 24234451 physical association bioluminescence resonance energy transfer,experimental interaction detection,fluorescent resonance energy transfer HPRD,IntAct
SOCS3 LEPR 11018044 18708154 21239736 27898060 inhibition,stimulant N/A OmniPath
ATM LEPR 14625304 27898060 N/A N/A OmniPath
LEPR JAK1 16173077 27898060 stimulant N/A OmniPath
LEPR TYK2 17228025 27898060 stimulant N/A OmniPath
LEPR JAK2 12657512 17312100 27898060 8608603 stimulant N/A OmniPath
LEPR STAT4 10582086 27898060 stimulant N/A OmniPath
SOCS2 LEPR 18708154 27898060 inhibition,stimulant N/A OmniPath
LEP LEPR 22405007 27898060 8608603 9207021 9463481 9786864 stimulant N/A OmniPath
CISH LEPR 18708154 27898060 stimulant N/A OmniPath

Visualization










  Return