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GENE：NEDD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEDD4
FullNmae NEDD4 E3 ubiquitin protein ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7727
EnsembleID ENSG00000069869
Uniprot P46934

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEDD4 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
NEDD4 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NEDD4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NEDD4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NEDD4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NEDD4 GO:0000151,GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005938,GO:0006511,GO:0006511,GO:0006622,GO:0007041,GO:0007528,GO:0010766,GO:0016241,GO:0016327,GO:0016567,GO:0016567,GO:0019871,GO:0019871,GO:0019899,GO:0019904,GO:0030948,GO:0031175,GO:0031175,GO:0031623,GO:0031623,GO:0031698,GO:0032801,GO:0032801,GO:0032991,GO:0034644,GO:0034765,GO:0042391,GO:0042921,GO:0043130,GO:0043162,GO:0043197,GO:0044111,GO:0045087,GO:0045732,GO:0046755,GO:0046824,GO:0048471,GO:0048814,GO:0048814,GO:0050807,GO:0050815,GO:0050816,GO:0050847,GO:0051592,GO:0051897,GO:0061630,GO:0061630,GO:0061630,GO:0070062,GO:0070063,GO:0070064,GO:0070064,GO:0070534,GO:1901016,GO:2000650,GO:2000650

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NEDD4 hsa:4734 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
NEDD4 hsa:4734 path:hsa04144 Endocytosis - Homo sapiens (human)
NEDD4 hsa:4734 path:hsa04530 Tight junction - Homo sapiens (human)
NEDD4 hsa:4734 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NLRP1 NEDD4 11408476 17218260 17218261 17996703 18562292 19465923 19652529 22679284 26192618 interaction type N/A ACSN
NEDD4 PTEN 17218260 17218261 17996703 18498243 18562292 19345329 19652529 21071413 22679284 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
NEDD4 MLANA 15703212 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NEDD4 ITCH 15703212 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NEDD4 ERBB4 17463226 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NEDD4 CFTR 19617352 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEDD4 SLC9A1 20855896 23180781 physical association anti tag coimmunoprecipitation InnateDB
GRB10 NEDD4 12697834 23331499 stimulation N/A SignaLink,SignaLink
NEDD4 IGF1R 12697834 18988627 19165858 21071413 23331499 stimulation N/A SignaLink,SignaLink
NEDD4 N 15620649 23331499 stimulation N/A SignaLink,SignaLink
NEDD4 DX 15620649 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ARRB1 NEDD4 20005715 interaction type N/A PSP,SignaLink
ARRB2 NEDD4 20005715 interaction type N/A PSP,SignaLink
EPS15 NEDD4 20005715 interaction type N/A PSP
GRB10 NEDD4 20005715 interaction type N/A PSP
HGS NEDD4 20005715 interaction type N/A PSP
NEDD4 CBL 12907674 20542890 inhibition N/A SignaLink
HGS NEDD4 12230472 18988627 20005715 20675381 21071413 N/A N/A SignaLink
GRB10 NEDD4 20005715 N/A N/A SignaLink
EPS15 NEDD4 11919637 17013377 18988627 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NEDD4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NEDD4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NEDD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NEDD4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NEDD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SIRT2 NEDD4 23175188 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 NEDD4 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000324096 NEDD4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000272039 NEDD4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000025C956 NEDD4 17592038 25416803 mrna cleavage,inhibition array technology,western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NEDD4 SCNN1B 25361965 interaction type N/A PTMCode2
SCNN1B NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 EPS15 25361965 interaction type N/A PTMCode2
EPS15 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 PTEN 25361965 interaction type N/A PTMCode2
PTEN NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 ISG15 25361965 interaction type N/A PTMCode2
ISG15 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 SH3KBP1 25361965 interaction type N/A PTMCode2
SH3KBP1 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 GRB10 25361965 interaction type N/A PTMCode2
GRB10 NEDD4 25361965 interaction type N/A PTMCode2
UBE2E1 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 UBE2E1 25361965 interaction type N/A PTMCode2
CBLB NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 CBLB 25361965 interaction type N/A PTMCode2
HGS NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 HGS 25361965 interaction type N/A PTMCode2
UBE2L3 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 UBE2L3 25361965 interaction type N/A PTMCode2
IGF1R NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 IGF1R 25361965 interaction type N/A PTMCode2
LAPTM5 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 LAPTM5 25361965 interaction type N/A PTMCode2
SCAMP3 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 SCAMP3 25361965 interaction type N/A PTMCode2
AP1G2 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 AP1G2 25361965 interaction type N/A PTMCode2
NDFIP2 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 NDFIP2 25361965 interaction type N/A PTMCode2
UBA1 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 UBA1 25361965 interaction type N/A PTMCode2
N4BP2 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 N4BP2 25361965 interaction type N/A PTMCode2
WBP1 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 WBP1 25361965 interaction type N/A PTMCode2
SCNN1G NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 SCNN1G 25361965 interaction type N/A PTMCode2
CD2BP2 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 CD2BP2 25361965 interaction type N/A PTMCode2
NDFIP1 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 NDFIP1 25361965 interaction type N/A PTMCode2
NFE2 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 NFE2 25361965 interaction type N/A PTMCode2
GGA3 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 GGA3 25361965 interaction type N/A PTMCode2
ANXA13 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 ANXA13 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK NEDD4 25348397 N/A physical interaction ComPPI
NUDT21 NEDD4 25348397 N/A physical interaction ComPPI
CCNH NEDD4 25348397 N/A physical interaction ComPPI
CUL5 NEDD4 25348397 N/A physical interaction ComPPI
YES1 NEDD4 25348397 N/A physical interaction ComPPI
SPRY2 NEDD4 25348397 N/A physical interaction ComPPI
SPRY1 NEDD4 25348397 N/A physical interaction ComPPI
SH3KBP1 NEDD4 12218189 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TBC1D7 NEDD4 25348397 N/A physical interaction ComPPI
CD2BP2 NEDD4 15105431 16000308 24234451 25348397 N/A peptide array,protein array ComPPI,IntAct
ISG15 NEDD4 18305167 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SFTPC NEDD4 19366705 19423771 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IMPDH2 NEDD4 25348397 N/A physical interaction ComPPI
SKIL NEDD4 25348397 N/A physical interaction ComPPI
ARRDC3 NEDD4 20559325 23208550 23236378 24234451 24379409 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
SMARCC1 NEDD4 25348397 N/A physical interaction ComPPI
AMOT NEDD4 25348397 N/A physical interaction ComPPI
WBP2 NEDD4 11042109 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GABARAPL2 NEDD4 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SUSD6 NEDD4 25348397 N/A physical interaction ComPPI
SKP1 NEDD4 25348397 N/A physical interaction ComPPI
UBE2D1 NEDD4 25348397 N/A physical interaction ComPPI
DCUN1D1 NEDD4 25348397 N/A physical interaction ComPPI
MAP1LC3B NEDD4 20562859 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
RAC1 NEDD4 22467858 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDK5R1 NEDD4 25348397 N/A physical interaction ComPPI
PRRG2 NEDD4 11042109 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LAPTM5 NEDD4 15231748 17116753 19953087 21765395 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
CSNK1D NEDD4 25348397 N/A physical interaction ComPPI
AP1G2 NEDD4 18772139 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NHP2 NEDD4 25348397 N/A physical interaction ComPPI
RNF7 NEDD4 25348397 N/A physical interaction ComPPI
SMURF2 NEDD4 25348397 N/A nuclear magnetic resonance,physical interaction,physical interaction ComPPI
ERRFI1 NEDD4 25348397 N/A physical interaction ComPPI
SMAD1 NEDD4 15231748 21308777 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
SYK NEDD4 25348397 N/A physical interaction ComPPI
PTK2B NEDD4 25348397 N/A physical interaction ComPPI
CBLB NEDD4 12907674 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ERBB4 NEDD4 25348397 N/A physical interaction ComPPI
OCLN NEDD4 25348397 N/A physical interaction ComPPI
SMAD7 NEDD4 25348397 N/A physical interaction ComPPI
SRC NEDD4 25348397 N/A physical interaction ComPPI
GRB10 NEDD4 10446181 12697834 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
FLT1 NEDD4 25348397 N/A physical interaction ComPPI
CASP3 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JUN NEDD4 25348397 N/A physical interaction ComPPI
SMAD2 NEDD4 25348397 N/A physical interaction ComPPI
SMAD3 NEDD4 25348397 N/A physical interaction ComPPI
RPL18A NEDD4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SMAD5 NEDD4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FGFR2 NEDD4 25348397 N/A physical interaction ComPPI
SCN5A NEDD4 25348397 N/A physical interaction ComPPI
UBE2D2 NEDD4 14525934 25348397 9182527 9990509 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
UBE2L3 NEDD4 14525934 25348397 9990509 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PKN2 NEDD4 25348397 N/A physical interaction ComPPI
PAX7 NEDD4 25348397 N/A physical interaction ComPPI
RBX1 NEDD4 25348397 N/A physical interaction ComPPI
SLC9A1 NEDD4 25348397 N/A physical interaction ComPPI
PDGFRB NEDD4 25348397 N/A physical interaction ComPPI
FES NEDD4 25348397 N/A physical interaction ComPPI
IRS2 NEDD4 25348397 N/A physical interaction ComPPI
HGS NEDD4 12230472 14525934 24234451 25348397 ubiquitination reaction anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
UBB NEDD4 17719543 24234451 25348397 enzymatic reaction pull down,physical interaction,enzymatic study ComPPI,IntAct
UBC NEDD4 19343052 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RPS27A NEDD4 25348397 N/A pull down,physical interaction ComPPI
UBA52 NEDD4 25348397 N/A pull down,physical interaction ComPPI
NTRK1 NEDD4 25348397 N/A physical interaction ComPPI
BTRC NEDD4 25348397 N/A physical interaction ComPPI
RUVBL1 NEDD4 25348397 N/A physical interaction ComPPI
CASP1 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RPS3A NEDD4 25348397 N/A physical interaction ComPPI
DIAPH1 NEDD4 25348397 N/A physical interaction ComPPI
KCNQ1 NEDD4 25348397 N/A physical interaction ComPPI
KCNAB1 NEDD4 25348397 N/A physical interaction ComPPI
KCNAB2 NEDD4 25348397 N/A physical interaction ComPPI
GBA NEDD4 25348397 N/A physical interaction ComPPI
PLK1 NEDD4 25348397 N/A physical interaction ComPPI
CASP7 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP3K5 NEDD4 25348397 N/A physical interaction ComPPI
RPS6KA4 NEDD4 25348397 N/A physical interaction ComPPI
HNRNPU NEDD4 25348397 N/A physical interaction ComPPI
MAP2 NEDD4 25348397 N/A physical interaction ComPPI
PRKX NEDD4 25348397 N/A physical interaction ComPPI
HNRNPL NEDD4 25348397 N/A physical interaction ComPPI
RPS6KA3 NEDD4 25348397 N/A physical interaction ComPPI
SCNN1G NEDD4 10212229 10642508 11359767 14525934 24234451 25348397 9351815 association experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PPARG NEDD4 25348397 N/A physical interaction ComPPI
CAD NEDD4 25348397 N/A physical interaction ComPPI
CALCOCO1 NEDD4 25348397 N/A physical interaction ComPPI
CFTR NEDD4 19617352 25348397 25384981 27898060 N/A physical interaction ComPPI,OmniPath
TRPV6 NEDD4 20843805 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PDLIM7 NEDD4 25348397 N/A physical interaction ComPPI
GRIN2D NEDD4 25348397 N/A physical interaction ComPPI
AKT3 NEDD4 25348397 N/A physical interaction ComPPI
MARK4 NEDD4 25348397 N/A physical interaction ComPPI
SYT1 NEDD4 25348397 N/A physical interaction ComPPI
TP73 NEDD4 14525934 15678106 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAPGEF6 NEDD4 25348397 N/A physical interaction ComPPI
RAP2A NEDD4 25348397 N/A physical interaction ComPPI
TNIK NEDD4 25348397 N/A physical interaction ComPPI
EPRS1 NEDD4 25348397 N/A physical interaction ComPPI
BRCA2 NEDD4 25348397 N/A physical interaction ComPPI
RAD51AP1 NEDD4 25348397 N/A physical interaction ComPPI
THOC1 NEDD4 25348397 N/A physical interaction ComPPI
ARRB1 NEDD4 25348397 N/A physical interaction ComPPI
RPS6KB1 NEDD4 25348397 N/A physical interaction ComPPI
EPS15 NEDD4 11919637 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TOM1L2 NEDD4 25348397 N/A physical interaction ComPPI
DVL1 NEDD4 25348397 N/A physical interaction ComPPI
ARRB2 NEDD4 23208550 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM2 NEDD4 15001356 24413081 25348397 27898060 N/A physical interaction ComPPI,OmniPath
YY1 NEDD4 25348397 N/A physical interaction ComPPI
CUL1 NEDD4 25348397 N/A physical interaction ComPPI
ADRB2 NEDD4 14525934 18544533 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EGFR NEDD4 24234451 25348397 29455656 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
SCNN1A NEDD4 10212229 10642508 11244092 11359767 12167593 14525934 15123669 18687683 23665454 24234451 25348397 27898060 8665844 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SCNN1B NEDD4 10212229 10642508 11244092 11323714 11359767 12167593 12654927 14525934 15123669 17544362 19953087 20237237 21765395 24234451 25348397 27898060 8665844 9923703 association experimental interaction detection,fluorescence polarization spectroscopy,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
FGFR1 NEDD4 21765395 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,peptide array,pull down,physical interaction ComPPI,IntAct
FLT4 NEDD4 25348397 N/A physical interaction ComPPI
SIVA1 NEDD4 25348397 N/A physical interaction ComPPI
IL2RB NEDD4 25348397 N/A physical interaction ComPPI
IRS1 NEDD4 25348397 N/A physical interaction ComPPI
SCN8A NEDD4 25348397 N/A physical interaction ComPPI
MARK2 NEDD4 25348397 N/A physical interaction ComPPI
FKBP3 NEDD4 25348397 N/A physical interaction ComPPI
RAF1 NEDD4 25348397 N/A physical interaction ComPPI
WEE1 NEDD4 25348397 N/A physical interaction ComPPI
URI1 NEDD4 25348397 N/A physical interaction ComPPI
POLR2E NEDD4 25348397 N/A physical interaction ComPPI
MAP4K5 NEDD4 25348397 N/A physical interaction ComPPI
POLR2A NEDD4 10490634 16055720 17996703 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GABARAP NEDD4 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
GRK7 NEDD4 25348397 N/A physical interaction ComPPI
MAP1LC3A NEDD4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EPHA5 NEDD4 25348397 N/A physical interaction ComPPI
TSG101 NEDD4 25348397 N/A physical interaction ComPPI
PTEN NEDD4 19345329 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TAF1B NEDD4 25348397 N/A physical interaction ComPPI
STK4 NEDD4 25348397 N/A physical interaction ComPPI
TNK2 NEDD4 25348397 N/A physical interaction ComPPI
GGA3 NEDD4 25348397 N/A physical interaction ComPPI
CDK5 NEDD4 25348397 N/A physical interaction ComPPI
IL2RG NEDD4 25348397 N/A physical interaction ComPPI
GRIN2A NEDD4 25348397 N/A physical interaction ComPPI
FYN NEDD4 25348397 N/A physical interaction ComPPI
RANBP10 NEDD4 25348397 N/A physical interaction ComPPI
CLIC2 NEDD4 25348397 N/A physical interaction ComPPI
DDX3X NEDD4 25348397 N/A physical interaction ComPPI
PSMD4 NEDD4 19240029 22350919 25348397 26205498 27898060 N/A physical interaction ComPPI,OmniPath
HNRNPUL1 NEDD4 25348397 N/A physical interaction ComPPI
NEDD4 ANXA13 10871286 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NEDD4 UBE2E1 14525934 17013377 18287095 23603909 24831002 25348397 27898060 9990509 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
NEDD4 SGK1 11696533 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NEDD4 UBE2D3 14525934 21399620 24234451 25348397 9990509 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
NEDD4 DAZAP2 11342538 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NEDD4 PMEPA1 11042109 12907594 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NEDD4 WBP1 11042109 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NEDD4 RNF11 11042109 14525934 15231748 20676133 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NEDD4 N4BP3 11717310 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NEDD4 LITAF 11042109 14525934 16118794 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
NEDD4 N4BP2 11717310 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
NEDD4 NDFIP1 11042109 11748237 14525934 22417925 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NEDD4 SCAMP3 14525934 19158374 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NEDD4 CDC25C 10037602 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NEDD4 NDFIP2 12050153 12796489 14525934 15252135 17013377 19343052 19953087 20522958 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
NEDD4 TTYH3 25348397 N/A physical interaction ComPPI
NEDD4 TTYH2 18577513 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 SLC6A3 16885233 20051513 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 PDCD6IP 25348397 N/A physical interaction ComPPI
NEDD4 GABARAPL1 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NEDD4 MLANA 20491914 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
NEDD4 SMAD6 25348397 N/A physical interaction ComPPI
NEDD4 CPSF6 25348397 N/A physical interaction ComPPI
NEDD4 UBAP2L 25348397 N/A physical interaction ComPPI
NEDD4 GJA1 16931598 19835873 19907029 21936631 24236122 25348397 25748165 26841867 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 RAPGEF2 11598133 21765395 24234451 24340059 25348397 27898060 N/A pull down,physical interaction ComPPI,IntAct,OmniPath
NEDD4 GRIA1 21148011 21338354 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 SLC12A3 25348397 N/A physical interaction ComPPI
NEDD4 SLC38A3 25348397 N/A physical interaction ComPPI
NEDD4 SLC11A2 25348397 N/A physical interaction ComPPI
NEDD4 MTMR4 19125695 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 RASGEF1A 25348397 N/A physical interaction ComPPI
NEDD4 UBOX5 25348397 N/A physical interaction ComPPI
NEDD4 CAMK1D 25348397 N/A physical interaction ComPPI
NEDD4 ABL2 25348397 N/A physical interaction ComPPI
NEDD4 MAPKAPK3 25348397 N/A physical interaction ComPPI
NEDD4 RTF1 25348397 N/A physical interaction ComPPI
NEDD4 ANKRD13D 25348397 N/A physical interaction ComPPI
NEDD4 TRIM52 25348397 N/A physical interaction ComPPI
NEDD4 BAIAP2 25348397 N/A physical interaction ComPPI
NEDD4 CUEDC1 25348397 N/A physical interaction ComPPI
NEDD4 SAMSN1 25348397 N/A physical interaction ComPPI
NEDD4 LUC7L2 25348397 N/A physical interaction ComPPI
NEDD4 MAP3K3 25348397 N/A physical interaction ComPPI
NEDD4 ABL1 25348397 N/A physical interaction ComPPI
NEDD4 STK31 25348397 N/A physical interaction ComPPI
NEDD4 AKT1 19953087 23195959 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 ERMN 25348397 N/A physical interaction ComPPI
NEDD4 SGK2 25348397 N/A physical interaction ComPPI
NEDD4 MAP3K2 25348397 N/A physical interaction ComPPI
NEDD4 JHY 25348397 N/A physical interaction ComPPI
NEDD4 TOM1 25348397 N/A physical interaction ComPPI
NEDD4 SPANXN3 25348397 N/A physical interaction ComPPI
NEDD4 DDX54 25348397 N/A physical interaction ComPPI
NEDD4 SNCA 25348397 N/A physical interaction ComPPI
NEDD4 ERG 25348397 N/A physical interaction ComPPI
NEDD4 ARRDC1 25348397 N/A physical interaction ComPPI
NEDD4 TEAD2 25348397 N/A physical interaction ComPPI
NEDD4 AMPD2 25348397 N/A physical interaction ComPPI
NEDD4 BMPR1A 25348397 N/A physical interaction ComPPI
NEDD4 GFUS 25348397 N/A physical interaction ComPPI
NEDD4 FGF12 25348397 N/A physical interaction ComPPI
NEDD4 NSRP1 25348397 N/A physical interaction ComPPI
NEDD4 EBAG9 25348397 N/A physical interaction ComPPI
NEDD4 MRPL19 25348397 N/A physical interaction ComPPI
NEDD4 RASL11B 25348397 N/A physical interaction ComPPI
NEDD4 SAAL1 25348397 N/A physical interaction ComPPI
NEDD4 SHTN1 25348397 N/A physical interaction ComPPI
NEDD4 TCP11L1 25348397 N/A physical interaction ComPPI
NEDD4 TCEANC 25348397 N/A physical interaction ComPPI
NEDD4 PYM1 25348397 N/A physical interaction ComPPI
NEDD4 ASPSCR1 25348397 N/A physical interaction ComPPI
NEDD4 HMCES 25348397 N/A physical interaction ComPPI
NEDD4 FGF21 25348397 N/A physical interaction ComPPI
NEDD4 RBCK1 25348397 N/A physical interaction ComPPI
NEDD4 KIFC3 25348397 N/A physical interaction ComPPI
NEDD4 SP140L 25348397 N/A physical interaction ComPPI
NEDD4 PARP16 25348397 N/A physical interaction ComPPI
NEDD4 PRR16 25348397 N/A physical interaction ComPPI
NEDD4 RPAP3 25348397 N/A physical interaction ComPPI
NEDD4 SLC23A2 25348397 N/A physical interaction ComPPI
NEDD4 PRRG1 25348397 N/A physical interaction ComPPI
NEDD4 UBE2M 25348397 N/A physical interaction ComPPI
NEDD4 SRMS 25348397 N/A physical interaction ComPPI
NEDD4 CAMK4 25348397 N/A physical interaction ComPPI
NEDD4 TBK1 25348397 N/A physical interaction ComPPI
NEDD4 STK24 25348397 N/A physical interaction ComPPI
NEDD4 STK25 25348397 N/A physical interaction ComPPI
NEDD4 STK26 25348397 N/A physical interaction ComPPI
NEDD4 GRK4 25348397 N/A physical interaction ComPPI
NEDD4 CLK3 25348397 N/A physical interaction ComPPI
NEDD4 AURKC 25348397 N/A physical interaction ComPPI
NEDD4 DYRK4 25348397 N/A physical interaction ComPPI
NEDD4 PRKG2 25348397 N/A physical interaction ComPPI
NEDD4 CAMKK2 25348397 N/A physical interaction ComPPI
NEDD4 SULF1 25348397 N/A physical interaction ComPPI
NEDD4 RFT1 25348397 N/A physical interaction ComPPI
NEDD4 ANXA9 25348397 N/A physical interaction ComPPI
NEDD4 DVL1P1 25348397 N/A physical interaction ComPPI
NEDD4 KIF26B 25348397 N/A physical interaction ComPPI
NEDD4 LAPTM4A 25348397 N/A physical interaction ComPPI
NEDD4 LAPTM4B 22096579 25348397 25588945 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 RPSA 25348397 N/A physical interaction ComPPI
NEDD4 BECN1 25348397 N/A physical interaction ComPPI
NEDD4 LRRK1 25348397 N/A physical interaction ComPPI
NEDD4 DMD 25348397 N/A physical interaction ComPPI
NEDD4 MGRN1 25348397 N/A physical interaction ComPPI
NEDD4 FBXL15 21572392 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEDD4 POLR2B 25348397 N/A physical interaction ComPPI
NEDD4 POLR2C 25348397 N/A physical interaction ComPPI
NEDD4 POLR3A 25348397 N/A physical interaction ComPPI
NEDD4 ARID1A 25348397 N/A physical interaction ComPPI
NEDD4 THRAP3 25348397 N/A physical interaction ComPPI
NEDD4 DHX30 25348397 N/A physical interaction ComPPI
NEDD4 RPAP2 25348397 N/A physical interaction ComPPI
NEDD4 PRPF8 25348397 N/A physical interaction ComPPI
NEDD4 SRSF7 25348397 N/A physical interaction ComPPI
NEDD4 AMOTL1 25348397 N/A physical interaction ComPPI
NEDD4 MYZAP 25348397 N/A physical interaction ComPPI
NEDD4 POLR2M 25348397 N/A physical interaction ComPPI
NEDD4 FBXL18 25348397 N/A physical interaction ComPPI
NEDD4 ERBB3 25348397 N/A physical interaction ComPPI
NEDD4 GUCD1 25348397 N/A physical interaction ComPPI
NEDD4 YOD1 25348397 N/A physical interaction ComPPI
NEDD4 SMO 23106887 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 PTCH1 25348397 N/A physical interaction ComPPI
NEDD4 MYCN 25348397 N/A physical interaction ComPPI
NEDD4 LATS1 25348397 N/A physical interaction ComPPI
NEDD4 FAM189B 25348397 N/A physical interaction ComPPI
NEDD4 TMEM171 25348397 N/A physical interaction ComPPI
NEDD4 FAM189A2 25348397 N/A physical interaction ComPPI
NEDD4 TMEM255A 25348397 N/A physical interaction ComPPI
NEDD4 TMEM92 25348397 N/A physical interaction ComPPI
NEDD4 TMEM52B 25348397 N/A physical interaction ComPPI
NEDD4 LDLRAD4 25348397 N/A physical interaction ComPPI
NEDD4 ABCB1 25348397 N/A physical interaction ComPPI
NEDD4 SAV1 25348397 N/A physical interaction ComPPI
NEDD4 LATS2 25348397 N/A physical interaction ComPPI
NEDD4 GLIS3 25348397 N/A physical interaction ComPPI
NEDD4 HSF1 25348397 N/A physical interaction ComPPI
NEDD4 ABCG1 25348397 N/A physical interaction ComPPI
NEDD4 IFITM3 25348397 N/A physical interaction ComPPI
NEDD4 KMT5C 25348397 N/A physical interaction ComPPI
NEDD4 DDIT4 25348397 N/A physical interaction ComPPI
NEDD4 ILDR1 25348397 N/A physical interaction ComPPI
NEDD4 TNFRSF19 25348397 N/A physical interaction ComPPI
NEDD4 PRRG3 25348397 N/A physical interaction ComPPI
NEDD4 PIP5K1C 25348397 N/A physical interaction ComPPI
NEDD4 SLC22A6 25348397 N/A physical interaction ComPPI
NEDD4 SLC22A8 25348397 N/A physical interaction ComPPI
NEDD4 MAP1LC3C 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
NFE2 NEDD4 14525934 25348397 9305852 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SEPTIN9 NEDD4 25348397 N/A physical interaction ComPPI
PLK2 NEDD4 25348397 N/A physical interaction ComPPI
CPSF1 NEDD4 25348397 N/A physical interaction ComPPI
IGF1R NEDD4 12697834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TMEM51 NEDD4 25348397 N/A physical interaction ComPPI
TRIM44 NEDD4 25348397 N/A physical interaction ComPPI
AQP2 NEDD4 25348397 N/A physical interaction ComPPI
COMM NEDD4 16531238 24234451 25348397 physical association experimental interaction detection,fluorescence technology,nuclear magnetic resonance,physical interaction ComPPI,IntAct
PTC NEDD4 25348397 N/A physical interaction ComPPI
STY NEDD4 25348397 N/A physical interaction ComPPI
SU(DX) NEDD4 25348397 N/A physical interaction ComPPI
TEN-M NEDD4 24234451 25294943 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
N NEDD4 25348397 N/A physical interaction ComPPI
FRL NEDD4 25348397 N/A physical interaction ComPPI
DALLY NEDD4 24234451 25294943 25348397 association pull down ComPPI,IntAct
NEDD4 NEDD4 11717310 14525934 N/A experimental interaction detection HPRD
H1-0 NEDD4 24234451 30021884 physical association cross-linking study IntAct
HNRNPM NEDD4 24234451 30021884 physical association cross-linking study IntAct
NEDD4 HUNK 22745772 27898060 N/A N/A OmniPath
CASP1 NEDD4 27898060 9593687 N/A N/A OmniPath
NEDD4 SCNN1G 10212229 10642508 11244092 11359767 11805112 12167593 15123669 17013377 27898060 8665844 9351815 N/A N/A OmniPath
NEDD4 PTEN 17218260 18498243 19345329 21986318 24063548 24141722 25547115 27898060 inhibition,stimulant N/A OmniPath
NEDD4 POLR2L 17996703 27898060 inhibition N/A OmniPath
CASP7 NEDD4 27898060 9593687 N/A N/A OmniPath
CASP3 NEDD4 27898060 9593687 N/A N/A OmniPath
NEDD4 IGF1R 12697834 18632619 19165858 1916586 27898060 inhibition,stimulant N/A OmniPath
GRB10 NEDD4 10446181 12697834 20980250 27898060 stimulant N/A OmniPath
CASP6 NEDD4 27898060 9593687 N/A N/A OmniPath

Visualization










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