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GENE：NOD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOD1
FullNmae nucleotide binding oligomerization domain containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16390
EnsembleID ENSG00000106100
Uniprot Q9Y239

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOD1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOD1 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NOD1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOD1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NOD1 GO:0001653,GO:0002221,GO:0002606,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006915,GO:0006919,GO:0006952,GO:0006954,GO:0007165,GO:0007249,GO:0007254,GO:0008656,GO:0009595,GO:0016045,GO:0016323,GO:0016324,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0034976,GO:0035556,GO:0035556,GO:0038187,GO:0042742,GO:0042802,GO:0042802,GO:0042803,GO:0042834,GO:0042834,GO:0043065,GO:0043123,GO:0043130,GO:0043280,GO:0044877,GO:0045087,GO:0045335,GO:0046330,GO:0050700,GO:0050829,GO:0050830,GO:0051092,GO:0060907,GO:0070371,GO:0070374,GO:0070427,GO:0071225,GO:0098792,GO:1901224,GO:1904417

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NOD1 hsa:10392 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
NOD1 hsa:10392 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
NOD1 hsa:10392 path:hsa05131 Shigellosis - Homo sapiens (human)
NOD1 hsa:10392 path:hsa05132 Salmonella infection - Homo sapiens (human)
NOD1 hsa:10392 path:hsa05133 Pertussis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOD1 TRIP6 15657077 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 NOD1 18186648 23180781 physical association x-ray crystallography InnateDB
NOD1 ACAP1 17005562 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 COPS3 17337451 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD1 GPS1 17337451 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD1 COPS6 17337451 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 COPS5 17337451 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 COPS7A 17337451 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 COPS8 17337451 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 HSP90AA1 17420470 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 SUGT1 17420470 17435760 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 CARD6 12775719 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 NLRC4 15107016 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 RIPK2 19337385 19667203 23180781 24958724 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD1 XIAP 19667203 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD1 ATG16L1 19898471 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID NOD1 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
NOD1 CFLAR 20005715 interaction type N/A PSP
NOD1 RIPK2 20005715 interaction type N/A PSP
NOD1 CASP1 20005715 interaction type N/A PSP
NOD1 CASP8 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 NOD1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NOD1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC NOD1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NOD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 NOD1 14688115 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000277201 NOD1 25416803 27836539 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 NOD1 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
NUDCD3 NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
XIAP NOD1 19667203 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CASP9 NOD1 10329646 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
OLFM4 NOD1 20534456 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABRB1 NOD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBC NOD1 25348397 N/A physical interaction ComPPI
HSP90AA1 NOD1 16083881 24234451 25036637 25348397 physical association anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
CASP1 NOD1 10329646 12459189 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HSPA1A NOD1 16083881 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
HSPA1B NOD1 25348397 N/A anti tag coimmunoprecipitation ComPPI
CASP8 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTGES3 NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CACYBP NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SOX8 NOD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GPS1 NOD1 25348397 N/A physical interaction ComPPI
COPS6 NOD1 25348397 N/A physical interaction ComPPI
RIPK2 NOD1 10224040 10329646 12459189 14525934 17054981 24234451 25348397 29997244 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PSMD2 NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TRAF4 NOD1 25348397 N/A physical interaction ComPPI
MAGED1 NOD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP2 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDC37 NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CFLAR NOD1 25348397 N/A physical interaction ComPPI
CASP4 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NOD1 NLRP1 11113115 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NOD1 CARD6 12775719 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NOD1 NLRC4 25348397 N/A physical interaction ComPPI
NOD1 HSP90AA2P 25348397 N/A physical interaction ComPPI
NOD1 SUGT1 17420470 23935490 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD1 PSMA7 25348397 N/A physical interaction ComPPI
NOD1 RNF34 25012219 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NOD1 SHMT2 25348397 N/A physical interaction ComPPI
NOD1 MOV10 25348397 N/A physical interaction ComPPI
NOD1 ATG16L1 25348397 N/A physical interaction ComPPI
NOD1 NOD2 25348397 N/A physical interaction ComPPI
NOD1 IRGM 25348397 N/A physical interaction ComPPI
NOD1 FKBP5 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
FKBPL NOD1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NOD1 NOD1 10329646 10880512 14525934 18186648 24234451 N/A experimental interaction detection,molecular sieving,x-ray crystallography HPRD,IntAct
NOD2 NOD1 15107016 27898060 inhibition N/A OmniPath
ABL2 NOD1 21552281 27898060 N/A N/A OmniPath
NOD1 RIPK2 10224040 10329646 10880512 11463746 11894098 12459189 15107016 16517750 17054981 19337385 19667203 22470564 23300079 24958724 27898060 inhibition,stimulant N/A OmniPath
XIAP NOD1 19667203 27898060 N/A N/A OmniPath
COPS6 NOD1 17337451 27898060 N/A N/A OmniPath
NOD1 COPS6 17337451 27898060 N/A N/A OmniPath
NOD1 ATG16L1 19898471 23300079 27898060 stimulant N/A OmniPath
NOD1 MAPK14 16365441 27898060 stimulant N/A OmniPath
NOD1 NFKBIA 10195894 10329646 10880512 16493424 27898060 7739562 7796813 7862124 7878466 8657102 N/A N/A OmniPath
NLRC4 NOD1 11472070 15107016 27898060 inhibition N/A OmniPath
COPS5 NOD1 17337451 27898060 N/A N/A OmniPath
NOD1 MAPK8 11463746 17186025 17947236 17965022 27898060 stimulant N/A OmniPath
NOD1 IKBKB 10195894 10837071 15691841 27898060 N/A N/A OmniPath
CARD6 NOD1 12775719 27898060 N/A N/A OmniPath
NOD1 TRIP6 15657077 27898060 N/A N/A OmniPath
COPS3 NOD1 17337451 27898060 N/A N/A OmniPath
NOD1 SUGT1 17420470 17435760 27898060 N/A N/A OmniPath
SUGT1 NOD1 17420470 17435760 27898060 stimulant N/A OmniPath
NOD1 ACAP1 17005562 27898060 N/A N/A OmniPath
GPS1 NOD1 17337451 27898060 N/A N/A OmniPath
COPS7A NOD1 17337451 27898060 N/A N/A OmniPath
COPS8 NOD1 17337451 27898060 N/A N/A OmniPath
NOD1 DEFB104A 10512755 11207625 15489856 16513653 27898060 stimulant N/A OmniPath

Visualization










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