GENE:PTPN22
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PTPN22 |
FullNmae | protein tyrosine phosphatase non-receptor type 22 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:9652 |
EnsembleID | ENSG00000134242 |
Uniprot | Q9Y2R2 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PTPN22 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTPN22 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTPN22 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PTPN22 | GO:0002230,GO:0004725,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0005829,GO:0006470,GO:0006470,GO:0006629,GO:0006914,GO:0009898,GO:0010507,GO:0010628,GO:0010629,GO:0016791,GO:0017124,GO:0019900,GO:0030217,GO:0030217,GO:0031625,GO:0031663,GO:0032481,GO:0032496,GO:0032715,GO:0032717,GO:0032720,GO:0032720,GO:0032729,GO:0032817,GO:0034141,GO:0034141,GO:0034145,GO:0034145,GO:0034157,GO:0034165,GO:0035335,GO:0035644,GO:0043508,GO:0045088,GO:0048471,GO:0050852,GO:0050852,GO:0050855,GO:0050860,GO:0050868,GO:0050868,GO:0070374,GO:0070374,GO:0070433,GO:0070433,GO:0071225,GO:0071663,GO:1900227,GO:1901222,GO:1901222,GO:1902523,GO:1902523,GO:1903753,GO:1903753,GO:2000566 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GRB2 | PTPN22 | 20005715 | interaction type | N/A | PSP |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | PTPN22 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | PTPN22 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
HIF1A | PTPN22 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
TP73 | PTPN22 | 19558638 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
FOXP3 | PTPN22 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA2 | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | PTPN22 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PRKCD | PTPN22 | 22135298 | phosphorylation | N/A | PhosphoSite |
LCK | PTPN22 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN22 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
CSK | PTPN22 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN22 | CSK | 25361965 | interaction type | N/A | PTMCode2 |
GRB2 | PTPN22 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN22 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
LZTS2 | PTPN22 | 25348397 | N/A | physical interaction | ComPPI |
WAS | PTPN22 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
VCP | PTPN22 | 16461343 24234451 25348397 | association | pull down,physical interaction | ComPPI,IntAct |
EIF3E | PTPN22 | 25348397 | N/A | physical interaction | ComPPI |
ERBB2 | PTPN22 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
CBL | PTPN22 | 10068674 14525934 25348397 | N/A | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
VAV1 | PTPN22 | 14525934 16461343 24234451 25348397 | association | experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
LCK | PTPN22 | 14525934 16461343 19167335 21719704 24234451 25348397 | dephosphorylation reaction,association | experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo | ComPPI,HPRD,IntAct |
PRKCD | PTPN22 | 14525934 18056643 24234451 25348397 | N/A | experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo | ComPPI,HPRD,IntAct |
SKAP2 | PTPN22 | 21719704 24234451 25348397 | dephosphorylation reaction,physical association | anti tag coimmunoprecipitation,x-ray crystallography,phosphatase assay | ComPPI,IntAct |
GRB2 | PTPN22 | 11882361 14525934 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,phage display,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
ZAP70 | PTPN22 | 14525934 16461343 24234451 25348397 | dephosphorylation reaction,association | experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo | ComPPI,HPRD,IntAct |
PTPN22 | CSK | 14525934 25348397 9582365 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
PTPN22 | CD3E | 14525934 16461343 24234451 25348397 | association | experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
PTPN22 | CD247 | 14525934 16461343 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
PTPN22 | SPTA1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | ACTA1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | EGFR | 24234451 24658140 25348397 | physical association | ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
PTPN22 | SRPK2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | CLK1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | PSTPIP2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | TBC1D31 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | KIF7 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | CEP131 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | PIBF1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | KIAA0753 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | MIB1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | MED4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | SSX2IP | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | CCDC138 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | MAD2L1BP | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | NDUFB10 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | PRKAR2A | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | NDUFA9 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | CALR | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | SLC25A19 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | SDF4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | MAIP1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | SFXN4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | HSPB1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | RCN1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | ACAD8 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | GLUD1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | HAX1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | SCO2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | CDH2 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
PTPN22 | PDGFRB | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
PTPN22 | NTRK1 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
PTPN22 | PDPK1 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
PTPN22 | GHR | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
PTPN22 | PSTPIP1 | 24234451 25040622 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down | ComPPI,IntAct,OmniPath |
PTPN22 | TRAF3 | 23871208 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
AKR7A2 | PTPN22 | 25348397 | N/A | physical interaction | ComPPI |
RPS19BP1 | PTPN22 | 25348397 | N/A | physical interaction | ComPPI |
CALU | PTPN22 | 25348397 | N/A | physical interaction | ComPPI |
PTPN22 | PTPN22 | 18056643 24234451 | N/A | x-ray crystallography | IntAct |
VIM | PTPN22 | 24234451 30021884 | physical association | cross-linking study | IntAct |
PTPN22 | LCK | 16461343 19167335 21719704 27898060 | inhibition | N/A | OmniPath |
PRKCD | PTPN22 | 18056643 27898060 | inhibition | N/A | OmniPath |
PTPN22 | CBL | 10068674 27898060 | inhibition | N/A | OmniPath |
PTPN22 | ZAP70 | 16461343 27898060 | inhibition | N/A | OmniPath |
PTPN22 | CD247 | 16461343 27898060 | inhibition | N/A | OmniPath |