GENE：TFEB
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TFEB |
| FullNmae | transcription factor EB |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11753 |
| EnsembleID | ENSG00000112561 |
| Uniprot | P19484 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TFEB | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| TFEB | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| TFEB | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TFEB | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TFEB | GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000981,GO:0001892,GO:0002250,GO:0003700,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0006355,GO:0006357,GO:0006914,GO:0006959,GO:0007040,GO:0007040,GO:0009267,GO:0010508,GO:0010508,GO:0019899,GO:0032418,GO:0034198,GO:0045893,GO:0045944,GO:0046983,GO:0140367,GO:1990837 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TFEB | hsa:7942 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| TFEB | hsa:7942 | path:hsa04137 | Mitophagy - animal - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TFEB | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | TFEB | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | TFEB | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TFEB | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | TFEB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MTOR | TFEB | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TAF9 | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| YWHAG | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| YWHAB | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| MAPT | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| GPNMB | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| SRPK1 | TFEB | 23602568 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| YWHAE | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| HDAC5 | TFEB | 25348397 | N/A | physical interaction | ComPPI |
| TFE3 | TFEB | 14525934 24234451 25348397 26496610 9806910 | association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| TFEB | TFEC | 14525934 25348397 9806910 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| TFEB | ATP5PF | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | IFIT1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | STT3A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | MITF | 14525934 25348397 9806910 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| TFEB | PPM1G | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | BAG2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | LCOR | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | MCAT | 25348397 | N/A | physical interaction | ComPPI |
| TFEB | EML4 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | TBC1D14 | 25348397 | N/A | physical interaction | ComPPI |
| TFEB | AK6 | 25348397 | N/A | physical interaction | ComPPI |
| TFEB | TRIM16 | 25348397 | N/A | physical interaction | ComPPI |
| TFEB | PPP3CB | 24234451 25348397 25720963 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TFEB | MT-CO2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TFEB | MAP1LC3B | 21617040 27898060 | N/A | N/A | OmniPath |
| MAPK1 | TFEB | 21617040 27898060 | inhibition | N/A | OmniPath |
| TFEB | SQSTM1 | 21617040 27898060 | N/A | N/A | OmniPath |
| MTOR | TFEB | 22343943 22692423 27898060 | inhibition | N/A | OmniPath |
| TFEB | UVRAG | 21617040 27898060 | N/A | N/A | OmniPath |
| PPP3CB | TFEB | 26000950 27898060 | stimulant | N/A | OmniPath |