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GENE：XBP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XBP1
FullNmae X-box binding protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12801
EnsembleID ENSG00000100219
Uniprot P17861

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XBP1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XBP1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XBP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XBP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
XBP1 GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001525,GO:0001889,GO:0002639,GO:0002639,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0006357,GO:0006366,GO:0006511,GO:0006633,GO:0006914,GO:0006915,GO:0006955,GO:0006990,GO:0006990,GO:0007517,GO:0008284,GO:0008284,GO:0010832,GO:0015031,GO:0030335,GO:0030968,GO:0031670,GO:0032755,GO:0032869,GO:0035356,GO:0035470,GO:0036498,GO:0036500,GO:0036503,GO:0042149,GO:0042632,GO:0042802,GO:0043066,GO:0045348,GO:0045579,GO:0045582,GO:0045600,GO:0045766,GO:0045944,GO:0045944,GO:0045944,GO:0046982,GO:0048666,GO:0055089,GO:0055092,GO:0060612,GO:0071222,GO:0071230,GO:0071332,GO:0071333,GO:0071353,GO:0071375,GO:0090575,GO:1900100,GO:1900103,GO:1902236,GO:1903489,GO:1990418,GO:1990837,GO:2000347

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XBP1 hsa:7494 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
XBP1 hsa:7494 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05010 Alzheimer disease - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05012 Parkinson disease - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
XBP1 hsa:7494 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATF6 XBP1 17991856 18360008 23180781 23850759 24269637 26192618 26587781 interaction type,physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay ACSN,InnateDB

Source Target Pmid Interactiontype Methods Database
AR XBP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 XBP1 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 XBP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 XBP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 XBP1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 XBP1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 XBP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PAX5 XBP1 8627152 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 XBP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 XBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF6 XBP1 20003459 24269637 trascriptional regulation,stimulation inferred by curator TFlink
BACH2 XBP1 24821775 trascriptional regulation,stimulation inferred by curator TFlink
BCL6 XBP1 24821775 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB XBP1 19717648 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007340 XBP1 19530237 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000160683 XBP1 22359598 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000007340 XBP1 18927107 19530237 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000160683 XBP1 22359598 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000001A7A XBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD XBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 XBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 XBP1 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 XBP1 25416803 26572862 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 XBP1 25416803 28052011 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 XBP1 22135298 phosphorylation N/A PhosphoSite
MAPK1 XBP1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I XBP1 23470653 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PCBD2 XBP1 25348397 N/A physical interaction ComPPI
VIM XBP1 25348397 N/A fluorescence microscopy ComPPI
ZNF440 XBP1 25348397 N/A physical interaction ComPPI
MCM2 XBP1 25348397 N/A physical interaction ComPPI
CREBZF XBP1 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
HIF1A XBP1 24234451 24670641 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TRIP4 XBP1 25348397 N/A physical interaction ComPPI
KAT2B XBP1 25348397 N/A physical interaction ComPPI
GLI1 XBP1 25348397 N/A physical interaction ComPPI
CANX XBP1 24234451 25239945 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
HSPA5 XBP1 24234451 25239945 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
RBL2 XBP1 25348397 N/A physical interaction ComPPI
PSMA6 XBP1 25348397 N/A pull down,physical interaction ComPPI
PSMA5 XBP1 25348397 N/A pull down,physical interaction ComPPI
NR0B2 XBP1 25348397 N/A physical interaction ComPPI
SRSF1 XBP1 25348397 N/A physical interaction ComPPI
KAT2A XBP1 25348397 N/A physical interaction ComPPI
RNF139 XBP1 25348397 N/A anti tag coimmunoprecipitation ComPPI
ATF6B XBP1 25348397 N/A physical interaction ComPPI
ATF6 XBP1 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
DERL1 XBP1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ESR1 XBP1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
CROCC XBP1 25348397 N/A physical interaction ComPPI
PSMA7 XBP1 25348397 N/A pull down ComPPI
UBE2V1 XBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HM13 XBP1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HDGF XBP1 25348397 N/A physical interaction ComPPI
SSX4 XBP1 25348397 N/A physical interaction ComPPI
ZNF580 XBP1 25348397 N/A physical interaction ComPPI
XBP1 FOS 1903538 25348397 27898060 N/A physical interaction ComPPI,OmniPath
XBP1 H1-0 25348397 N/A physical interaction ComPPI
XBP1 FUBP3 25348397 N/A physical interaction ComPPI
XBP1 H1-10 25348397 N/A physical interaction ComPPI
XBP1 PSMA8 25348397 N/A physical interaction ComPPI
XBP1 CCDC102B 25348397 N/A physical interaction ComPPI
XBP1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
XBP1 XBP1 12805554 20102225 24234451 N/A peptide array IntAct
ESR1 XBP1 12047351 12954762 14605097 27898060 stimulant N/A OmniPath
MAPK3 XBP1 23277279 27898060 N/A N/A OmniPath
ERN1 XBP1 18471544 27898060 stimulant N/A OmniPath
XBP1 BECN1 23184933 27898060 N/A N/A OmniPath

Visualization










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