GENE：FLCN
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FLCN |
| FullNmae | folliculin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:27310 |
| EnsembleID | ENSG00000154803 |
| Uniprot | Q8NFG4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FLCN | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| FLCN | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| FLCN | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FLCN | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| FLCN | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FLCN | GO:0000122,GO:0000122,GO:0001701,GO:0001932,GO:0001934,GO:0004857,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005813,GO:0005829,GO:0005829,GO:0005886,GO:0005929,GO:0005929,GO:0007043,GO:0007179,GO:0009267,GO:0010508,GO:0010508,GO:0010629,GO:0010823,GO:0019899,GO:0030097,GO:0030336,GO:0030496,GO:0030511,GO:0030511,GO:0031929,GO:0032006,GO:0032007,GO:0032008,GO:0032008,GO:0032418,GO:0032465,GO:0034198,GO:0035024,GO:0035065,GO:0043065,GO:0043491,GO:0044291,GO:0044877,GO:0045785,GO:0045820,GO:0045944,GO:0046578,GO:0050673,GO:0050680,GO:0051898,GO:0070371,GO:0070373,GO:0072111,GO:0072686,GO:0097009,GO:0097193,GO:0120163,GO:1900181,GO:1901723,GO:1901856,GO:1901859,GO:1901862,GO:1901874,GO:1903444,GO:1904263,GO:1904263,GO:1905672,GO:1990877,GO:2000973,GO:2001170,GO:2001244 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FLCN | hsa:201163 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| FLCN | hsa:201163 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | FLCN | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | FLCN | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FLCN | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | FLCN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003D5391 | FLCN | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000458AD2 | FLCN | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000057FDB8 | FLCN | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000016914 | FLCN | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | FLCN | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000061E50F | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001BCAC5 | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015F70F | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000081E1F | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000358C16 | FLCN | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000527B00 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FC26E | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | FLCN | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAA2 | FLCN | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FBP1 | FLCN | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| BAG3 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| MAP1LC3B | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| DPEP1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| RPL10 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| SF3B1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| STIP1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1A | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1B | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| PTGES3 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR3 | FLCN | 24234451 25348397 25561175 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CCT7 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| GABARAP | FLCN | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BANP | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| ALDOB | FLCN | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| CDC37 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| PPP5C | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| STUB1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| ULK1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG1 | FLCN | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| FBXW11 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| SF3B3 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| ZNF609 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| GABARAPL1 | FLCN | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| FAM120B | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| CCT4 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| CCT2 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| AHSA1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| CCT8 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| AGAP1 | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| APP | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA2P | FLCN | 25348397 | N/A | physical interaction | ComPPI |
| FNIP1 | FLCN | 17028174 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| FLCN | LDLRAD4 | 25348397 | N/A | physical interaction | ComPPI |
| FLCN | FNIP2 | 25348397 | N/A | physical interaction | ComPPI |
| FLCN | WDFY3 | 25348397 | N/A | physical interaction | ComPPI |
| FLCN | AGAP3 | 25348397 | N/A | physical interaction | ComPPI |
| FLCN | PGK2 | 25348397 | N/A | physical interaction | ComPPI |
| FLCN | TSTD2 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FLCN | HEMGN | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FLCN | CCDC180 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FLCN | NANS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FLCN | TMEFF1 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| HSPD1 | FLCN | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRKAA1 | FLCN | 19914239 27898060 | N/A | N/A | OmniPath |