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GENE：LRRK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRRK2
FullNmae leucine rich repeat kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18618
EnsembleID ENSG00000188906
Uniprot Q5S007

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRRK2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRRK2 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
LRRK2 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LRRK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRRK2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LRRK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRRK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LRRK2 GO:0000139,GO:0000149,GO:0000149,GO:0000165,GO:0000287,GO:0001933,GO:0001934,GO:0001934,GO:0003779,GO:0003924,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004706,GO:0004709,GO:0005096,GO:0005102,GO:0005515,GO:0005524,GO:0005525,GO:0005525,GO:0005615,GO:0005737,GO:0005737,GO:0005739,GO:0005741,GO:0005741,GO:0005743,GO:0005759,GO:0005764,GO:0005764,GO:0005768,GO:0005768,GO:0005783,GO:0005783,GO:0005789,GO:0005794,GO:0005794,GO:0005798,GO:0005802,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005902,GO:0006468,GO:0006468,GO:0006468,GO:0006606,GO:0006897,GO:0006897,GO:0006914,GO:0006979,GO:0007005,GO:0007005,GO:0007029,GO:0007029,GO:0007030,GO:0007030,GO:0007040,GO:0007254,GO:0007283,GO:0007528,GO:0008017,GO:0008104,GO:0008340,GO:0009267,GO:0010506,GO:0010508,GO:0010508,GO:0010508,GO:0010738,GO:0010955,GO:0010977,GO:0014041,GO:0015631,GO:0016242,GO:0016301,GO:0016301,GO:0016310,GO:0016323,GO:0017075,GO:0018105,GO:0018107,GO:0018107,GO:0019722,GO:0019722,GO:0021756,GO:0021772,GO:0022028,GO:0030159,GO:0030276,GO:0030424,GO:0030424,GO:0030424,GO:0030425,GO:0030425,GO:0030426,GO:0030672,GO:0031267,GO:0031398,GO:0031410,GO:0031647,GO:0031966,GO:0032088,GO:0032091,GO:0032092,GO:0032436,GO:0032473,GO:0032760,GO:0032839,GO:0034211,GO:0034211,GO:0034260,GO:0034599,GO:0034614,GO:0035556,GO:0035564,GO:0035640,GO:0035641,GO:0035751,GO:0036479,GO:0039706,GO:0040012,GO:0042391,GO:0042391,GO:0042802,GO:0042803,GO:0043005,GO:0043025,GO:0043068,GO:0043195,GO:0043204,GO:0043204,GO:0043204,GO:0043231,GO:0043406,GO:0043406,GO:0044325,GO:0044753,GO:0044754,GO:0045121,GO:0045860,GO:0046039,GO:0046777,GO:0046777,GO:0048312,GO:0048812,GO:0048812,GO:0051018,GO:0051018,GO:0051646,GO:0051770,GO:0051900,GO:0051966,GO:0060070,GO:0060079,GO:0060159,GO:0060159,GO:0060161,GO:0060628,GO:0060828,GO:0060828,GO:0061001,GO:0061001,GO:0070062,GO:0070585,GO:0070971,GO:0070971,GO:0070973,GO:0070973,GO:0071287,GO:0071356,GO:0071407,GO:0090140,GO:0090263,GO:0090394,GO:0097487,GO:0098794,GO:0098978,GO:0099400,GO:0099523,GO:0106310,GO:0140058,GO:1900244,GO:1902236,GO:1902499,GO:1902692,GO:1902803,GO:1902803,GO:1902803,GO:1902823,GO:1902902,GO:1902902,GO:1903125,GO:1903215,GO:1903217,GO:1903351,GO:1903980,GO:1904713,GO:1904887,GO:1904887,GO:1905279,GO:1905279,GO:1905289,GO:1990904,GO:1990909,GO:1990909,GO:2000172,GO:2000300,GO:2000377

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LRRK2 hsa:120892 path:hsa05012 Parkinson disease - Homo sapiens (human)
LRRK2 hsa:120892 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YBX1 LRRK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LRRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000016914 LRRK2 23125283 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000016914 LRRK2 23125283 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 LRRK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B0E50 LRRK2 23295946 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA LRRK2 22135298 phosphorylation N/A PhosphoSite
LRRK2 LRRK2 22135298 phosphorylation N/A PhosphoSite
LRRK2 RDX 22135298 phosphorylation N/A PhosphoSite
LRRK2 EZR 22135298 phosphorylation N/A PhosphoSite
LRRK2 TP53 22135298 phosphorylation N/A PhosphoSite
LRRK2 RPS11 22135298 phosphorylation N/A PhosphoSite
LRRK2 RAB5B 22135298 phosphorylation N/A PhosphoSite
LRRK2 AKT1 22135298 phosphorylation N/A PhosphoSite
LRRK2 NSF 22135298 phosphorylation N/A PhosphoSite
LRRK2 RPS15 22135298 phosphorylation N/A PhosphoSite
LRRK2 MSN 22135298 phosphorylation N/A PhosphoSite
LRRK2 SNAPIN 22135298 phosphorylation N/A PhosphoSite
CDK5 LRRK2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TBC1D22B LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
FAM90A1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
TCF25 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
ATP5PO LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HSPA8 LRRK2 17400507 23455607 24234451 24510904 24947832 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC42 LRRK2 21048939 21454543 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
RPL9 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPS7 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CD2BP2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
PPP1CC LRRK2 23937259 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
BAG3 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LDHB LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
LDHA LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NPM1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VIM LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PSMC6 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ACTG1 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R1A LRRK2 21983832 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP62 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TUBB LRRK2 18214993 19545277 24234451 24275654 24947832 25348397 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct,OmniPath
TK1 LRRK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EMD LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TP53BP1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CLNS1A LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LMNA LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RPL11 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CSNK1G2 LRRK2 24234451 25348397 25500533 phosphorylation reaction protein kinase assay ComPPI,IntAct
MRGBP LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
ACTB LRRK2 25348397 N/A physical interaction ComPPI
YWHAG LRRK2 20642453 23075850 24234451 24947832 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPP1CB LRRK2 23937259 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
CALM1 LRRK2 25348397 N/A physical interaction ComPPI
IQGAP3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPS15 LRRK2 24234451 24725412 24947832 25348397 26824392 phosphorylation reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,protein kinase assay,confocal microscopy ComPPI,IntAct
MRPL28 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SLC25A6 LRRK2 21370995 24234451 24725412 25348397 association,physical association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
RAC1 LRRK2 21454543 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
HSP90AB1 LRRK2 17400507 20642453 23075850 24234451 24947832 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUFM LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
FIS1 LRRK2 22639965 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
RACK1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RAB10 LRRK2 24234451 25348397 26824392 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,protein kinase assay ComPPI,IntAct
CSNK1D LRRK2 25348397 N/A protein kinase assay ComPPI
STAC LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
AP1G2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
STN1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RPL10A LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
PADI4 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
PAK1 LRRK2 21454543 24234451 25348397 physical association pull down ComPPI,IntAct
CBLB LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
PIK3R1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
MATK LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
FZD5 LRRK2 22899650 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
RAB8A LRRK2 24234451 25348397 26824392 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,protein kinase assay ComPPI,IntAct
PRKDC LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R8 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
HIF1A LRRK2 25348397 N/A physical interaction ComPPI
RBM39 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TPM2 LRRK2 25348397 N/A physical interaction ComPPI
RBBP6 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ZAP70 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RHOA LRRK2 21454543 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKACA LRRK2 24234451 24351927 24464040 25348397 phosphorylation reaction,association anti bait coimmunoprecipitation,protein kinase assay ComPPI,IntAct
PPP1R12A LRRK2 25348397 N/A physical interaction ComPPI
PSMD11 LRRK2 21983832 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2I LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
GSK3B LRRK2 24165324 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
KPNB1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
YWHAB LRRK2 20642453 24234451 24510904 24947832 25348397 association,physical association anti tag coimmunoprecipitation,protein array,pull down,physical interaction ComPPI,IntAct
YWHAZ LRRK2 20642453 23075850 24234451 24351927 24510904 24947832 25348397 association,physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,protein array,pull down,surface plasmon resonance,physical interaction ComPPI,IntAct
RAB7A LRRK2 25348397 N/A physical interaction ComPPI
TUBG1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TUBA1B LRRK2 24234451 24275654 25348397 association pull down ComPPI,IntAct
PFKP LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
UBB LRRK2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC LRRK2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A LRRK2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 LRRK2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HSP90AA1 LRRK2 16321986 17400507 18367605 19536328 19826009 20642453 20949042 22612223 23075850 24234451 24947832 25348397 26355680 27898060 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
ZMYM5 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
BAG1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
ITGB3BP LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RPS3A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
DIAPH1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CSNK1E LRRK2 24234451 25348397 25500533 phosphorylation reaction protein kinase assay ComPPI,IntAct
MAP2K4 LRRK2 25348397 N/A physical interaction ComPPI
DNM1 LRRK2 24234451 24282027 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct
WASF1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
STIP1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
PHB LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
APEX2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
POLE LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
PLK1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
CASP8 LRRK2 25348397 N/A physical interaction ComPPI
STRBP LRRK2 25348397 N/A physical interaction ComPPI
PPP1CA LRRK2 23937259 24234451 25348397 dephosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy,proximity ligation assay,protein phosphatase assay ComPPI,IntAct
MAPT LRRK2 22303461 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
PLEC LRRK2 25348397 N/A physical interaction ComPPI
RAB32 LRRK2 24234451 25348397 25360523 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,fluorescence microscopy ComPPI,IntAct,OmniPath
EEF1A1 LRRK2 25348397 N/A physical interaction ComPPI
CAPZA1 LRRK2 25348397 N/A physical interaction ComPPI
EIF4EBP1 LRRK2 18701920 20090955 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IQGAP1 LRRK2 21983832 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
TPR LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKCZ LRRK2 25348397 N/A physical interaction ComPPI
DDX5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RGS2 LRRK2 24234451 24794857 25348397 27898060 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,protein kinase assay,confocal microscopy ComPPI,IntAct,OmniPath
GNA13 LRRK2 25348397 N/A physical interaction ComPPI
MKI67 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC1 LRRK2 21370995 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
NFATC2 LRRK2 21983832 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SQSTM1 LRRK2 25348397 N/A physical interaction ComPPI
FADD LRRK2 19176810 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM3 LRRK2 25348397 N/A physical interaction ComPPI
PKM LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RAB1A LRRK2 24234451 25348397 26824392 phosphorylation reaction protein kinase assay ComPPI,IntAct
MAPK8IP2 LRRK2 20173330 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
CAMK2G LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RAB5A LRRK2 25348397 N/A physical interaction ComPPI
RAB5B LRRK2 18445495 24234451 25348397 25605758 27314038 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,protein kinase assay,confocal microscopy ComPPI,IntAct
EPRS1 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD51AP1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RANBP1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
H2AC18 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
YWHAQ LRRK2 20642453 20659021 21390248 22612223 23075850 24234451 24351927 24947832 25348397 27898060 association,physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,pull down,surface plasmon resonance,physical interaction ComPPI,IntAct,OmniPath
TMPO LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
E2F4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RBBP4 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RBBP8 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
TRAP1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
THOC1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TRAF2 LRRK2 25348397 N/A physical interaction ComPPI
CLTC LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCE1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SP100 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RPS18 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
RPL12 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PDCD4 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RPS13 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
RPLP0 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RIT1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
DVL1 LRRK2 25348397 N/A physical interaction ComPPI
ZRANB2 LRRK2 23075850 24234451 25348397 29513927 association anti tag coimmunoprecipitation,protein array ComPPI,IntAct
SRPK1 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL2 LRRK2 19625296 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
TNPO1 LRRK2 21983832 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNAPIN LRRK2 23949442 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay ComPPI,IntAct
SNX9 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CDK2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NAT1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TUBA1A LRRK2 24234451 24275654 24725412 25348397 association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
RAB11A LRRK2 25348397 N/A physical interaction ComPPI
YWHAH LRRK2 20642453 23075850 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SFN LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
YWHAE LRRK2 20642453 23075850 24234451 24725412 24947832 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
IRS1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
MBP LRRK2 16269541 17260967 17584768 17706965 19826009 21806997 25348397 27898060 N/A physical interaction ComPPI,OmniPath
LMNB1 LRRK2 23075850 24234451 25348397 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
CCT5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
POLD1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MAP2K6 LRRK2 20067578 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
HSPA4 LRRK2 25348397 N/A physical interaction ComPPI
TAF4 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VGLL4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
MMS19 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RAI14 LRRK2 25348397 N/A physical interaction ComPPI
HSPB1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ITCH LRRK2 25348397 N/A physical interaction ComPPI
NEK1 LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
MTA1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
TUBB4B LRRK2 24234451 24275654 25348397 physical association two hybrid ComPPI,IntAct
PTGS2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HSPA9 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK1 LRRK2 19176810 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK2 LRRK2 25348397 N/A physical interaction ComPPI
PSMD2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CSE1L LRRK2 21983832 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTR3 LRRK2 25348397 N/A physical interaction ComPPI
MSN LRRK2 20642453 22363216 22952686 23241358 24234451 24351927 24695735 24904275 25009464 25348397 26824392 27357661 phosphorylation reaction protein kinase assay ComPPI,IntAct
LGALS8 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
SH3GL3 LRRK2 25348397 N/A physical interaction ComPPI
DNM1L LRRK2 22228096 22639965 23813973 24234451 24282027 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
LAMP2 LRRK2 23455607 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
BCL2 LRRK2 25348397 N/A protein kinase assay ComPPI
ATP2A2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ATRX LRRK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PYGB LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SSR4 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RAB1B LRRK2 24234451 25348397 26824392 phosphorylation reaction protein kinase assay ComPPI,IntAct
ARHGEF7 LRRK2 21048939 24234451 25348397 25500533 phosphorylation reaction,colocalization,gtpase reaction,association,physical association anti tag coimmunoprecipitation,physical interaction,gtpase assay,protein kinase assay,confocal microscopy ComPPI,IntAct
DDX3X LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PRKN LRRK2 16352719 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
CXCL11 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
H3C1 LRRK2 25348397 N/A physical interaction ComPPI
IRAK1BP1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
TAF7L LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
NUP153 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SUPT4H1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RO60 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SH3GL2 LRRK2 22998870 24234451 25348397 25501810 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
WIPF1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
ARPC1B LRRK2 25348397 N/A physical interaction ComPPI
AP3B1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RANBP2 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CYFIP1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CYFIP2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PRPF6 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CDC37 LRRK2 16321986 18367605 20642453 22612223 23075850 24234451 25348397 association,physical association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PAK6 LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
ETV5 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LBR LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
BAX LRRK2 25348397 N/A physical interaction ComPPI
MAP2K7 LRRK2 20067578 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
DYNC1H1 LRRK2 25348397 N/A physical interaction ComPPI
H3-3A LRRK2 25348397 N/A physical interaction ComPPI
SNCA LRRK2 23183827 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
CENPF LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CALML5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CCL21 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
PDCL LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
MAP2K3 LRRK2 20067578 20173330 24234451 25348397 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2M1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HNRNPR LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TRADD LRRK2 19176810 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF3J LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF4B LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACIN1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STK3 LRRK2 25348397 N/A physical interaction ComPPI
STK24 LRRK2 25348397 N/A physical interaction ComPPI
NUP50 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DDIT4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
TUBB4A LRRK2 24234451 24275654 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
DDB1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
COPG2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ARFGAP1 LRRK2 22363216 24234451 25348397 29513927 colocalization protein array,physical interaction,confocal microscopy ComPPI,IntAct
HMMR LRRK2 25348397 N/A physical interaction ComPPI
RIF1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COPE LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NUP133 LRRK2 24234451 24725412 24947832 25348397 association protein array,tandem affinity purification ComPPI,IntAct
GAK LRRK2 24234451 24510904 24947832 25348397 29513927 colocalization,association,physical association anti tag coimmunoprecipitation,protein array,fluorescence microscopy,confocal microscopy ComPPI,IntAct
RAB11FIP2 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
DPYSL3 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
MCM3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPS6KB2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
DVL3 LRRK2 19625296 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
SUDS3 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
SAFB LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LATS1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
AKT1 LRRK2 21658387 24234451 25348397 phosphorylation reaction pull down,physical interaction,protein kinase assay ComPPI,IntAct
STUB1 LRRK2 24234451 24510904 25348397 29513927 N/A anti tag coimmunoprecipitation,protein array,physical interaction ComPPI,IntAct
VPS4A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PML LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CKAP5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SH3GL1 LRRK2 22998870 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
GNAI2 LRRK2 25348397 N/A physical interaction ComPPI
DYRK2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
NAP1L4 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DFFB LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
TAOK3 LRRK2 25348397 N/A physical interaction ComPPI
RPL23A LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
RPL13 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
RPL23 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MPRIP LRRK2 25348397 N/A physical interaction ComPPI
HACD3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MSH5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
EEF2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
EIF3L LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
DIS3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
KHSRP LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LIMS2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
DNAJA1 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RAB11B LRRK2 25348397 N/A physical interaction ComPPI
AFF4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
ESRRG LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SENP3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PSMD5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
AURKB LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SAFB2 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SCFD1 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1G LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CMAS LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRP6 LRRK2 22899650 24234451 25348397 27013965 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
RPS20 LRRK2 24234451 24725412 24947832 25348397 association protein array,tandem affinity purification ComPPI,IntAct
BAG2 LRRK2 24234451 24510904 25348397 29513927 N/A protein array ComPPI,IntAct
EFTUD2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NUP107 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TUBB1 LRRK2 24234451 24275654 25348397 physical association two hybrid ComPPI,IntAct
TTK LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
ACTR2 LRRK2 25348397 N/A physical interaction ComPPI
ARPC5 LRRK2 25348397 N/A physical interaction ComPPI
CSNK1G3 LRRK2 24234451 25348397 25500533 phosphorylation reaction protein kinase assay ComPPI,IntAct
PRDX3 LRRK2 21850687 24234451 24459295 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,protein kinase assay,confocal microscopy ComPPI,IntAct,OmniPath
EEF1D LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RGS1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
ACTR1B LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPL14 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
SF3B3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SPTLC1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CDC42EP3 LRRK2 24234451 24947832 25348397 29513927 N/A protein array ComPPI,IntAct
AGO2 LRRK2 17400507 20671708 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE3C LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
AGO1 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK1G1 LRRK2 24234451 25348397 25500533 phosphorylation reaction protein kinase assay ComPPI,IntAct
SCEL LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RAB29 LRRK2 24234451 24510904 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,protein array,fluorescence microscopy,confocal microscopy ComPPI,IntAct
UFD1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
H2BC3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NCLN LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ABL2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RUVBL2 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MYL12B LRRK2 25348397 N/A physical interaction ComPPI
TCP10L LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
DBF4B LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
SF3B2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
KLC2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
POLDIP3 LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CDC25A LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
AHDC1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
HSPD1 LRRK2 25348397 N/A physical interaction ComPPI
CAMK1D LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
ARPC2 LRRK2 25348397 N/A physical interaction ComPPI
ARPC4 LRRK2 25348397 N/A physical interaction ComPPI
EPS8L2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RPSA LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
USP39 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
WDR5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SMAP1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MYO1C LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTA2 LRRK2 25348397 N/A physical interaction ComPPI
ACTG2 LRRK2 25348397 N/A physical interaction ComPPI
ZFAND5 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
RPL24 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NUP160 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ECHS1 LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
DAPP1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
HNRNPH3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ACTA1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
EEF1A2 LRRK2 19559761 24234451 25348397 27898060 physical association protein kinase assay ComPPI,IntAct,OmniPath
RPS2 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
ATP5F1A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ACLY LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MAP1B LRRK2 25348397 N/A physical interaction ComPPI
MYL1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SLC25A5 LRRK2 21370995 24234451 24725412 25348397 association,physical association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
ADRM1 LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AURKC LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RPS14 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HK1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MYO1F LRRK2 25348397 N/A physical interaction ComPPI
RPS15A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RALYL LRRK2 25348397 N/A physical interaction ComPPI
GPBP1L1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
MYL6 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TUBB3 LRRK2 24234451 24275654 25348397 association,physical association two hybrid,pull down ComPPI,IntAct
CEP72 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
MLLT3 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
UQCRB LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
DIDO1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
STK25 LRRK2 25348397 N/A physical interaction ComPPI
CETN3 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
COQ8A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PTCD3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MSH2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CHGB LRRK2 24234451 24510904 24947832 25348397 29513927 N/A protein array ComPPI,IntAct
C18ORF25 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RPL30 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
POU5F1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
AKT2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RPS11 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
AIFM1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PSMD6 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CFAP20 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
NUMA1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LIMA1 LRRK2 25348397 N/A physical interaction ComPPI
RPAP3 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
TTC27 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SLC25A4 LRRK2 21370995 24234451 24725412 25348397 association,physical association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
CNP LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TUBA1C LRRK2 24234451 24275654 25348397 association pull down,physical interaction ComPPI,IntAct
SLC25A11 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
COX6C LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
DBN1 LRRK2 25348397 N/A physical interaction ComPPI
MAGED2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MYL9 LRRK2 24234451 24510904 25348397 N/A protein array,physical interaction ComPPI,IntAct
SPIN1 LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RPL21 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MPC2 LRRK2 25348397 N/A physical interaction ComPPI
RPL17 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
RPS3 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
RPS27 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
PRPSAP2 LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PTPN23 LRRK2 25348397 N/A physical interaction ComPPI
MOGS LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
STK40 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
AFG3L2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
MFN2 LRRK2 24234451 24282027 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
NEURL4 LRRK2 25348397 N/A physical interaction ComPPI
FAAP24 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
FANCM LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
ANKS4B LRRK2 24234451 24947832 25348397 29513927 N/A protein array ComPPI,IntAct
SEC16A LRRK2 24234451 25201882 25348397 27898060 colocalization,association,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct,OmniPath
ATP5MG LRRK2 25348397 N/A physical interaction ComPPI
MRPL19 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
RPL3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPS16 LRRK2 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
KIF2A LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LMNB2 LRRK2 23075850 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRIB2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
IGKC LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
AHCYL1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
YME1L1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TOR1AIP1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HERC2 LRRK2 25348397 N/A physical interaction ComPPI
HMGN2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CUEDC1 LRRK2 24234451 24510904 25348397 29513927 N/A protein array ComPPI,IntAct
AKAP8 LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A1P5 LRRK2 25348397 N/A physical interaction ComPPI
ABL1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
TP53 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CBX3 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DVL1P1 LRRK2 25348397 N/A physical interaction ComPPI
FAM27E3 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
FAM107A LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
MATR3 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TPM1 LRRK2 25348397 N/A physical interaction ComPPI
CCT3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
POLR2M LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
TCEA2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
NSL1 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
RBBP7 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HERC2P3 LRRK2 25348397 N/A physical interaction ComPPI
PPP4R3A LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK1 LRRK2 19712061 20144646 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
MYO1B LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RPS19 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
RPL34 LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MTHFD2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CAPZB LRRK2 25348397 N/A physical interaction ComPPI
LAS1L LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CAPZA2 LRRK2 25348397 N/A physical interaction ComPPI
MYO1D LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SLC25A22 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
OBI1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
QPCTL LRRK2 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SFXN1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SLC25A1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NCL LRRK2 23075850 24234451 24725412 25348397 association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
RPL36A LRRK2 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
HSP90AA2P LRRK2 25348397 N/A physical interaction ComPPI
GNA12 LRRK2 25348397 N/A physical interaction ComPPI
TUBB2A LRRK2 24234451 24275654 25348397 physical association two hybrid ComPPI,IntAct
ERG LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
WASF2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
CSNK1A1 LRRK2 24234451 25348397 25500533 association anti tag coimmunoprecipitation ComPPI,IntAct
IPO5 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
DPM3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TUBB2B LRRK2 24234451 24275654 25348397 physical association two hybrid ComPPI,IntAct
DAPK1 LRRK2 19712061 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NKRF LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CHERP LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CWC15 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
FARSA LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
BAG5 LRRK2 24234451 24510904 24947832 25348397 association,physical association anti tag coimmunoprecipitation,protein array,pull down,physical interaction ComPPI,IntAct
TMOD3 LRRK2 25348397 N/A physical interaction ComPPI
LRRC47 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LARP7 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
NTPCR LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HELLS LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
WSB1 LRRK2 24234451 25348397 27273569 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
FCHSD1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 RPS8 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
LRRK2 MDN1 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRRK2 ACTBL2 25348397 N/A physical interaction ComPPI
LRRK2 EFHD2 25348397 N/A physical interaction ComPPI
LRRK2 L3MBTL3 25348397 N/A physical interaction ComPPI
LRRK2 CHD1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRRK2 HROB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRRK2 OPA1 24234451 24282027 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
LRRK2 TUBB6 24234451 24275654 25348397 physical association two hybrid ComPPI,IntAct
LRRK2 DUX3 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 RBIS 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 XIRP2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 FAM47B 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 CCDC43 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 VASH2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 NDUFAF7 24234451 24510904 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 ENKUR 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
LRRK2 PGM3 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 PYCR1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 RPS23 24234451 24725412 25348397 phosphorylation reaction,association protein kinase assay,tandem affinity purification ComPPI,IntAct
LRRK2 IGHA1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 RPS4Y1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 SLFN5 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 DHX16 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 RPS5 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 RPL19 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 NDUFB4 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 NOMO2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 ACSL5 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 ALDH8A1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 LDHAL6A 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 SAMHD1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
LRRK2 RPL39 24234451 24725412 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
LRRK2 VGF 24234451 24947832 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LRRK2 TEX33 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 PSMG1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 ZSCAN26 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 EOGT 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 CPTP 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 MRNIP 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 SPATA24 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 HOGA1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 GIMAP8 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 ZZZ3 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 RHNO1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 PYM1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 STK33 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 TOR1AIP2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 GEMIN8 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 TP53TG3 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
LRRK2 RAB12 24234451 25348397 26824392 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
LRRK2 VN1R1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 TAS2R60 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 NCBP3 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 RHBDD1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 SMTNL2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 JHY 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 C1ORF87 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 UBXN10 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 TGIF2LX 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 CYREN 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 SPATS2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 KCTD18 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 CDKL3 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 WT1-AS 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 LARP4 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 SERF1A 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 KDM4D 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 TTLL1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 GTSF1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 FAM184A 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 SKA3 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
PSME3IP1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
LRRK2 LRRK2 16321986 18230735 18397888 19712061 19733152 20515039 21073465 22363216 22952686 23220480 23241358 24234451 24275654 24591621 24904275 26824392 27013965 27357661 phosphorylation reaction,colocalization,physical association,self interaction affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,cross-linking study,dynamic light scattering,electron microscopy,light scattering,molecular sieving,pull down,x-ray crystallography,blue native page,protein kinase assay IntAct
ENDOA LRRK2 22998870 24234451 phosphorylation reaction protein kinase assay IntAct
SGG LRRK2 20881132 24234451 physical association anti tag coimmunoprecipitation IntAct
AHNAK LRRK2 24234451 30021884 physical association cross-linking study IntAct
PRKACA LRRK2 21378983 22335897 22952710 23937259 24351927 27898060 N/A N/A OmniPath
LRRK2 SNAPIN 23949442 27898060 inhibition N/A OmniPath
LRRK2 AKT1 21658387 24916379 27898060 stimulant N/A OmniPath
LRRK2 TP53 26384650 27898060 N/A N/A OmniPath
LRRK2 DVL3 19625296 23754980 27898060 stimulant N/A OmniPath
LRRK2 MAPT 22303461 27898060 inhibition N/A OmniPath
LRRK2 SNCA 19576176 23183827 27898060 stimulant N/A OmniPath
ARHGEF7 LRRK2 21048939 27898060 stimulant N/A OmniPath
LRRK2 ARHGEF7 21048939 27898060 stimulant N/A OmniPath
LRRK2 MSN 17447891 20642453 22952686 23241358 24351927 24695735 24904275 25009464 27898060 8537411 stimulant N/A OmniPath
LRRK2 SH3GL2 22998870 25501810 27898060 inhibition N/A OmniPath
LRRK2 ARFGAP1 22363216 22423108 27898060 inhibition N/A OmniPath
ARFGAP1 LRRK2 22363216 22423108 27898060 stimulant N/A OmniPath
LRRK2 SH3GL1 22998870 27898060 inhibition N/A OmniPath
LRRK2 PLN 15528241 17913704 27898060 N/A N/A OmniPath
LRRK2 RAB5B 18445495 25605758 26355680 27898060 N/A N/A OmniPath
LRRK2 RPS15 24725412 27898060 N/A N/A OmniPath

Visualization










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