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GENE：PDPK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDPK1
FullNmae 3-phosphoinositide dependent protein kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8816
EnsembleID ENSG00000140992
Uniprot O15530

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDPK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDPK1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PDPK1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PDPK1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDPK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDPK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDPK1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PDPK1 GO:0003323,GO:0004674,GO:0004674,GO:0004674,GO:0004676,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006468,GO:0006469,GO:0006972,GO:0007173,GO:0008286,GO:0010518,GO:0010667,GO:0014069,GO:0016004,GO:0016020,GO:0016310,GO:0016477,GO:0018105,GO:0018107,GO:0019722,GO:0030036,GO:0030512,GO:0031295,GO:0031410,GO:0032148,GO:0032869,GO:0034122,GO:0035556,GO:0035556,GO:0042995,GO:0043122,GO:0043274,GO:0043304,GO:0043536,GO:0045766,GO:0046777,GO:0048009,GO:0051281,GO:0051897,GO:0071364,GO:0097191,GO:0106310,GO:1903078,GO:1903672,GO:1905564,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDPK1 hsa:5170 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04210 Apoptosis - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04360 Axon guidance - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04510 Focal adhesion - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04931 Insulin resistance - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05213 Endometrial cancer - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05215 Prostate cancer - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PDPK1 hsa:5170 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PDPK1 PRKCQ 10652356 11687500 11747822 12670391 15214048 15536066 15802604 16606694 17544292 17548359 17680028 18784374 18802401 19109239 19122654 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PDPK1 AKT1 10226025 10698680 11278835 11313365 11438723 11445557 11687500 11747822 11825911 12149249 12670391 14500673 15505410 15802604 17680028 18802401 18988627 19109239 19122654 21071413 23331499 26192618 9368760 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
PDPK1 SGK1 10191262 10357815 11500365 11687500 11747822 12387817 12670391 15802604 16286006 17680028 18802401 19109239 19122654 20932932 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink
PDPK1 PAK1 10995762 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
PDPK1 PKN2 10764742 23180781 physical association two hybrid,pull down InnateDB
PDPK1 PKN1 10764742 23180781 physical association two hybrid,pull down InnateDB
PDPK1 PRKCI 10764742 23180781 physical association two hybrid,pull down InnateDB
PDPK1 PRKCZ 10764742 23180781 physical association two hybrid,pull down InnateDB
PDPK1 PDPK1 10191262 10455013 11006271 11481331 15209375 19864428 23180781 26467481 9445476 interaction type,phosphorylation reaction,up-regulates,up-regulates activity in-gel kinase assay InnateDB,Signor
PDPK1 PIK3R1 17408603 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 PDPK1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB
PTEN PDPK1 11943559 23331499 stimulation N/A SignaLink,SignaLink
PDPK1 AKT2 15191648 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
IRS1 PDPK1 20005715 interaction type N/A PSP
PXN PDPK1 20005715 interaction type N/A PSP,SignaLink
YWHAH PDPK1 20005715 interaction type N/A PSP
YWHAQ PDPK1 20005715 interaction type N/A PSP
YWHAQ PDPK1 12177059 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 PDPK1 15802620 18988627 20005715 20005715 N/A N/A SignaLink
YWHAH PDPK1 12177059 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 PDPK1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PDPK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 PDPK1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PDPK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PDPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN PDPK1 19910471 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 PDPK1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016D2D4 PDPK1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EC1BE PDPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 PDPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC PDPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA PDPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA PDPK1 23446348 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00004505E4 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PDPK1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 PDPK1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 PDPK1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 PDPK1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 PDPK1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000134ADC PDPK1 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA PDPK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 PDPK1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 PDPK1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 PDPK1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD PDPK1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000450F92 PDPK1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF PDPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 PDPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PDPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PDPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 PDPK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F8 PDPK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 PDPK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 PDPK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED PDPK1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC PDPK1 22135298 phosphorylation N/A PhosphoSite
CDK1 PDPK1 22135298 phosphorylation N/A PhosphoSite
IGF1R PDPK1 22135298 phosphorylation N/A PhosphoSite
PDPK1 SGK2 22135298 phosphorylation N/A PhosphoSite
PDPK1 PDPK1 22135298 phosphorylation N/A PhosphoSite
PDPK1 PKN1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 EPAS1 22135298 phosphorylation N/A PhosphoSite
PDPK1 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDPK1 AKT2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 ITGB3 22135298 phosphorylation N/A PhosphoSite
PDPK1 PRKCZ 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 RPS6KB1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 AKT1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 PIP5K1C 22135298 phosphorylation N/A PhosphoSite
PDPK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
PDPK1 SGK3 22135298 phosphorylation N/A PhosphoSite
PDPK1 AKT3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 SGK1 22135298 phosphorylation N/A PhosphoSite
PDPK1 MAP2K2 22135298 phosphorylation N/A PhosphoSite
PDPK1 PAK1 22135298 phosphorylation N/A PhosphoSite
PDPK1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
PDPK1 PKN2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 PRKCE 22135298 phosphorylation N/A PhosphoSite
MAP3K5 PDPK1 22135298 phosphorylation N/A PhosphoSite
RET PDPK1 22135298 phosphorylation N/A PhosphoSite
PRKCD PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 PRKCD 25361965 interaction type N/A PTMCode2
PKN1 PDPK1 25361965 interaction type N/A PTMCode2
PRKCI PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 PRKCI 25361965 interaction type N/A PTMCode2
PRKCQ PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 PRKCQ 25361965 interaction type N/A PTMCode2
RPS6KB2 PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 RPS6KB2 25361965 interaction type N/A PTMCode2
AKT3 PDPK1 25361965 interaction type N/A PTMCode2
RPS6KB1 PDPK1 25361965 interaction type N/A PTMCode2
IRS1 PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 IRS1 25361965 interaction type N/A PTMCode2
AKT1 PDPK1 25361965 interaction type N/A PTMCode2
AKTIP PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 AKTIP 25361965 interaction type N/A PTMCode2
ILK PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 ILK 25361965 interaction type N/A PTMCode2
PKN2 PDPK1 25361965 interaction type N/A PTMCode2
PRKCZ PDPK1 25361965 interaction type N/A PTMCode2
AKT2 PDPK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSPA8 PDPK1 25348397 N/A physical interaction ComPPI
IGHG1 PDPK1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BCL2L1 PDPK1 25348397 N/A coimmunoprecipitation ComPPI
BLMH PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KATNBL1 PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK1 PDPK1 25348397 N/A in vitro ComPPI
PRKCQ PDPK1 25348397 N/A physical interaction ComPPI
PTK2B PDPK1 14525934 14585963 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB PDPK1 24234451 25348397 26593251 association coimmunoprecipitation ComPPI,IntAct
MAPK8 PDPK1 25348397 N/A physical interaction ComPPI
SRC PDPK1 11481331 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPRO PDPK1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
SND1 PDPK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCD PDPK1 11381116 11781095 14525934 25348397 9748166 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PRKCE PDPK1 10945988 11062054 12640464 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN22 PDPK1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PKN1 PDPK1 10753910 10764742 10792047 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PRKACA PDPK1 10698939 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PKN2 PDPK1 10753910 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SDC2 PDPK1 25348397 N/A physical interaction ComPPI
SLC9A3R2 PDPK1 12387817 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HSP90AA1 PDPK1 11779851 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GIT1 PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITGB3 PDPK1 10896934 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ILK PDPK1 11313365 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDPK1 PRKCB 11376011 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDPK1 PRKCZ 10357815 10764742 11222751 11781095 14500673 14525934 25348397 9748166 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PDPK1 RPS6KA3 10856237 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PDPK1 MTOR 11438723 14525934 24234451 25348397 physical association beta lactamase complementation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
PDPK1 YWHAH 12177059 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PDPK1 RPS6KA1 10480933 14525934 25348397 9430688 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PDPK1 SGK1 10191262 10357815 14525934 17314099 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PDPK1 SGK2 10548550 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDPK1 SGK3 10548550 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDPK1 AKT3 12162751 14525934 25348397 9512493 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PDPK1 AKTIP 14525934 14749367 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PDPK1 RPS6KB1 10601311 11438723 14525934 24234451 25348397 9271440 9427642 9445476 physical association beta lactamase complementation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
PDPK1 RPS6KB2 11733037 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDPK1 CARD11 14525934 15802604 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PDPK1 IRS1 14525934 15802620 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PDPK1 PXN 25348397 N/A in vitro ComPPI
PDPK1 STRAP 14525934 16251192 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDPK1 PRSS23 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PDPK1 CDAN1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDPK1 AKT1 10226025 10698680 11278835 11438723 11445557 11825911 12149249 14500673 14525934 21775285 23397142 24234451 25348397 26256536 9368760 phosphorylation reaction,physical association anti bait coimmunoprecipitation,beta lactamase complementation,experimental interaction detection,phosphorylation reaction,physical interaction,protein kinase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PDPK1 AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PDPK1 G3BP1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDPK1 TBL2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDPK1 PA2G4 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDPK1 PEA15 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 PRXL2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 ZNF133 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 SBF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 PNO1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 DDIT4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 SMARCB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 WDCP 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 XRCC6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 TCAP 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 PHAX 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 ZC3HC1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 LUC7L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDPK1 APP 25348397 N/A physical interaction ComPPI
PDPK1 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PDPK1 ZDHHC17 25348397 N/A physical interaction ComPPI
PDPK1 SERPINA4 25348397 N/A physical interaction ComPPI
PDPK1 CPA4 25348397 N/A physical interaction ComPPI
PDPK1 FAM199X 25348397 N/A physical interaction ComPPI
PDPK1 CSK 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PDPK1 APBB3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PDPK1 XPO1 25348397 N/A physical interaction ComPPI
PDPK1 MAP3K7 25348397 N/A physical interaction ComPPI
PDPK1 SCRN2 25348397 N/A physical interaction ComPPI
PDPK1 ADAM17 25348397 N/A phosphorylation reaction,protein kinase assay,protein kinase assay ComPPI
PDPK1 PNN 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PDPK1 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PTPRG 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PTPRB 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PDPK1 PPP2R2B 21075311 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PDPK1 ULK1 24234451 25348397 26593251 physical association coimmunoprecipitation ComPPI,IntAct
POLDIP2 PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKM PDPK1 25348397 N/A protein kinase assay ComPPI
YWHAQ PDPK1 12177059 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCI PDPK1 10764742 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
XPO7 PDPK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WDR5 PDPK1 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
PDPK1 RALGDS 11889038 14525934 N/A experimental interaction detection HPRD
PDPK1 PDPK1 10455013 11481331 14525934 15144186 20562859 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
TANK PDPK1 24234451 30561431 association virotrap IntAct
PDPK1 ROCK1 18204440 27898060 N/A N/A OmniPath
SRC PDPK1 11481331 14585963 16314505 20643654 27898060 stimulant N/A OmniPath
PDPK1 PRKACA 10698939 12372837 16765046 17192257 20137943 20481595 20732331 21774789 27898060 stimulant N/A OmniPath
PDPK1 PRKCA 10698939 15209375 27898060 9889098 stimulant N/A OmniPath
PDPK1 SYN1 15822905 27898060 N/A N/A OmniPath
PDPK1 PRKCB 11376011 15209375 17115692 27898060 stimulant N/A OmniPath
PDPK1 PRKCE 10945988 11062054 11964154 12640464 27898060 stimulant N/A OmniPath
PTEN PDPK1 11943559 27898060 stimulant N/A OmniPath
PDPK1 PLK1 23887393 27898060 stimulant N/A OmniPath
PDPK1 PRKCD 11381116 11781095 18669648 19664995 20058876 27898060 9748166 stimulant N/A OmniPath
RET PDPK1 12738763 27898060 N/A N/A OmniPath
PDPK1 EPAS1 17024177 27898060 N/A N/A OmniPath
PDPK1 MAP2K1 15175348 27898060 stimulant N/A OmniPath
PDPK1 RPS6KA1 10480933 17906627 18767875 20058876 27898060 9430688 stimulant N/A OmniPath
RPS6KA1 PDPK1 10480933 17906627 27898060 9430688 N/A N/A OmniPath
IGF1R PDPK1 11054117 11481331 12738763 18024423 20044479 20643654 27898060 stimulant N/A OmniPath
PDPK1 MAP2K2 15175348 27898060 stimulant N/A OmniPath
PDPK1 AKT1 10207050 10226025 10438924 10698680 11042193 11278835 11313365 11438723 11445557 11500365 11598012 11825911 12149249 12167717 12808134 14500673 14993273 15718470 18456494 20333297 20481595 21775285 21798082 22569334 23397142 27898060 7722458 8630736 8978681 9094314 9104825 9169478 9252186 9368760 9512493 9642236 9868760 stimulant N/A OmniPath
PDPK1 MAP3K5 11154276 14500571 15094778 15755722 27898060 N/A N/A OmniPath
MAP3K5 PDPK1 22544756 27898060 N/A N/A OmniPath
PDPK1 PRKCG 15209375 17053865 27898060 stimulant N/A OmniPath
PDPK1 PRKCQ 15802604 27898060 stimulant N/A OmniPath
PDPK1 MAPK14 10781613 15674326 15735648 27898060 7750576 N/A N/A OmniPath
PDPK1 PRKCZ 10075713 10357815 10764742 11141077 11222751 11781095 12781924 12887331 14500673 15314172 16051884 16129678 16943418 17335005 18691976 20332120 21946537 27898060 9748166 9768361 stimulant N/A OmniPath
PRKCZ PDPK1 10357815 10764742 11141077 11222751 11781095 14500673 27898060 9748166 N/A N/A OmniPath
PDPK1 PIK3R1 17408603 27898060 N/A N/A OmniPath
PDPK1 RPS6KA3 10480933 10856237 17906627 19956600 25241761 27898060 stimulant N/A OmniPath
RPS6KA3 PDPK1 10856237 17906627 25241761 27898060 stimulant N/A OmniPath
PDPK1 PAK1 10551809 10995762 11604394 27898060 stimulant N/A OmniPath
PDPK1 AKT3 10208883 12162751 23603119 27898060 9512493 stimulant N/A OmniPath
PDPK1 SGK1 10191262 10357815 11500365 12023960 12387817 15209375 17314099 17916563 22042038 27898060 stimulant N/A OmniPath
PDPK1 CARD11 15802604 21900206 27898060 stimulant N/A OmniPath
PDPK1 PRKCI 10764742 27898060 stimulant N/A OmniPath
PRKCI PDPK1 10764742 27898060 N/A N/A OmniPath
PDPK1 RPS6KA2 10480933 17192257 17906627 19369195 27898060 stimulant N/A OmniPath
RPS6KA2 PDPK1 17906627 27898060 N/A N/A OmniPath
PDPK1 MAPT 14761950 15822905 16443603 16923168 17287340 18220336 18599021 19413330 19451179 19690332 21327254 27898060 N/A N/A OmniPath
PDPK1 AKT2 10822383 11359783 12048203 12434148 15456405 15743829 15890450 20059950 27898060 9374542 9512493 stimulant N/A OmniPath
INSR PDPK1 11481331 14585963 16314505 27898060 N/A N/A OmniPath
PDPK1 PKN2 10698939 10753910 10764742 10792047 11781095 15302935 16219676 18669648 19723632 26296974 27898060 stimulant N/A OmniPath
PKN2 PDPK1 10698939 10753910 10764742 11781095 16219676 27898060 N/A N/A OmniPath
PDPK1 RPS6KB1 10601311 11438723 11914378 12023960 12183455 14993219 15208671 15388791 17347671 17848913 19864428 21087210 21986499 27898060 9271440 9427642 9445476 stimulant N/A OmniPath
PDPK1 RPS6KB2 11733037 15209375 27898060 9445476 stimulant N/A OmniPath
PDPK1 PDCD4 16357133 27898060 N/A N/A OmniPath
PDPK1 PKN1 10467162 10753910 10764742 10792047 18669648 27898060 stimulant N/A OmniPath
PKN1 PDPK1 10753910 10764742 10792047 27898060 N/A N/A OmniPath
PIK3CG PDPK1 27898060 9768361 stimulant N/A OmniPath
PDPK1 ITGB3 10896934 18578522 27898060 stimulant N/A OmniPath
PDPK1 SGK3 10548550 15209375 16790420 27898060 stimulant N/A OmniPath
PDPK1 PDHA1 11092882 11485553 11486000 16436377 17065338 17474719 17957032 19081061 21680880 22195962 22289032 23138570 23685455 24148194 24858472 25053415 25104357 25237928 25243911 25257871 25404640 25995437 26378042 26483203 26497997 26506913 27898060 7782287 N/A N/A OmniPath
PPP2R2B PDPK1 21075311 27898060 inhibition N/A OmniPath
PDPK1 SGK2 10548550 15209375 27898060 stimulant N/A OmniPath
MELK PDPK1 22544756 27898060 N/A N/A OmniPath

Visualization










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