GENE：TPCN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TPCN1 |
| FullNmae | two pore segment channel 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18182 |
| EnsembleID | ENSG00000186815 |
| Uniprot | Q9ULQ1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TPCN1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TPCN1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TPCN1 | GO:0005244,GO:0005248,GO:0005515,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005768,GO:0010008,GO:0010008,GO:0010508,GO:0015280,GO:0019905,GO:0031901,GO:0034220,GO:0034765,GO:0035725,GO:0036019,GO:0042802,GO:0042803,GO:0051209,GO:0055038,GO:0072345,GO:0072345,GO:0075509,GO:0080025,GO:0097682 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TPCN1 | hsa:53373 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TPCN1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | TPCN1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | TPCN1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TPCN1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | TPCN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HAX1 | TPCN1 | 24188827 24234451 25348397 | physical association | two hybrid,pull down | ComPPI,IntAct |
| TNFRSF1A | TPCN1 | 25348397 | N/A | physical interaction | ComPPI |
| MTOR | TPCN1 | 23394946 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TNFRSF19 | TPCN1 | 25348397 | N/A | physical interaction | ComPPI |
| LPAR1 | TPCN1 | 25348397 | N/A | physical interaction | ComPPI |
| TPCN1 | TPCN2 | 21903581 24234451 25348397 27898060 | colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,fluorescence microscopy | ComPPI,IntAct,OmniPath |