GENE：GATA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GATA4 |
| FullNmae | GATA binding protein 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4173 |
| EnsembleID | ENSG00000136574 |
| Uniprot | P43694 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GATA4 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GATA4 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GATA4 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GATA4 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GATA4 | GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001216,GO:0001228,GO:0001228,GO:0001947,GO:0003162,GO:0003180,GO:0003190,GO:0003197,GO:0003197,GO:0003208,GO:0003215,GO:0003281,GO:0003289,GO:0003290,GO:0003677,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0006355,GO:0007267,GO:0007492,GO:0008270,GO:0008584,GO:0008584,GO:0009410,GO:0009612,GO:0010507,GO:0010575,GO:0010667,GO:0016604,GO:0019901,GO:0030513,GO:0033189,GO:0035054,GO:0036302,GO:0042060,GO:0043565,GO:0045165,GO:0045766,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0048617,GO:0051525,GO:0051896,GO:0060290,GO:0060413,GO:0060575,GO:0061026,GO:0061049,GO:0061629,GO:0061629,GO:0070374,GO:0070410,GO:0071333,GO:0086004,GO:0090575,GO:1902176,GO:1990837,GO:2001234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GATA4 | hsa:2626 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| GATA4 | hsa:2626 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| GATA4 | hsa:2626 | path:hsa04530 | Tight junction - Homo sapiens (human) |
| GATA4 | hsa:2626 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA4 | AR | 17011549 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GATA4 | COL1A2 | 16091368 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GATA4 | HAMP | 21609320 21971825 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | GATA4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | GATA4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GATA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HAND2 | GATA4 | 11994297 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HEY1 | GATA4 | 16199874 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HEY2 | GATA4 | 16199874 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | GATA4 | 23239811 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NANOG | GATA4 | 15983365 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NKX2-5 | GATA4 | 19479054 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000012A1DD | GATA4 | 17875710 23558708 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr | TarBase |
| URS000003ABC4 | GATA4 | 22219180 25416803 | mrna cleavage,inhibition | western blot,northern blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00000EED18 | GATA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000171525 | GATA4 | 24365599 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NR5A1 | GATA4 | 10446911 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| MAPK1 | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| EZH2 | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| SP1 | GATA4 | 14988427 21184844 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| MAPK3 | GATA4 | 11585926 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EP300 | GATA4 | 11481322 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PIAS1 | GATA4 | 14525934 15337742 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| SRF | GATA4 | 11003651 11158291 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MED1 | GATA4 | 11724781 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| HAND2 | GATA4 | 11994297 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| KDM6A | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| ID3 | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | NKX2-5 | 10948187 14525934 25348397 9312027 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| GATA4 | MEF2C | 10790371 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GATA4 | CRIP2 | 12530967 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GATA4 | TBX5 | 12845333 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| GATA4 | ZFPM2 | 10801815 11297508 14525934 18252717 25348397 27898060 9927675 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| GATA4 | NFATC4 | 14525934 25348397 9568714 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| GATA4 | JARID2 | 14525934 15542826 22215809 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| GATA4 | MDC1 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | ID1 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | ID2 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | ALX4 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | ZBTB3 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | EZH1 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | SUZ12 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | FOXE1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| GATA4 | KLF13 | 17053787 24234451 25348397 | physical association | anti tag coimmunoprecipitation,pull down | ComPPI,IntAct |
| GATA4 | KSR1 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HDAC2 | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| GATA4 | FOS | 14525934 27898060 9207128 | N/A | experimental interaction detection | HPRD,OmniPath |
| GATA4 | H1-5 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| UBC | GATA4 | 22713603 22734001 27898060 | N/A | N/A | OmniPath |
| PRKACA | GATA4 | 16109788 27898060 | N/A | N/A | OmniPath |
| CDK4 | GATA4 | 21447557 27898060 | N/A | N/A | OmniPath |
| GSK3B | GATA4 | 11719519 27898060 | N/A | N/A | OmniPath |