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GENE：KDM4A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KDM4A
FullNmae lysine demethylase 4A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:22978
EnsembleID ENSG00000066135
Uniprot O75164

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KDM4A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KDM4A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KDM4A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KDM4A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
KDM4A GO:0000785,GO:0001650,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005721,GO:0005829,GO:0006338,GO:0008270,GO:0010468,GO:0010507,GO:0010628,GO:0010629,GO:0014898,GO:0030263,GO:0031625,GO:0031667,GO:0032452,GO:0032454,GO:0035064,GO:0045666,GO:0045892,GO:0048712,GO:0051864,GO:0051864,GO:0140681,GO:0140684

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KDM4A ASCL2 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A PANX2 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A RHOQ 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A PPIC 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A CDC6 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A GP5 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB
KDM4A CHD5 23168260 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KDM4A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 KDM4A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 KDM4A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 KDM4A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 KDM4A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 KDM4A 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 KDM4A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 KDM4A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR KDM4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 KDM4A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000017EA6A KDM4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA KDM4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 KDM4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 KDM4A 24802408 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001E3523 KDM4A 25416803 26461474 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
H3C1 KDM4A 25361965 interaction type N/A PTMCode2
KDM4A H3C1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
WAS KDM4A 25348397 N/A physical interaction ComPPI
MCM5 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
MCM2 KDM4A 23871696 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
H4C1 KDM4A 16415788 22373579 24234451 25348397 N/A far western blotting,isothermal titration calorimetry,pull down,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
EPHB2 KDM4A 25348397 N/A physical interaction ComPPI
RB1 KDM4A 15927959 25348397 27898060 N/A physical interaction ComPPI,OmniPath
AR KDM4A 25348397 N/A physical interaction ComPPI
HDAC3 KDM4A 25348397 N/A physical interaction ComPPI
POLA1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
NCOR1 KDM4A 14527417 16024779 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DUT KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
SSBP1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RFC2 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
POLE KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
DNAJA3 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
CAPZA1 KDM4A 25348397 N/A physical interaction ComPPI
CACYBP KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RNF8 KDM4A 25348397 N/A physical interaction ComPPI
HUWE1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RNF168 KDM4A 25348397 N/A physical interaction ComPPI
CUL1 KDM4A 23871696 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
H3-4 KDM4A 17567753 24234451 25348397 27898060 demethylation reaction surface plasmon resonance,x-ray crystallography,demethylase assay ComPPI,IntAct,OmniPath
WRNIP1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
POLD1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
TRRAP KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
STK11 KDM4A 25348397 N/A physical interaction ComPPI
CCL22 KDM4A 25348397 N/A physical interaction ComPPI
H3C1 KDM4A 16415788 16601153 16603238 16732292 24234451 25348397 27898060 colocalization far western blotting,pull down,surface plasmon resonance,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
UPF1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
H3-3A KDM4A 25348397 N/A physical interaction ComPPI
RFC5 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
DDB1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RFC4 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
MCM3 KDM4A 23871696 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
MCM4 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
FBXL4 KDM4A 25348397 N/A physical interaction ComPPI
MCM7 KDM4A 23871696 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
ZNF414 KDM4A 25348397 N/A physical interaction ComPPI
KDM4B KDM4A 25348397 N/A physical interaction ComPPI
ABHD5 KDM4A 25348397 N/A physical interaction ComPPI
TP53 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
NXF1 KDM4A 25348397 N/A physical interaction ComPPI
HDAC1 KDM4A 25348397 N/A physical interaction ComPPI
MOV10 KDM4A 25348397 N/A physical interaction ComPPI
CDK1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
KDM4A WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KDM4A KDM4C 25348397 N/A physical interaction ComPPI
KDM4A ZNF131 25348397 N/A physical interaction ComPPI
KDM4A ERG 24234451 25348397 27109047 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
SU(VAR)205 KDM4A 25348397 N/A physical interaction ComPPI
KDM4A BCL2L11 18022353 27898060 inhibition N/A OmniPath
KDM4A AR 17555712 27898060 stimulant N/A OmniPath
KDM4A H1-4 19144645 27898060 stimulant N/A OmniPath

Visualization










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