Gene Information gene info

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GENE：ATG12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG12
FullNmae autophagy related 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:588
EnsembleID ENSG00000145782
Uniprot O94817

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG12 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATG12 GO:0000045,GO:0000045,GO:0000045,GO:0000422,GO:0005515,GO:0005654,GO:0005776,GO:0005829,GO:0006501,GO:0016236,GO:0016236,GO:0030670,GO:0032480,GO:0032991,GO:0034045,GO:0034045,GO:0034045,GO:0034274,GO:0034274,GO:0043231,GO:0044804,GO:0045824,GO:0050687,GO:1901096,GO:1904973,GO:1990234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG12 hsa:9140 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
ATG12 hsa:9140 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG12 hsa:9140 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG12 hsa:9140 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
ATG12 hsa:9140 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
ATG12 hsa:9140 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATG5 ATG12 22093031 22166994 23030059 23301705 23725295 24070470 24257061 26192618 interaction type N/A ACSN
ATG7 ATG12 11096062 23180781 26192618 interaction type,physical association two hybrid ACSN,InnateDB
ATG12 ATG3 12207896 22093031 22166994 23030059 23180781 23301705 23725295 24070470 24257061 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
ATG12 DDX58 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDX58 ATG12 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG12 IFIH1 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFIH1 ATG12 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG12 MAVS 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS ATG12 17709747 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG10 ATG12 16963840 23180781 covalent binding comigration in sds page InnateDB
ATG12 ATG5 12207896 23180781 covalent binding anti tag coimmunoprecipitation InnateDB
ATG3 ATG12 12207896 23180781 physical association anti tag coimmunoprecipitation InnateDB
WDFY3 ATG12 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG16L1 ATG12 20639872 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG12 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
TECPR1 ATG12 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ATG12 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 ATG12 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ATG12 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATG12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATG12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATG12 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002152A8 ATG12 20371350 22647547 22743998 25416803 mrna cleavage,inhibition experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000183BED ATG12 23916944 25416803 25996293 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000005CF5F ATG12 23274497 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000039E1E1 ATG12 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037E170 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F ATG12 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF ATG12 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ATG12 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 ATG12 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 ATG12 25416803 27630106 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000012A1DD ATG12 25416803 26416454 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00006DE17B ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000486E0B ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CCD18 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B0E50 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075CC78 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000246356 ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA ATG12 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNRPB2 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DDX6 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CRX ATG12 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP4-12 ATG12 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
POP7 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
H2BC4 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MRM3 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KRT31 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3E ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MRPL23 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MDFI ATG12 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SERTAD1 ATG12 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SF3B1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PLSCR1 ATG12 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CAV1 ATG12 25348397 N/A physical interaction ComPPI
MCL1 ATG12 25348397 N/A physical interaction ComPPI
FADD ATG12 25348397 N/A physical interaction ComPPI
EXOC4 ATG12 21241894 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RALB ATG12 21241894 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EPRS1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
XPO1 ATG12 25348397 N/A physical interaction ComPPI
HTT ATG12 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LMNB1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SERTAD2 ATG12 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SF3A1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAP ATG12 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AUP1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2 ATG12 25348397 N/A physical interaction ComPPI
HNRNPUL1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC37 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BECN1 ATG12 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TGM3 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RB1CC1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3A ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HNRNPAB ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG3 ATG12 17353931 20562859 23202584 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,isothermal titration calorimetry,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach ComPPI,IntAct
ATG7 ATG12 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,in vivo ComPPI,IntAct
HNRNPA3 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 ATG10 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
ATG12 PTK2 25348397 N/A physical interaction ComPPI
ATG12 DHX36 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 OTUD4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 ATG5 17353931 20562859 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 ATG16L1 17353931 20562859 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 TECPR1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 MAP1B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 WDFY3 25348397 N/A physical interaction ComPPI
ATG12 APP 25348397 N/A physical interaction ComPPI
ATG12 WIPI2 25348397 N/A physical interaction ComPPI
ATG12 MAVS 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATG12 DDX58 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATG12 IFIH1 17709747 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG12 CHTOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 EPB41L5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 MOV10 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 RPL36 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 HNRNPA0 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 CCDC59 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 SUN2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 SERBP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 RPS29 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 KRT82 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 DOCK9 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ATG12 WIPI1 23088497 24234451 25348397 27898060 colocalization confocal microscopy ComPPI,IntAct,OmniPath
ATG12 IER2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MRPS23 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATG12 ATG16L2 10406794 11897782 17986448 27898060 N/A N/A OmniPath
ATG3 ATG12 11825910 12207896 17353931 17986448 20562859 20723759 23202584 24186333 27898060 N/A N/A OmniPath
ATG7 ATG12 10233150 11096062 11100732 11139573 11265251 11890701 12482611 12965207 18704115 20562859 27898060 9759731 stimulant N/A OmniPath
ATG12 MAVS 17709747 27898060 N/A N/A OmniPath
MAVS ATG12 17709747 27898060 N/A N/A OmniPath
ATG12 ATG16L1 17353931 20562859 20639872 27898060 N/A N/A OmniPath
ATG12 ATG10 10508157 12482611 16963840 17353931 26186194 27898060 N/A N/A OmniPath
ATG10 ATG12 10508157 11265251 12482611 16963840 17353931 18704115 26186194 27898060 stimulant N/A OmniPath
ATG12 DDX58 17709747 27898060 N/A N/A OmniPath
DDX58 ATG12 17709747 27898060 N/A N/A OmniPath
ATG12 IFIH1 17709747 27898060 N/A N/A OmniPath
IFIH1 ATG12 17709747 27898060 N/A N/A OmniPath
WDFY3 ATG12 20417604 27898060 stimulant N/A OmniPath
ATG12 ATG5 10406794 11139573 11149920 11265251 11825910 12207896 12482611 12665549 12890687 17145710 17353931 20562859 22342342 23064152 23202584 23238393 25461810 27898060 9759731 9852036 stimulant N/A OmniPath
ATG5 ATG12 10406794 11139573 11149920 11265251 11825910 12207896 12482611 12665549 12890687 17145710 17353931 20562859 22342342 23064152 23202584 23238393 25461810 27898060 9759731 9852036 N/A N/A OmniPath
TECPR1 ATG12 20562859 21575909 22342342 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C4000 ATG12 27087310 direct interaction,inhibition N/A NPInter

Visualization










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