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GENE：ATG4A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG4A
FullNmae autophagy related 4A cysteine peptidase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16489
EnsembleID ENSG00000101844
Uniprot Q8WYN0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG4A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATG4A GO:0000045,GO:0005515,GO:0005737,GO:0006508,GO:0006629,GO:0006914,GO:0008234,GO:0015031,GO:0019786,GO:0051697

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG4A hsa:115201 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG4A hsa:115201 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GABARAPL2 ATG4A 17347651 23180781 cleavage reaction protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ATG4A 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ATG4A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF ATG4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATG4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATG4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ATG4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ATG4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 ATG4A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 ATG4A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D ATG4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 ATG4A 25416803 26313360 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
GABARAPL1 ATG4A 25361965 interaction type N/A PTMCode2
ATG4A GABARAPL1 25361965 interaction type N/A PTMCode2
GABARAPL2 ATG4A 25361965 interaction type N/A PTMCode2
ATG4A GABARAPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GABARAPL2 ATG4A 12473658 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP1LC3B ATG4A 20010802 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SYN1 ATG4A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 ATG4A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3A ATG4A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PDK1 ATG4A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG4A ATG101 25348397 N/A physical interaction ComPPI
ATG4A GABARAPL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATG4A CDKL3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATG4A BCAS4 25348397 N/A physical interaction ComPPI
ATG4A LCN15 25348397 N/A physical interaction ComPPI
ATG4A NUF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG4A USP43 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG4A BOD1 25348397 N/A physical interaction ComPPI
ATG4A HSPB6 25348397 N/A physical interaction ComPPI
ZFP3 ATG4A 22939629 30476227 colocalization biochemical TheBiogrid
TP63 ATG4A 22356768 27898060 N/A N/A OmniPath
ATG4A GABARAPL2 12473658 17347651 27898060 stimulant N/A OmniPath

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