GENE：IL1A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IL1A |
| FullNmae | interleukin 1 alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5991 |
| EnsembleID | ENSG00000115008 |
| Uniprot | P01583 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IL1A | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1A | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| IL1A | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1A | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| IL1A | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1A | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1A | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IL1A | GO:0001660,GO:0001666,GO:0001819,GO:0002248,GO:0005125,GO:0005125,GO:0005149,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005634,GO:0005829,GO:0006883,GO:0006915,GO:0006954,GO:0006955,GO:0007283,GO:0007507,GO:0008285,GO:0009986,GO:0010193,GO:0010243,GO:0010332,GO:0010575,GO:0010628,GO:0010628,GO:0010893,GO:0019221,GO:0019221,GO:0031424,GO:0032308,GO:0032743,GO:0032743,GO:0032755,GO:0032760,GO:0032956,GO:0033092,GO:0033591,GO:0034605,GO:0035234,GO:0043123,GO:0045766,GO:0045840,GO:0045944,GO:0046330,GO:0046688,GO:0050714,GO:0050999,GO:0051781,GO:0070374,GO:0071222,GO:0097192,GO:1902624,GO:1904445,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IL1A | hsa:3552 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05162 | Measles - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05321 | Inflammatory bowel disease - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| IL1A | hsa:3552 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IL1R1 | IL1A | 23180781 8142597 | physical association | chromatography technology | InnateDB |
| IL1R2 | IL1A | 1833184 23180781 23395675 | physical association | anti tag coimmunoprecipitation,competition binding | InnateDB |
| IL1A | HAX1 | 11554782 23180781 | physical association | anti tag coimmunoprecipitation,two hybrid,far western blotting | InnateDB |
| NDN | IL1A | 12913118 23180781 | physical association | anti tag coimmunoprecipitation,two hybrid | InnateDB |
| IL1A | S100A13 | 12746488 23180781 | physical association | anti tag coimmunoprecipitation,cosedimentation in solution | InnateDB |
| RELA | IL1A | 21131967 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | IL1A | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1A | IL1A | 26467481 7964161 9565970 | bind,up-regulates activity | N/A | Signor |
| IL1A | IL1R1 | 23331499 2946959 9565970 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FOS | IL1A | 8688489 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA2 | IL1A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| JUN | IL1A | 8688489 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SP1 | IL1A | 15863387 17906119 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | IL1A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | IL1A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IL1A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | IL1A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | IL1A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | IL1A | 17612514 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | IL1A | 17612514 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | IL1A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPD | IL1A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | IL1A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002B2B5C | IL1A | 20924108 | rna interference,inhibition | array technology,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
| URS00002B2B5C | IL1A | 20924108 25416803 | mrna cleavage,inhibition | array technology,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | IL1A | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001E0AEA | IL1A | 22870299 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000005CF5F | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | IL1A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DA458 | IL1A | 25416803 26283734 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS00003380CC | IL1A | 25416803 26239639 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IL1R1 | IL1A | 25361965 | interaction type | N/A | PTMCode2 |
| IL1A | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1A | IL1R2 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1R2 | IL1A | 25361965 | interaction type | N/A | PTMCode2 |
| IL1A | S100A13 | 25361965 | interaction type | N/A | PTMCode2 |
| S100A13 | IL1A | 25361965 | interaction type | N/A | PTMCode2 |
| IL1A | CARD16 | 25361965 | interaction type | N/A | PTMCode2 |
| CARD16 | IL1A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MEOX2 | IL1A | 24234451 25348397 25910212 | physical association | two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid | ComPPI,IntAct |
| S100A13 | IL1A | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| IL1RAP | IL1A | 14525934 25348397 9820540 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP1 | IL1A | 14525934 18329368 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| HAX1 | IL1A | 11554782 14525934 16971486 24234451 25348397 25416956 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,lambda repressor two hybrid | ComPPI,HPRD,IntAct |
| NDN | IL1A | 12913118 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| KPNA6 | IL1A | 24234451 25348397 25910212 | physical association | two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CAPN1 | IL1A | 14525934 25348397 7499244 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| IL1A | IL1R1 | 14525934 25348397 2946959 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| IL1A | IL1R2 | 14525934 16971486 24234451 25241761 25348397 7878046 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,lambda repressor two hybrid,proximity ligation assay | ComPPI,HPRD,IntAct |
| IL1A | NFKBIE | 10998424 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| IL1A | SHARPIN | 21947080 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| IL1A | IL1A | 14525934 2946959 | N/A | experimental interaction detection | HPRD |
| CASP1 | IL1A | 18329368 27898060 | stimulant | N/A | OmniPath |
| IL1A | HAX1 | 11554782 25416956 27898060 | N/A | N/A | OmniPath |
| IL1A | IL1R2 | 1833184 23395675 25241761 27898060 7878046 | stimulant | N/A | OmniPath |
| IL1R2 | IL1A | 1833184 23395675 25241761 27898060 7878046 | N/A | N/A | OmniPath |
| IL1A | IL1R1 | 19479203 27898060 2946959 7964161 8142597 9565970 | stimulant | N/A | OmniPath |
| IL1A | NDN | 12913118 27898060 | N/A | N/A | OmniPath |
| IL1A | S100A13 | 12746488 27898060 | N/A | N/A | OmniPath |