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GENE：FBXL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FBXL2
FullNmae F-box and leucine rich repeat protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13598
EnsembleID ENSG00000153558
Uniprot Q9UKC9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FBXL2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FBXL2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FBXL2 GO:0005515,GO:0005516,GO:0005737,GO:0006508,GO:0010506,GO:0016020,GO:0016567,GO:0016567,GO:0019005,GO:0019903,GO:0031146,GO:0036211,GO:0036312,GO:0044830,GO:0050727,GO:0051896,GO:1900226,GO:1990756

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FBXL2 FBXO3 23180781 24123678 physical association anti tag coimmunoprecipitation InnateDB
FBXL2 NLRP3 23180781 26037928 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR FBXL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 FBXL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FBXL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D FBXL2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000005481D FBXL2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000512C88 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 FBXL2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SKP1 FBXL2 25361965 interaction type N/A PTMCode2
FBXL2 SKP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 FBXL2 25348397 N/A physical interaction ComPPI
PPP1CC FBXL2 25348397 N/A two hybrid ComPPI
RABGGTB FBXL2 25348397 N/A physical interaction ComPPI
VCP FBXL2 25348397 N/A physical interaction ComPPI
SKP1 FBXL2 10508920 10531037 19159283 22399757 23604317 24234451 25348397 26790640 27705803 27898060 association,physical association anti bait coimmunoprecipitation,physical interaction,mammalian protein protein interaction trap,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach ComPPI,IntAct,OmniPath
UBE2D1 FBXL2 25348397 N/A physical interaction ComPPI
HSP90AB1 FBXL2 22939624 24234451 25036637 25348397 association,physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
PIK3R1 FBXL2 25348397 N/A physical interaction ComPPI
UBE2G1 FBXL2 25348397 N/A physical interaction ComPPI
HSP90AA1 FBXL2 25348397 N/A physical interaction ComPPI
CUL2 FBXL2 25348397 N/A physical interaction ComPPI
CUL1 FBXL2 24234451 25348397 26790640 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC34 FBXL2 25348397 N/A physical interaction ComPPI
PTPN13 FBXL2 25348397 N/A physical interaction ComPPI
UBE2D3 FBXL2 25348397 N/A physical interaction ComPPI
COL7A1 FBXL2 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FBXL2 APP 25348397 N/A physical interaction ComPPI
FBXL2 CCND2 25348397 N/A physical interaction ComPPI
FBXL2 AURKB 25348397 N/A physical interaction ComPPI
FBXL2 HSP90AA2P 25348397 N/A physical interaction ComPPI
FBXL2 NLRP3 25348397 26037928 27898060 N/A physical interaction ComPPI,OmniPath
FBXL2 FOXM1 24234451 25348397 26790640 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXL2 YPEL3 25348397 N/A physical interaction ComPPI
FBXL2 YPEL1 25348397 N/A physical interaction ComPPI
FBXL2 ITPR3 25348397 N/A physical interaction ComPPI
FBXL2 FBXO3 24123678 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FBXL2 HACD3 18160438 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FBXL2 SUGT1 24234451 25036637 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPD1 FBXL2 24234451 30021884 physical association cross-linking study IntAct

Visualization










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