GENE：MT3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MT3 |
| FullNmae | metallothionein 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7408 |
| EnsembleID | ENSG00000087250 |
| Uniprot | P25713 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MT3 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MT3 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| MT3 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| MT3 | cuproptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MT3 | cuproptosis | 38408075 | We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1. | genes involved in Cuproptosis |
| MT3 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.17 database. |
| MT3 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| MT3 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MT3 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MT3 | GO:0001666,GO:0001934,GO:0005507,GO:0005507,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005737,GO:0005741,GO:0005829,GO:0005840,GO:0005874,GO:0006112,GO:0006829,GO:0006882,GO:0006882,GO:0008021,GO:0008270,GO:0010273,GO:0010628,GO:0010977,GO:0016209,GO:0016234,GO:0019430,GO:0030003,GO:0030003,GO:0030295,GO:0030308,GO:0030308,GO:0030424,GO:0030517,GO:0030949,GO:0032095,GO:0032148,GO:0033210,GO:0034599,GO:0034614,GO:0043197,GO:0043524,GO:0045893,GO:0045893,GO:0046870,GO:0046872,GO:0048471,GO:0050821,GO:0051354,GO:0070374,GO:0070374,GO:0070374,GO:0071276,GO:0071280,GO:0071294,GO:0071456,GO:0097450,GO:1990748,GO:2000296,GO:2000376 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | MT3 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | MT3 | 18922183 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| EGR1 | MT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MT3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | MT3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TTR | MT3 | 20646067 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction,saturation binding | ComPPI,IntAct,OmniPath |
| TERF2IP | MT3 | 21044950 24234451 25348397 | physical association | pull down,physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| MT3 | HMOX1 | 18554677 27898060 | stimulant | N/A | OmniPath |
| MT3 | NFE2L2 | 18554677 27898060 | stimulant | N/A | OmniPath |