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GENE：PGK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PGK1
FullNmae phosphoglycerate kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8896
EnsembleID ENSG00000102144
Uniprot P00558

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PGK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PGK1 cuproptosis 36341328 Further, differentially expressed genes with prognostic significance were used to construct a cuproptosis-related gene signature (PGK1, SLC52A2, SEC14L2, RAD23B, SLC16A6, CCL5, and MAL2) and scoring system. cuproptosis-related gene signature
PGK1 cuproptosis 36550822 Next, 11 hub CAGs(cuproptosis-associated genes), including COPB2, MRPL39, PGK1, PRDX1, PCMT1, MPZL3, LACTB2, HSPH1, DIP2B, DLG3, and NFKBIA, were applied to construct a novel prognostic risk signature for BR. cuproptosis-associated gene

Go Annotation:

GeneSymbol Go id
PGK1 GO:0004618,GO:0004618,GO:0004618,GO:0004618,GO:0005515,GO:0005524,GO:0005524,GO:0005615,GO:0005829,GO:0005829,GO:0006094,GO:0006094,GO:0006096,GO:0006096,GO:0016020,GO:0016310,GO:0016525,GO:0030855,GO:0031639,GO:0043531,GO:0045121,GO:0047134,GO:0061621,GO:0070062,GO:0071456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PGK1 hsa:5230 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
PGK1 hsa:5230 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PGK1 hsa:5230 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PGK1 hsa:5230 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
PGK1 hsa:5230 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIF1A PGK1 16126907 23180781 physical association electrophoretic mobility supershift assay InnateDB
ISG15 PGK1 16009940 23180781 physical association unspecified method InnateDB
PGK1 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR PGK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PGK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PGK1 18971253 19828020 8089148 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
YBX1 PGK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PGK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PGK1 18809243 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 PGK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC PGK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E PGK1 23622248 23824327 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000005481D PGK1 19536157 23622248 23824327 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000042E1F PGK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003E1A9 PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PGK1 21572407 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D PGK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C PGK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 PGK1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 PGK1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 PGK1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 PGK1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 PGK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C PGK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 PGK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE PGK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 PGK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 PGK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 PGK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C PGK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C PGK1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 PGK1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 PGK1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 PGK1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 PGK1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PGK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 PGK1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000016E46F PGK1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002C28B2 PGK1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 PGK1 22135298 phosphorylation N/A PhosphoSite
PGK1 PDK1 22135298 phosphorylation N/A PhosphoSite
ENO1 PGK1 25361965 interaction type N/A PTMCode2
PGK1 ENO1 25361965 interaction type N/A PTMCode2
ENO2 PGK1 25361965 interaction type N/A PTMCode2
PGK1 ENO2 25361965 interaction type N/A PTMCode2
HIF1A PGK1 25361965 interaction type N/A PTMCode2
PGK1 HIF1A 25361965 interaction type N/A PTMCode2
YWHAB PGK1 25361965 interaction type N/A PTMCode2
PGK1 YWHAB 25361965 interaction type N/A PTMCode2
ENO3 PGK1 25361965 interaction type N/A PTMCode2
PGK1 ENO3 25361965 interaction type N/A PTMCode2
GAPDHS PGK1 25361965 interaction type N/A PTMCode2
PGK1 GAPDHS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARPC3 PGK1 25348397 N/A physical interaction ComPPI
BAG3 PGK1 25348397 N/A physical interaction ComPPI
LDHB PGK1 25348397 N/A physical interaction ComPPI
LDHA PGK1 25348397 N/A physical interaction ComPPI
ISG15 PGK1 25348397 N/A physical interaction ComPPI
PCNA PGK1 20849852 24234451 25348397 physical association far western blotting,physical interaction ComPPI,IntAct
LCA5 PGK1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD21 PGK1 25348397 N/A physical interaction ComPPI
KEAP1 PGK1 25348397 N/A physical interaction ComPPI
MCM2 PGK1 25348397 N/A physical interaction ComPPI
PSMB2 PGK1 25348397 N/A physical interaction ComPPI
HSP90AB1 PGK1 16263121 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN PGK1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HIF1A PGK1 14525934 25348397 8089148 N/A experimental interaction detection,in vivo ComPPI,HPRD
COPS5 PGK1 25348397 N/A physical interaction ComPPI
HDAC3 PGK1 24234451 25348397 26356530 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SFPQ PGK1 25348397 N/A physical interaction ComPPI
PSMA3 PGK1 25348397 N/A physical interaction ComPPI
U2AF2 PGK1 25348397 N/A physical interaction ComPPI
NRBF2 PGK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GAPDH PGK1 14525934 20392205 22939629 24234451 25348397 26344197 27898060 8075252 9308888 physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
YWHAZ PGK1 15161933 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HSP90AA1 PGK1 25348397 N/A physical interaction ComPPI
NTRK1 PGK1 25348397 N/A physical interaction ComPPI
ENO1 PGK1 25348397 N/A physical interaction ComPPI
YBX1 PGK1 24234451 25348397 25497084 association anti bait coimmunoprecipitation ComPPI,IntAct
STIP1 PGK1 25348397 N/A physical interaction ComPPI
PSMA6 PGK1 25348397 N/A physical interaction ComPPI
TRIP6 PGK1 25348397 N/A physical interaction ComPPI
LASP1 PGK1 25348397 N/A physical interaction ComPPI
MAPK13 PGK1 19135240 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A1 PGK1 25348397 N/A physical interaction ComPPI
TUBA4A PGK1 25348397 N/A physical interaction ComPPI
CFTR PGK1 25348397 N/A physical interaction ComPPI
EWSR1 PGK1 25348397 N/A physical interaction ComPPI
AKR1B1 PGK1 25348397 N/A physical interaction ComPPI
PKM PGK1 25348397 N/A physical interaction ComPPI
YWHAQ PGK1 25348397 N/A physical interaction ComPPI
HUWE1 PGK1 25348397 N/A physical interaction ComPPI
HTATSF1 PGK1 25348397 N/A physical interaction ComPPI
HNRNPA2B1 PGK1 25348397 N/A physical interaction ComPPI
TPI1 PGK1 25348397 N/A physical interaction ComPPI
CDK2 PGK1 25348397 N/A physical interaction ComPPI
ACAA2 PGK1 25348397 N/A physical interaction ComPPI
SFN PGK1 25348397 N/A physical interaction ComPPI
YWHAE PGK1 25348397 N/A physical interaction ComPPI
HDAC6 PGK1 25348397 N/A physical interaction ComPPI
HSPH1 PGK1 14525934 14733918 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SF1 PGK1 25348397 N/A physical interaction ComPPI
CSE1L PGK1 25348397 N/A physical interaction ComPPI
MSN PGK1 25348397 N/A physical interaction ComPPI
CUL7 PGK1 25348397 N/A physical interaction ComPPI
HDAC5 PGK1 25348397 N/A physical interaction ComPPI
ALDOC PGK1 25348397 N/A physical interaction ComPPI
PGK1 SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PGK1 TNC 25348397 N/A pull down ComPPI
PGK1 PMS1 25348397 N/A physical interaction ComPPI
PGK1 ATG101 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 FOXO3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 NIPSNAP2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 PRKAG1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 PRKAG2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 SH3GLB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 UBA5 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PGK1 SIRT7 25348397 N/A physical interaction ComPPI
PGK1 ALDOA 25348397 N/A physical interaction ComPPI
PGK1 ATP5F1A 25348397 N/A physical interaction ComPPI
PGK1 OXCT1 25348397 N/A physical interaction ComPPI
PGK1 BOLA2 25348397 N/A physical interaction ComPPI
PGK1 TRAF3IP1 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PGK1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PGK1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 ASB9 25348397 N/A physical interaction ComPPI
PGK1 FUS 25348397 N/A physical interaction ComPPI
PGK1 HNRNPA1 25348397 N/A physical interaction ComPPI
PGK1 AKR1A1 25348397 N/A physical interaction ComPPI
PGK1 AKR1B10 25348397 N/A physical interaction ComPPI
PGK1 EEF1A1P5 25348397 N/A physical interaction ComPPI
PGK1 EEF2 25348397 N/A physical interaction ComPPI
PGK1 ENO2 25348397 N/A physical interaction ComPPI
PGK1 ENO3 25348397 N/A physical interaction ComPPI
PGK1 ADI1 25348397 N/A physical interaction ComPPI
PGK1 CRIP1 25348397 N/A physical interaction ComPPI
PGK1 FH 25348397 N/A physical interaction ComPPI
PGK1 HNRNPA3 25348397 N/A physical interaction ComPPI
PGK1 HNRNPD 25348397 N/A physical interaction ComPPI
PGK1 PYGL 25348397 N/A physical interaction ComPPI
PGK1 TKT 25348397 N/A physical interaction ComPPI
PGK1 TAGLN2 25348397 N/A physical interaction ComPPI
PGK1 TAGLN3 25348397 N/A physical interaction ComPPI
PGK1 CEP162 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 CENPA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 MYO5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGK1 RHOU 25348397 N/A physical interaction ComPPI
PGK1 ZNF746 25348397 N/A physical interaction ComPPI
PGK1 PGK2 25348397 N/A physical interaction ComPPI
PGK1 CYLD 25348397 N/A physical interaction ComPPI
PGK1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PGK1 TRIM25 25348397 N/A physical interaction ComPPI
PGK1 BRCA1 25348397 N/A physical interaction ComPPI
PGK1 TARDBP 25348397 N/A physical interaction ComPPI
PGK1 ELP3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PGK1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PGK1 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
PGK1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
PGK1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
PGK1 PPTC7 24234451 25348397 28330616 association pull down ComPPI,IntAct
PGK1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PGK1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB1 PGK1 25348397 N/A physical interaction ComPPI
ATF2 PGK1 22304920 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DDA1 PGK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 PGK1 16009940 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B5105 PGK1 27087310 direct interaction,inhibition N/A NPInter

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