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GENE：PIK3R4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3R4
FullNmae phosphoinositide-3-kinase regulatory subunit 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8982
EnsembleID ENSG00000196455
Uniprot Q99570

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3R4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIK3R4 GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005770,GO:0005770,GO:0005776,GO:0005829,GO:0005930,GO:0006468,GO:0006468,GO:0006622,GO:0006623,GO:0010506,GO:0015630,GO:0016020,GO:0016236,GO:0016241,GO:0030242,GO:0030670,GO:0032465,GO:0032801,GO:0034271,GO:0034272,GO:0035032,GO:0035032,GO:0036092,GO:0042149,GO:0043231,GO:0043491,GO:0045022,GO:0045324,GO:0071561,GO:0097352,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3R4 hsa:30849 path:hsa04136 Autophagy - other - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05016 Huntington disease - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PIK3R4 hsa:30849 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BECN1 PIK3R4 18843052 19050071 19270696 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
ATG14 PIK3R4 18843052 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3C3 PIK3R4 18957027 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN PIK3R4 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 PIK3R4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PIK3R4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PIK3R4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIK3R4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 PIK3R4 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS00002971AB PIK3R4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F6E49 PIK3R4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007A060 PIK3R4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 PIK3R4 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIK3C3 PIK3R4 25361965 interaction type N/A PTMCode2
PIK3R4 PIK3C3 25361965 interaction type N/A PTMCode2
PIK3R4 BECN1 25361965 interaction type N/A PTMCode2
BECN1 PIK3R4 25361965 interaction type N/A PTMCode2
ATG14 PIK3R4 25361965 interaction type N/A PTMCode2
PIK3R4 ATG14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 PIK3R4 12388762 12686597 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SNW1 PIK3R4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP43 PIK3R4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAG PIK3R4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAB PIK3R4 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NRBF2 PIK3R4 24234451 24785657 24849286 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NTRK1 PIK3R4 25348397 N/A physical interaction ComPPI
RUBCN PIK3R4 21062745 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PARD6A PIK3R4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRIT1 PIK3R4 25348397 N/A physical interaction ComPPI
XPO1 PIK3R4 25348397 N/A physical interaction ComPPI
DVL2 PIK3R4 25348397 N/A physical interaction ComPPI
YWHAE PIK3R4 25348397 N/A physical interaction ComPPI
BECN1 PIK3R4 19050071 20562859 24234451 25348397 25490155 26496610 association,physical association anti tag coimmunoprecipitation,electron microscopy,physical interaction ComPPI,IntAct
PIK3C3 PIK3R4 14525934 20562859 24234451 24785657 24849286 25348397 8999962 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ESR2 PIK3R4 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
TGOLN2 PIK3R4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PIK3R4 ATG14 11157979 18843052 19270696 19445518 20562859 22493499 23262492 24165940 24234451 25348397 25490155 27898060 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,electron microscopy,molecular sieving,pull down,physical interaction,phosphotransferase assay ComPPI,IntAct,OmniPath
PIK3R4 MAP1LC3C 25348397 N/A physical interaction ComPPI
PIK3R4 UVRAG 20562859 22493499 24234451 25348397 25490155 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PIK3R4 MOV10 25348397 N/A physical interaction ComPPI
PIK3R4 NXF1 25348397 N/A physical interaction ComPPI
PIK3R4 JADE2 25348397 N/A physical interaction ComPPI
PIK3R4 XRCC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3R4 RUBCNL 25348397 N/A physical interaction ComPPI
PIK3R4 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
H3-4 PIK3R4 24234451 30021884 physical association cross-linking study IntAct
PIK3R4 RRBP1 24234451 30021884 physical association cross-linking study IntAct
PIK3R4 CEP55 24234451 30021884 physical association cross-linking study IntAct
PIK3R4 TTN 24234451 30021884 physical association cross-linking study IntAct
ZBTB24 PIK3R4 24234451 30021884 physical association cross-linking study IntAct
PIK3R4 PIK3C3 11689570 18957027 20562859 21575909 24165940 26344197 27898060 8387919 8999962 stimulant N/A OmniPath
BECN1 PIK3R4 18843052 18957027 19050071 19270696 20562859 20711182 23878393 26496610 27898060 stimulant N/A OmniPath
UVRAG PIK3R4 18957027 27898060 stimulant N/A OmniPath

Visualization










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