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GENE：PIM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIM2
FullNmae Pim-2 proto-oncogene, serine/threonine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8987
EnsembleID ENSG00000102096
Uniprot Q9P1W9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIM2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIM2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIM2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIM2 GO:0000082,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006468,GO:0007346,GO:0008285,GO:0008637,GO:0009615,GO:0010508,GO:0016236,GO:0016239,GO:0043066,GO:0043066,GO:0043123,GO:0045893,GO:0046777,GO:0050821,GO:0050821,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIM2 hsa:11040 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIM2 hsa:11040 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF4 PIM2 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG PIM2 20098747 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PIM2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PIM2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PIM2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PIM2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002971AB PIM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BF7F9 PIM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 PIM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC PIM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D PIM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PIM2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIM2 PKM 22135298 phosphorylation N/A PhosphoSite
PIM2 CDKN1A 22135298 phosphorylation N/A PhosphoSite
PIM2 IRS1 22135298 phosphorylation N/A PhosphoSite
BAD PIM2 25361965 interaction type N/A PTMCode2
PIM2 BAD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPKOW PIM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 BAD 12954615 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM2 SOCS1 11854514 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIM2 ATXN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PIM2 CUTC 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM2 FBH1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM2 HNRNPH3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM2 RPL21 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM2 NDUFB8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM2 IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PIM2 GSK3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIM2 HSP90AA1 25348397 N/A physical interaction ComPPI
PIM2 HSP90AA2P 25348397 N/A physical interaction ComPPI
PIM2 ZNF821 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIM2 NUP98 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PIM2 PRCC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 PPIL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 TIMM13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 CLK4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 TOE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 CENATAC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIM2 MDM2 19166854 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PIM2 HSP90AB1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PIM2 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
PIM2 CDKN1A 20307683 27898060 stimulant N/A OmniPath
PIM2 BAD 10837473 10837486 10949026 12954615 16403219 18669648 18707149 19664994 20166139 27898060 9381178 9651683 inhibition N/A OmniPath
IKBKG PIM2 20098747 27898060 N/A N/A OmniPath
PIM2 PKM 24142698 27898060 N/A N/A OmniPath

Visualization










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