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GENE：REV3L

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol REV3L
FullNmae REV3 like, DNA directed polymerase zeta catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9968
EnsembleID ENSG00000009413
Uniprot O60673

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
REV3L autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
REV3L GO:0000166,GO:0000724,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006261,GO:0016035,GO:0016035,GO:0016035,GO:0042276,GO:0042276,GO:0046872,GO:0051539

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
REV3L hsa:5980 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
REV3L hsa:5980 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR REV3L 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 REV3L 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 REV3L 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 REV3L 16980608 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 REV3L 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 REV3L 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 REV3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 REV3L N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 REV3L N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 REV3L N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A REV3L N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007FBA REV3L 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000345DEB REV3L 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 REV3L 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000009262D REV3L 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000C85B2 REV3L 20371350 22349819 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00002FC5B0 REV3L 20371350 22349819 22473208 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00000ECE9C REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002AAD6B REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F REV3L 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 REV3L 20371350 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 REV3L 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F REV3L 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 REV3L 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 REV3L 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK2 REV3L 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MAD2L2 REV3L 10660610 11433034 11485998 14525934 16169844 16546083 17030609 19380376 20054135 20164194 21926160 22303021 22711820 22828282 22859296 23066099 24234451 25348397 27898060 8658138 physical association two hybrid,experimental interaction detection,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
CCND1 REV3L 25348397 N/A physical interaction ComPPI
HDAC4 REV3L 14525934 15964851 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
POLD2 REV3L 25348397 N/A physical interaction ComPPI
MEF2A REV3L 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CHEK2 REV3L 25348397 N/A physical interaction ComPPI
MAD2L1 REV3L 25348397 N/A physical interaction ComPPI
TERF2 REV3L 25348397 N/A physical interaction ComPPI
REV1 REV3L 14525934 15189446 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
REV3L PMS1 25348397 N/A physical interaction ComPPI
REV3L STK17B 25348397 N/A physical interaction ComPPI
RPL14 REV3L 25348397 N/A physical interaction ComPPI
H1-5 REV3L 24234451 30021884 physical association cross-linking study IntAct
H3-3A REV3L 24234451 30021884 physical association cross-linking study IntAct
H1-2 REV3L 24234451 30021884 physical association cross-linking study IntAct
H1-1 REV3L 24234451 30021884 physical association cross-linking study IntAct
SLTM REV3L 24234451 30021884 physical association cross-linking study IntAct
CHEK2 REV3L 18622427 27898060 N/A N/A OmniPath
PCNA REV3L 19806028 27898060 stimulant N/A OmniPath
TP53 REV3L 16980608 27898060 stimulant N/A OmniPath
REV1 REV3L 15189446 16546083 17030609 18953031 20164194 21926160 27898060 stimulant N/A OmniPath

Visualization










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