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GENE：SREBF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SREBF1
FullNmae sterol regulatory element binding transcription factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11289
EnsembleID ENSG00000072310
Uniprot P36956

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SREBF1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SREBF1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SREBF1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SREBF1 GO:0000122,GO:0000139,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000981,GO:0001221,GO:0001228,GO:0003062,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006357,GO:0006629,GO:0006695,GO:0007623,GO:0008286,GO:0008610,GO:0008610,GO:0009267,GO:0009410,GO:0009749,GO:0010867,GO:0010883,GO:0012507,GO:0019217,GO:0019901,GO:0030073,GO:0030324,GO:0030522,GO:0031647,GO:0032094,GO:0032526,GO:0032570,GO:0032810,GO:0032933,GO:0032933,GO:0033762,GO:0042789,GO:0045444,GO:0045471,GO:0045542,GO:0045542,GO:0045944,GO:0045944,GO:0045944,GO:0046676,GO:0046983,GO:0051591,GO:0071398,GO:0090209,GO:1902895,GO:1903146,GO:1903214,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SREBF1 hsa:6720 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
SREBF1 hsa:6720 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SREBF1 hsa:6720 path:hsa04931 Insulin resistance - Homo sapiens (human)
SREBF1 hsa:6720 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
SREBF1 hsa:6720 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK3 SREBF1 10627507 23180781 phosphorylation reaction protein kinase assay InnateDB
MAPK1 SREBF1 10627507 23180781 phosphorylation reaction protein kinase assay InnateDB
SREBF1 RELA 14527995 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G6 SREBF1 15450207 23180781 physical association electrophoretic mobility shift assay InnateDB
SREBF1 SREBF1 21157483 26467481 interaction type,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
ETS1 SREBF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SREBF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SREBF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SREBF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR SREBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SREBF1 15462672 20179320 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SREBF1 15462672 20179320 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SREBF1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA SREBF1 23622248 23951060 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 SREBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000CBE63 SREBF1 24300912 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000148B91 SREBF1 23951060 25416803 26701625 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00004AC389 SREBF1 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000031E12 SREBF1 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000075C3F6 SREBF1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SREBF1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D SREBF1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B7450 SREBF1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D SREBF1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF SREBF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F SREBF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED SREBF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003677B2 SREBF1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000475586 SREBF1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025EABA SREBF1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000021D08 SREBF1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA SREBF1 22135298 phosphorylation N/A PhosphoSite
MAPK3 SREBF1 22135298 phosphorylation N/A PhosphoSite
CDK1 SREBF1 22135298 phosphorylation N/A PhosphoSite
GSK3B SREBF1 22135298 phosphorylation N/A PhosphoSite
MAPK14 SREBF1 22135298 phosphorylation N/A PhosphoSite
MAPK1 SREBF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK8 SREBF1 22135298 phosphorylation N/A PhosphoSite
YY1 SREBF1 25361965 interaction type N/A PTMCode2
SREBF1 YY1 25361965 interaction type N/A PTMCode2
SREBF1 MAPK1 25361965 interaction type N/A PTMCode2
PPARGC1B SREBF1 25361965 interaction type N/A PTMCode2
SREBF1 PPARGC1B 25361965 interaction type N/A PTMCode2
FBXW7 SREBF1 25361965 interaction type N/A PTMCode2
SREBF1 FBXW7 25361965 interaction type N/A PTMCode2
SREBF1 LMNA 25361965 interaction type N/A PTMCode2
LMNA SREBF1 25361965 interaction type N/A PTMCode2
SREBF1 TWIST1 25361965 interaction type N/A PTMCode2
TWIST1 SREBF1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I SREBF1 12615929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LMNA SREBF1 11929849 19727227 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
ATXN1 SREBF1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MED21 SREBF1 25348397 N/A physical interaction ComPPI
HSP90AB1 SREBF1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
INSIG2 SREBF1 25348397 N/A physical interaction ComPPI
MAPK1 SREBF1 10915800 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SP1 SREBF1 10224053 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FBXW7 SREBF1 16054087 16825193 19126544 24298052 25348397 26759235 27898060 N/A physical interaction ComPPI,OmniPath
MAPK3 SREBF1 10915800 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR SREBF1 18245227 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CREBBP SREBF1 14525934 25348397 9651391 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD
SUMO1 SREBF1 12615929 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EP300 SREBF1 10235267 12640139 14615581 20534441 20817729 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GSK3B SREBF1 25348397 N/A physical interaction ComPPI
MED1 SREBF1 25348397 N/A pull down,pull down,physical interaction,physical interaction ComPPI
MED24 SREBF1 25348397 N/A physical interaction ComPPI
UBB SREBF1 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI
UBC SREBF1 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI
RPS27A SREBF1 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI
UBA52 SREBF1 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI
HSP90AA1 SREBF1 25348397 N/A physical interaction ComPPI
PLK1 SREBF1 25348397 N/A physical interaction ComPPI
PRMT5 SREBF1 25348397 N/A physical interaction ComPPI
SREBF1 YY1 10224053 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SREBF1 NR0B1 11713202 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SREBF1 ESR1 12021179 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SREBF1 ESR2 12021179 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SREBF1 SMARCD3 14525934 14701856 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SREBF1 KLF13 25348397 N/A physical interaction ComPPI
SREBF1 MED15 25348397 N/A anti tag coimmunoprecipitation,classical fluorescence spectroscopy,pull down,pull down,physical interaction,physical interaction ComPPI
SREBF1 MED23 25348397 N/A physical interaction ComPPI
SREBF1 MED13 25348397 N/A physical interaction ComPPI
SREBF1 MED12 25348397 N/A physical interaction ComPPI
SREBF1 MED14 25348397 N/A physical interaction ComPPI
SREBF1 MED26 25348397 N/A physical interaction ComPPI
SREBF1 MED6 25348397 N/A pull down,pull down,physical interaction,physical interaction ComPPI
SREBF1 HNF4A 25348397 N/A physical interaction ComPPI
SREBF1 TRRAP 25348397 N/A physical interaction ComPPI
SREBF1 KAT2A 25348397 N/A physical interaction ComPPI
SREBF1 ATM 25348397 N/A physical interaction ComPPI
SREBF1 GCN1 25348397 N/A physical interaction ComPPI
SREBF1 TADA2B 25348397 N/A physical interaction ComPPI
SREBF1 TADA3 25348397 N/A physical interaction ComPPI
SREBF1 RUVBL2 25348397 N/A physical interaction ComPPI
SREBF1 SIRT1 20595232 20817729 25348397 27898060 N/A pull down,physical interaction ComPPI,OmniPath
SREBF1 MED25 25348397 N/A physical interaction ComPPI
SREBF1 MED17 25348397 N/A physical interaction ComPPI
SREBF1 CDK8 25348397 N/A pull down,pull down,physical interaction,physical interaction ComPPI
SREBF1 USF1 19303849 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SREBF1 ZBTB7C 22331133 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SREBF1 SREBF2 25348397 N/A physical interaction ComPPI
SREBF1 SCAP 25348397 N/A physical interaction ComPPI
SREBF1 INSIG1 25348397 N/A physical interaction ComPPI
SREBF1 EGF 25348397 N/A physical interaction ComPPI
SREBF1 ATXN1L 25348397 N/A physical interaction ComPPI
SREBF1 HSP90AA2P 25348397 N/A physical interaction ComPPI
SREBF1 ERLIN2 25348397 N/A physical interaction ComPPI
SREBF1 KLF5 25348397 N/A physical interaction ComPPI
SREBF1 ID2 25348397 N/A physical interaction ComPPI
SREBF1 PVALB 25348397 N/A physical interaction ComPPI
SREBF1 SORL1 25348397 N/A physical interaction ComPPI
SREBF1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
SREBF1 TRIM25 25348397 N/A physical interaction ComPPI
SREBF1 POLR2A 25348397 N/A physical interaction ComPPI
SREBF1 TP53 25348397 N/A cross-linking study ComPPI
SREBF1 MEN1 24234451 25348397 25962847 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ID3 SREBF1 10585876 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TWIST2 SREBF1 14525934 14654692 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
ZBTB7A SREBF1 25348397 N/A physical interaction ComPPI
MED7 SREBF1 25348397 N/A physical interaction ComPPI
SREBF1 SREBF1 14525934 9634703 N/A experimental interaction detection HPRD
NCOR1 SREBF1 24234451 26120082 association chromatin immunoprecipitation assay IntAct
SREBF1 NR1H2 24234451 26120082 association chromatin immunoprecipitation assay IntAct
SREBF1 NR1H3 24234451 26120082 association chromatin immunoprecipitation assay IntAct
SREBF1 RNF20 24425205 27898060 N/A N/A OmniPath
PLA2G6 SREBF1 15450207 27898060 N/A N/A OmniPath
PRKAA2 SREBF1 21459323 27898060 inhibition N/A OmniPath
PRKACA SREBF1 16381800 27898060 inhibition N/A OmniPath
MAPK3 SREBF1 10627507 10915800 18669648 27898060 stimulant N/A OmniPath
MAPK14 SREBF1 22384276 27898060 N/A N/A OmniPath
CDK1 SREBF1 16880739 27898060 stimulant N/A OmniPath
SUMO1 SREBF1 12615929 27898060 N/A N/A OmniPath
SP1 SREBF1 10224053 10235267 18068676 27898060 stimulant N/A OmniPath
MAPK1 SREBF1 10627507 10915800 18669648 20863500 25353341 27898060 stimulant N/A OmniPath
SREBF1 PPARG 21157483 27898060 stimulant N/A OmniPath
GSK3B SREBF1 16825193 19126544 27898060 inhibition N/A OmniPath
RPS6KB1 SREBF1 20670887 27898060 stimulant N/A OmniPath
PRKAA1 SREBF1 21459323 21892142 27898060 inhibition N/A OmniPath

Visualization










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