GENE：ST8SIA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ST8SIA4 |
| FullNmae | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10871 |
| EnsembleID | ENSG00000113532 |
| Uniprot | Q92187 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ST8SIA4 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ST8SIA4 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ST8SIA4 | GO:0000139,GO:0001574,GO:0003828,GO:0003828,GO:0003828,GO:0006486,GO:0006486,GO:0006491,GO:0006491,GO:0007399,GO:0009311,GO:0009311,GO:0033691,GO:0036211 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ST8SIA4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | ST8SIA4 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | ST8SIA4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ST8SIA4 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ST8SIA4 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ST8SIA4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ST8SIA4 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | ST8SIA4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ST8SIA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | ST8SIA4 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000076B539 | ST8SIA4 | 21572407 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006B702 | ST8SIA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015B295 | ST8SIA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FD1B | ST8SIA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003003B4 | ST8SIA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | ST8SIA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | ST8SIA4 | 25416803 28032858 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000018C928 | ST8SIA4 | 25416803 27527856 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGB5 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| TUFM | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA7 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| SEMA4D | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| ITGAV | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| TUBA4A | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| RUFY1 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| RNASEL | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| LNPEP | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| EPHB4 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM17 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR3 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA4 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| TMBIM6 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| STK39 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| BCAM | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| FAT1 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| NCAM1 | ST8SIA4 | 14525934 25348397 9774483 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTGFRN | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | BACE2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | PRKD2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | NLGN2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | HLA-C | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | TUBB3 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | ITGA8 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | CELSR2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | ACTA2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | PON2 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | TMEM132A | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | LRP6 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | NCAM1 | 17623646 27898060 9774483 | N/A | N/A | OmniPath |