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GENE：ATG4B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG4B
FullNmae autophagy related 4B cysteine peptidase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20790
EnsembleID ENSG00000168397
Uniprot Q9Y4P1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG4B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG4B autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATG4B GO:0000045,GO:0000421,GO:0000423,GO:0004175,GO:0004197,GO:0004197,GO:0005515,GO:0005739,GO:0005783,GO:0005829,GO:0006508,GO:0006914,GO:0008234,GO:0015031,GO:0016236,GO:0016237,GO:0019786,GO:0031173,GO:0031410,GO:0034497,GO:0051697,GO:0061912,GO:0097110

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG4B hsa:23192 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG4B hsa:23192 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP1LC3B ATG4B 15355958 19549685 23180781 cleavage reaction,protein cleavage protease assay InnateDB
MAP1LC3A ATG4B 15187094 23180781 protein cleavage protease assay InnateDB
GABARAP ATG4B 15187094 23180781 protein cleavage protease assay InnateDB
GABARAPL2 ATG4B 15187094 19549685 23180781 cleavage reaction,protein cleavage protease assay InnateDB
GABARAPL1 ATG4B 19549685 23180781 cleavage reaction protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATG4B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATG4B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A ATG4B 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA ATG4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATG4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATG4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATG4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 ATG4B 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EED18 ATG4B 25416803 26313360 26499184 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ATG3 ATG4B 25361965 interaction type N/A PTMCode2
ATG4B ATG3 25361965 interaction type N/A PTMCode2
GABARAPL1 ATG4B 25361965 interaction type N/A PTMCode2
ATG4B GABARAPL1 25361965 interaction type N/A PTMCode2
GABARAPL2 ATG4B 25361965 interaction type N/A PTMCode2
ATG4B GABARAPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
STK16 ATG4B 25348397 N/A physical interaction ComPPI
KRT4 ATG4B 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BAG3 ATG4B 25348397 N/A physical interaction ComPPI
ANXA1 ATG4B 25348397 N/A physical interaction ComPPI
GABARAPL2 ATG4B 14525934 16169070 17353931 20562859 21900206 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
MAP1LC3B ATG4B 14525934 16169070 18083104 19322194 20010802 20562859 21900206 24234451 25348397 cleavage reaction,association,physical association anti tag coimmunoprecipitation,two hybrid,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,protease assay,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
YWHAB ATG4B 25348397 N/A physical interaction ComPPI
SQSTM1 ATG4B 25348397 N/A physical interaction ComPPI
GABARAP ATG4B 14525934 16169070 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAP1LC3A ATG4B 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STK3 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW11 ATG4B 25348397 N/A physical interaction ComPPI
CAMKK2 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG3 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TES ATG4B 25348397 N/A physical interaction ComPPI
SHMT2 ATG4B 25348397 N/A physical interaction ComPPI
ATG12 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG10 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAPL1 ATG4B 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATG4B AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG4B MOV10 25348397 N/A physical interaction ComPPI
ATG4B NXF1 25348397 N/A physical interaction ComPPI
ATG4B FANK1 25348397 N/A physical interaction ComPPI
ATG4B SLX4IP 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG4B SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG4B MAP1LC3C 20562859 24234451 25348397 physical association pull down,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATG4B KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG4B ATG4B 20562859 24234451 association anti tag coimmunoprecipitation IntAct
ATG4B GABARAP 14530254 15187094 16169070 20562859 25126726 27898060 inhibition,stimulant N/A OmniPath
ATG4B MAP1LC3B 11038174 14530254 15187094 15355958 16169070 19322194 19549685 20010802 20562859 21900206 24023838 27898060 inhibition,stimulant N/A OmniPath
ATG4B GABARAPL1 14530254 16704426 19549685 20404487 20562859 27898060 inhibition,stimulant N/A OmniPath
ATG4B GABARAPL2 14530254 15187094 16169070 17353931 19549685 20562859 21900206 27898060 stimulant N/A OmniPath
ATG4B MAP1LC3C 15187094 20562859 27898060 stimulant N/A OmniPath

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