Gene Information gene info

  1. Home

GENE：HAX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HAX1
FullNmae HCLS1 associated protein X-1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16915
EnsembleID ENSG00000143575
Uniprot O00165

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HAX1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HAX1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HAX1 GO:0000932,GO:0005515,GO:0005635,GO:0005667,GO:0005739,GO:0005739,GO:0005741,GO:0005758,GO:0005759,GO:0005783,GO:0005938,GO:0015629,GO:0015629,GO:0016324,GO:0016529,GO:0019966,GO:0030027,GO:0030136,GO:0030833,GO:0030833,GO:0030854,GO:0031965,GO:0033138,GO:0042981,GO:0043066,GO:0043066,GO:0045944,GO:0050731,GO:0051897,GO:0071345,GO:0110053,GO:1903146,GO:1903214

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HTRA2 HAX1 11803371 15371414 23070005 26192618 interaction type N/A ACSN
IL1A HAX1 11554782 23180781 physical association anti tag coimmunoprecipitation,two hybrid,far western blotting InnateDB
EGR1 HAX1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 HAX1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA HAX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HAX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HAX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HAX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 HAX1 19679660 trascriptional regulation,stimulation inferred by curator TFlink
MYC HAX1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 HAX1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001597DC HAX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017DBB8 HAX1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 HAX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 HAX1 25416803 27880721 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000B7E30 HAX1 25416803 27618431 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HCLS1 HAX1 25361965 interaction type N/A PTMCode2
HAX1 HCLS1 25361965 interaction type N/A PTMCode2
CTTN HAX1 25361965 interaction type N/A PTMCode2
HAX1 CTTN 25361965 interaction type N/A PTMCode2
PKD2 HAX1 25361965 interaction type N/A PTMCode2
HAX1 PKD2 25361965 interaction type N/A PTMCode2
KIAA0513 HAX1 25361965 interaction type N/A PTMCode2
HAX1 KIAA0513 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RAB14 HAX1 25348397 N/A physical interaction ComPPI
CTDSP2 HAX1 25348397 N/A physical interaction ComPPI
ATP5F1B HAX1 25348397 N/A physical interaction ComPPI
RAB3A HAX1 25348397 N/A physical interaction ComPPI
HPCAL1 HAX1 25348397 N/A physical interaction ComPPI
PRKAR2B HAX1 25348397 N/A physical interaction ComPPI
NCALD HAX1 25348397 N/A physical interaction ComPPI
XIAP HAX1 20171186 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KEAP1 HAX1 25348397 N/A physical interaction ComPPI
HSP90AB1 HAX1 25348397 N/A physical interaction ComPPI
SCAMP1 HAX1 25348397 N/A physical interaction ComPPI
DPYSL4 HAX1 25348397 N/A physical interaction ComPPI
VSNL1 HAX1 25348397 N/A physical interaction ComPPI
DCP1A HAX1 23164465 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
GRB7 HAX1 20665473 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
PTPN18 HAX1 25348397 N/A physical interaction ComPPI
HCLS1 HAX1 14525934 25348397 9058808 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SHC1 HAX1 25348397 N/A physical interaction ComPPI
PTPN22 HAX1 25348397 N/A physical interaction ComPPI
GSK3B HAX1 25348397 N/A physical interaction ComPPI
RBX1 HAX1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CUL3 HAX1 25348397 N/A physical interaction ComPPI
CLU HAX1 25348397 N/A physical interaction ComPPI
SYN1 HAX1 25348397 N/A physical interaction ComPPI
GNAQ HAX1 25348397 N/A physical interaction ComPPI
UBC HAX1 25348397 N/A physical interaction ComPPI
NTRK1 HAX1 25348397 N/A physical interaction ComPPI
SNAP91 HAX1 25348397 N/A physical interaction ComPPI
HIPK1 HAX1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ILK HAX1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APOD HAX1 25348397 N/A physical interaction ComPPI
PKD2 HAX1 10760273 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
HAX1 EIF3F 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HAX1 ABCB11 14525934 15159385 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
HAX1 ABCB4 14525934 15159385 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
HAX1 CTTN 14525934 15159385 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HAX1 DGKD 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HAX1 KIAA0513 14525934 17010949 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HAX1 SVIL 14525934 20309963 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HAX1 IL1A 11554782 14525934 16971486 24234451 25348397 25416956 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,lambda repressor two hybrid ComPPI,HPRD,IntAct
HAX1 ABCC4 25348397 N/A physical interaction ComPPI
HAX1 RGS1 25348397 N/A physical interaction ComPPI
HAX1 HSPA5 25348397 N/A physical interaction ComPPI
HAX1 TUBB4A 25348397 N/A physical interaction ComPPI
HAX1 MATN4 25348397 N/A physical interaction ComPPI
HAX1 AKAP10 25348397 N/A physical interaction ComPPI
HAX1 EIF3D 25348397 N/A physical interaction ComPPI
HAX1 HNF4G 25348397 N/A physical interaction ComPPI
HAX1 AMFR 25348397 N/A physical interaction ComPPI
HAX1 PIDD1 25348397 N/A physical interaction ComPPI
HAX1 CUL4A 25348397 N/A physical interaction ComPPI
HAX1 HTRA2 25348397 N/A physical interaction ComPPI
HAX1 EWSR1 25348397 N/A physical interaction ComPPI
HAX1 CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HAX1 POLR1H 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HAX1 PPP3CC 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HAX1 MAPK10 21988832 23602568 24234451 25348397 association,physical association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
HAX1 STAT5B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HAX1 POLR1D 25348397 N/A physical interaction ComPPI
HAX1 POLR1D 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HAX1 ZNF420 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HAX1 DYRK4 25348397 N/A physical interaction ComPPI
HAX1 CEP250 25348397 N/A physical interaction ComPPI
HAX1 TUBGCP2 25348397 N/A physical interaction ComPPI
HAX1 TUBGCP3 25348397 N/A physical interaction ComPPI
HAX1 BIRC3 25348397 N/A physical interaction ComPPI
HAX1 ERLIN2 21343306 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HAX1 ABCE1 25348397 N/A physical interaction ComPPI
HAX1 GPM6A 25348397 N/A physical interaction ComPPI
HAX1 STXBP1 25348397 N/A physical interaction ComPPI
HAX1 ATP4A 25348397 N/A physical interaction ComPPI
HAX1 HPCA 25348397 N/A physical interaction ComPPI
HAX1 CAMK2B 25348397 N/A physical interaction ComPPI
HAX1 CAMK2A 25348397 N/A physical interaction ComPPI
HAX1 GPM6B 25348397 N/A physical interaction ComPPI
HAX1 H2BC13 25348397 N/A physical interaction ComPPI
HAX1 DCX 25348397 N/A physical interaction ComPPI
HAX1 DCLK1 25348397 N/A physical interaction ComPPI
HAX1 NCAM1 25348397 N/A physical interaction ComPPI
HAX1 SYT1 25348397 N/A physical interaction ComPPI
HAX1 SYN2 25348397 N/A physical interaction ComPPI
HAX1 CRMP1 25348397 N/A physical interaction ComPPI
HAX1 DPYSL3 25348397 N/A physical interaction ComPPI
HAX1 DPYSL2 25348397 N/A physical interaction ComPPI
HAX1 DNM1 25348397 N/A physical interaction ComPPI
HAX1 EPB41L1 25348397 N/A physical interaction ComPPI
HAX1 DNM1L 25348397 N/A physical interaction ComPPI
HAX1 GPD2 25348397 N/A physical interaction ComPPI
HAX1 GNAO1 25348397 N/A physical interaction ComPPI
HAX1 GNG2 25348397 N/A physical interaction ComPPI
HAX1 ANK2 25348397 N/A physical interaction ComPPI
HAX1 SNCA 25348397 N/A physical interaction ComPPI
HAX1 CALB2 25348397 N/A physical interaction ComPPI
HAX1 RAB6B 25348397 N/A physical interaction ComPPI
HAX1 RAB6A 25348397 N/A physical interaction ComPPI
HAX1 GRIA2 25348397 N/A physical interaction ComPPI
HAX1 RAB5A 25348397 N/A physical interaction ComPPI
HAX1 CNTN1 25348397 N/A physical interaction ComPPI
HAX1 STX1A 25348397 N/A physical interaction ComPPI
HAX1 STX1B 25348397 N/A physical interaction ComPPI
HAX1 CDH13 25348397 N/A physical interaction ComPPI
HAX1 LASP1 25348397 N/A physical interaction ComPPI
HAX1 AMPH 25348397 N/A physical interaction ComPPI
HAX1 NDRG4 25348397 N/A physical interaction ComPPI
HAX1 NTM 25348397 N/A physical interaction ComPPI
HAX1 NAPB 25348397 N/A physical interaction ComPPI
HAX1 MAPT 25348397 N/A physical interaction ComPPI
HAX1 MAP2 25348397 N/A physical interaction ComPPI
HAX1 RAB2A 25348397 N/A physical interaction ComPPI
HAX1 CAMKV 25348397 N/A physical interaction ComPPI
HAX1 SYP 25348397 N/A physical interaction ComPPI
HAX1 EDIL3 25348397 N/A physical interaction ComPPI
HAX1 DPP6 25348397 N/A physical interaction ComPPI
HAX1 L1CAM 25348397 N/A physical interaction ComPPI
HAX1 XPO1 23164465 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HAX1 XRCC3 25348397 N/A physical interaction ComPPI
HAX1 SLC33A1 25348397 N/A physical interaction ComPPI
HAX1 DNAJC11 25348397 N/A physical interaction ComPPI
HAX1 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HAX1 RNF217 25298122 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HAX1 CTDNEP1 25348397 N/A physical interaction ComPPI
HAX1 PPEF2 25348397 N/A physical interaction ComPPI
HAX1 CDKN3 25348397 N/A physical interaction ComPPI
HAX1 CDK20 25348397 N/A physical interaction ComPPI
HAX1 H1-5 25348397 N/A physical interaction ComPPI
HAX1 MAPRE3 25348397 N/A physical interaction ComPPI
HAX1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HAX1 TNK2 25348397 N/A physical interaction ComPPI
HAX1 TES 25348397 N/A physical interaction ComPPI
HAX1 BECN1 25348397 N/A physical interaction ComPPI
HAX1 MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HAX1 RELA 25348397 N/A tandem affinity purification ComPPI
HAX1 TNFRSF1A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HAX1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HAX1 TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HAX1 ESR1 21217774 24234451 25348397 physical association two hybrid,phage display ComPPI,IntAct
HAX1 TPCN2 24188827 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
HAX1 TPCN1 24188827 24234451 25348397 physical association two hybrid,pull down ComPPI,IntAct
HAX1 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
HAX1 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HAX1 PSMD2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HAX1 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
HAX1 IFT27 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
HAX1 TUBA1A 24234451 25348397 27291054 29568061 association pull down ComPPI,IntAct
HAX1 PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
HAX1 DUSP16 24234451 25348397 28330616 association pull down ComPPI,IntAct
HAX1 SAV1 21567072 22570112 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,confocal microscopy ComPPI,IntAct
HAX1 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
HAX1 AIFM1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
HAX1 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HAX1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HAX1 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HAX1 LAMP1 24234451 25348397 29568061 association pull down ComPPI,IntAct
RPA1 HAX1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK6 HAX1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAQ HAX1 14525934 25348397 9058808 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
NEDD4L HAX1 25348397 N/A physical interaction ComPPI
DPYSL5 HAX1 25348397 N/A physical interaction ComPPI
HSPA9 HAX1 25348397 N/A physical interaction ComPPI
COX4I1 HAX1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT HAX1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PELO HAX1 20406461 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,fluorescence microscopy,bimolecular fluorescence complementation ComPPI,IntAct
HAX1 ABCB1 14525934 15159385 N/A experimental interaction detection,two hybrid HPRD
MKI67 HAX1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
TANK HAX1 24234451 30561431 association virotrap IntAct
GZMB HAX1 20388708 27898060 inhibition N/A OmniPath
IL1A HAX1 11554782 25416956 27898060 N/A N/A OmniPath

Visualization










  Return