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GENE：ACTL6A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACTL6A
FullNmae actin like 6A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24124
EnsembleID ENSG00000136518
Uniprot O96019

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACTL6A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACTL6A GO:0000723,GO:0000776,GO:0000785,GO:0000785,GO:0000786,GO:0000786,GO:0001825,GO:0003407,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0006275,GO:0006281,GO:0006282,GO:0006310,GO:0006338,GO:0006338,GO:0006338,GO:0006338,GO:0006355,GO:0006357,GO:0006357,GO:0007165,GO:0007399,GO:0008284,GO:0016363,GO:0016514,GO:0016514,GO:0016514,GO:0016586,GO:0021510,GO:0030071,GO:0031011,GO:0031492,GO:0032991,GO:0033044,GO:0035060,GO:0035267,GO:0035267,GO:0042981,GO:0043967,GO:0045582,GO:0045596,GO:0045597,GO:0045663,GO:0045739,GO:0045893,GO:0045893,GO:0045995,GO:0051726,GO:0060382,GO:0070316,GO:0071564,GO:0071564,GO:0071564,GO:0140288,GO:1902459,GO:1904507,GO:1905168,GO:2000045,GO:2000779,GO:2000781,GO:2000819

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACTL6A hsa:86 path:hsa03082 ATP-dependent chromatin remodeling - Homo sapiens (human)
ACTL6A hsa:86 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACTL6A hsa:86 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KAT5 ACTL6A 14966270 23180781 physical association tandem affinity purification InnateDB
ACTL6A DMAP1 14966270 23180781 physical association tandem affinity purification InnateDB
MORF4L1 ACTL6A 14966270 23180781 physical association tandem affinity purification InnateDB
ING3 ACTL6A 14966270 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACTL6A UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ACTL6A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ACTL6A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ACTL6A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACTL6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E ACTL6A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000C85B2 ACTL6A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 ACTL6A 23728344 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SMARCD1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCD1 25361965 interaction type N/A PTMCode2
MYC ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A MYC 25361965 interaction type N/A PTMCode2
ING2 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A ING2 25361965 interaction type N/A PTMCode2
SMARCD2 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCD2 25361965 interaction type N/A PTMCode2
BRD8 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A BRD8 25361965 interaction type N/A PTMCode2
BANF1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A BANF1 25361965 interaction type N/A PTMCode2
SMARCA4 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCA4 25361965 interaction type N/A PTMCode2
MRGBP ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A MRGBP 25361965 interaction type N/A PTMCode2
SMARCA2 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCA2 25361965 interaction type N/A PTMCode2
FLII ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A FLII 25361965 interaction type N/A PTMCode2
EP400 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A EP400 25361965 interaction type N/A PTMCode2
SMARCC1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCC1 25361965 interaction type N/A PTMCode2
SMARCE1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCE1 25361965 interaction type N/A PTMCode2
SMARCB1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCB1 25361965 interaction type N/A PTMCode2
DMAP1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A DMAP1 25361965 interaction type N/A PTMCode2
ZNHIT1 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A ZNHIT1 25361965 interaction type N/A PTMCode2
TRRAP ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A TRRAP 25361965 interaction type N/A PTMCode2
SMARCC2 ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A SMARCC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 ACTL6A 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MORF4L2 ACTL6A 12963728 15647280 24234451 25348397 association,physical association affinity chromatography technology,molecular sieving,physical interaction ComPPI,IntAct
SMARCE1 ACTL6A 11780067 24234451 25348397 physical association physical interaction,ion exchange chromatography ComPPI,IntAct
CDC5L ACTL6A 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TFPT ACTL6A 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB14 ACTL6A 25348397 N/A physical interaction ComPPI
SMARCC1 ACTL6A 11780067 24234451 24421395 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,ion exchange chromatography ComPPI,IntAct
ZNHIT1 ACTL6A 15647280 16230350 24234451 25348397 association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRGBP ACTL6A 12963728 14525934 15647280 16230350 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vitro ComPPI,HPRD,IntAct
BMI1 ACTL6A 25348397 N/A physical interaction ComPPI
INO80B ACTL6A 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NFATC1 ACTL6A 25348397 N/A physical interaction ComPPI
GRB2 ACTL6A 25348397 N/A physical interaction ComPPI
JUN ACTL6A 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMARCD1 ACTL6A 11780067 24234451 25348397 physical association physical interaction,ion exchange chromatography ComPPI,IntAct
ARHGDIA ACTL6A 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CUL3 ACTL6A 25348397 N/A physical interaction ComPPI
UBC ACTL6A 25348397 N/A physical interaction ComPPI
NTRK1 ACTL6A 25348397 N/A physical interaction ComPPI
USO1 ACTL6A 25348397 N/A physical interaction ComPPI
RUVBL1 ACTL6A 11839798 12963728 14525934 15647280 16230350 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vivo ComPPI,HPRD,IntAct
SMARCA4 ACTL6A 11780067 15985610 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,ion exchange chromatography,in vivo ComPPI,IntAct
FEN1 ACTL6A 25348397 N/A physical interaction ComPPI
ING1 ACTL6A 25348397 N/A physical interaction ComPPI
METAP2 ACTL6A 25348397 N/A physical interaction ComPPI
MYC ACTL6A 11839798 14525934 17314511 24234451 25348397 25609649 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
HDLBP ACTL6A 25348397 N/A physical interaction ComPPI
MAP2K2 ACTL6A 25348397 N/A physical interaction ComPPI
ARID1B ACTL6A 25348397 N/A physical interaction ComPPI
NFATC2 ACTL6A 25348397 N/A physical interaction ComPPI
EWSR1 ACTL6A 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RELA ACTL6A 14525934 14743216 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMARCB1 ACTL6A 11780067 24234451 25348397 30108113 association,physical association pull down,physical interaction,ion exchange chromatography,proximity-dependent biotin identification ComPPI,IntAct
MORF4L1 ACTL6A 12963728 15647280 24234451 25348397 association,physical association affinity chromatography technology,molecular sieving,physical interaction ComPPI,IntAct
BRD8 ACTL6A 12963728 15647280 24234451 25348397 association,physical association affinity chromatography technology,molecular sieving ComPPI,IntAct
ZRANB2 ACTL6A 25348397 N/A physical interaction ComPPI
TSFM ACTL6A 25348397 N/A physical interaction ComPPI
CDK2 ACTL6A 25348397 N/A physical interaction ComPPI
YY1 ACTL6A 18026119 24234451 25348397 27705803 association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
SOX2 ACTL6A 25348397 N/A physical interaction ComPPI
CBX5 ACTL6A 20562864 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC2 ACTL6A 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCP1 ACTL6A 25348397 N/A physical interaction ComPPI
CCT7 ACTL6A 25348397 N/A physical interaction ComPPI
MCRS1 ACTL6A 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BANF1 ACTL6A 25348397 N/A physical interaction ComPPI
SF3A1 ACTL6A 25348397 N/A physical interaction ComPPI
YAP1 ACTL6A 25348397 N/A physical interaction ComPPI
TRRAP ACTL6A 11839798 12963728 14525934 15647280 24234451 25348397 association,physical association affinity chromatography technology,experimental interaction detection,molecular sieving,physical interaction,in vivo ComPPI,HPRD,IntAct
POLR2A ACTL6A 14525934 25348397 9710619 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ACTL6A FLII 14525934 14966289 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACTL6A RELB 25348397 N/A physical interaction,physical interaction,tandem affinity purification,tandem affinity purification ComPPI
ACTL6A EP400 12963728 15647280 24234451 25348397 association,physical association affinity chromatography technology,molecular sieving,physical interaction ComPPI,IntAct
ACTL6A SMARCA2 12437990 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ACTL6A KAT2A 25348397 N/A physical interaction ComPPI
ACTL6A KAT5 10966108 15647280 24234451 25348397 association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A ING2 25348397 N/A physical interaction ComPPI
ACTL6A ING3 15647280 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
ACTL6A RUVBL2 12963728 15647280 16230350 18026119 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,cosedimentation through density gradient,molecular sieving,physical interaction ComPPI,IntAct
ACTL6A BCL7C 25348397 N/A physical interaction ComPPI
ACTL6A INO80 16230350 18026119 24234451 25348397 association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
ACTL6A INO80E 16230350 18922472 21303910 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A H2AZ1 25348397 N/A physical interaction ComPPI
ACTL6A ACTR5 16230350 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A ACTR8 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A INO80C 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A INO80D 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A NFRKB 16230350 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A DMAP1 12963728 15647280 24234451 25348397 association,physical association affinity chromatography technology,molecular sieving,physical interaction ComPPI,IntAct
ACTL6A PBRM1 11780067 24234451 25348397 physical association physical interaction,ion exchange chromatography ComPPI,IntAct
ACTL6A SMARCAD1 25348397 N/A physical interaction ComPPI
ACTL6A HDGF 25348397 N/A physical interaction ComPPI
ACTL6A SMARCC2 11780067 24234451 25348397 physical association physical interaction,ion exchange chromatography ComPPI,IntAct
ACTL6A TP53 25348397 N/A physical interaction ComPPI
ACTL6A CDK9 25348397 N/A physical interaction ComPPI
ACTL6A CAND1 25348397 N/A physical interaction ComPPI
ACTL6A UCHL5 18922472 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A ARID1A 25348397 N/A physical interaction ComPPI
ACTL6A FBXO6 25348397 N/A physical interaction ComPPI
ACTL6A HECW2 25348397 N/A physical interaction ComPPI
ACTL6A SHMT2 25348397 N/A physical interaction ComPPI
ACTL6A MOV10 25348397 N/A physical interaction ComPPI
ACTL6A NXF1 25348397 N/A physical interaction ComPPI
ACTL6A DPF3 25348397 N/A physical interaction ComPPI
ACTL6A DPF2 25348397 N/A physical interaction ComPPI
ACTL6A CYB5R3 25348397 N/A physical interaction ComPPI
ACTL6A RAB1C 25348397 N/A physical interaction ComPPI
ACTL6A RAB1B 25348397 N/A physical interaction ComPPI
ACTL6A PDCL 25348397 N/A physical interaction ComPPI
ACTL6A SF1 25348397 N/A physical interaction ComPPI
ACTL6A ETF1 25348397 N/A physical interaction ComPPI
ACTL6A RPRD1B 25348397 N/A physical interaction ComPPI
ACTL6A MTDH 25348397 N/A physical interaction ComPPI
ACTL6A RIC8B 25348397 N/A physical interaction ComPPI
ACTL6A DDRGK1 25348397 N/A physical interaction ComPPI
ACTL6A CCT3 25348397 N/A physical interaction ComPPI
ACTL6A HDGFL2 25348397 N/A physical interaction ComPPI
ACTL6A CCT6B 25348397 N/A physical interaction ComPPI
ACTL6A CCT6A 25348397 N/A physical interaction ComPPI
ACTL6A CCT2 25348397 N/A physical interaction ComPPI
ACTL6A HINT1 25348397 N/A physical interaction ComPPI
ACTL6A CCT4 25348397 N/A physical interaction ComPPI
ACTL6A SS18 25348397 N/A physical interaction ComPPI
ACTL6A H2BC1 25348397 N/A physical interaction ComPPI
ACTL6A SMARCD2 11780067 24234451 25348397 physical association physical interaction,ion exchange chromatography ComPPI,IntAct
ACTL6A SMARCD3 18765789 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTL6A YEATS4 15647280 24234451 25348397 26496610 association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A KIF7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A TCF4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTL6A FOXN1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTL6A FOXR1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTL6A EPC1 15647280 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
ACTL6A MBTD1 25348397 N/A physical interaction ComPPI
ACTL6A BCL7A 25348397 N/A physical interaction ComPPI
ACTL6A NCL 25348397 N/A physical interaction ComPPI
ACTL6A DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTL6A MAX 25348397 N/A physical interaction ComPPI
ACTL6A MYCL 25348397 N/A physical interaction ComPPI
ACTL6A VPS72 15647280 24234451 25348397 association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTL6A MAP3K8 25348397 N/A tandem affinity purification ComPPI
ACTL6A ACTR6 15647280 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ACTL6A SRCAP 15647280 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ACTL6A MEAF6 15647280 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ACTL6A EPC2 15647280 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ACTL6A TRIM33 20603019 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTL6A FOXO6 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
ACTL6A KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 ACTL6A 25348397 N/A physical interaction ComPPI
TBL1XR1 ACTL6A 25348397 N/A physical interaction ComPPI
ACTL6A ATM 16141325 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BACE4 ACTL6A 27087310 direct interaction,inhibition N/A NPInter

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