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GENE：CYP21A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CYP21A2
FullNmae cytochrome P450 family 21 subfamily A member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2600
EnsembleID ENSG00000231852
Uniprot P08686

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CYP21A2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CYP21A2 GO:0004509,GO:0004509,GO:0005496,GO:0005506,GO:0005789,GO:0006694,GO:0006704,GO:0006704,GO:0006705,GO:0008202,GO:0008395,GO:0016125,GO:0020037,GO:0020037,GO:0103069,GO:0106309

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CYP21A2 hsa:1589 path:hsa00140 Steroid hormone biosynthesis - Homo sapiens (human)
CYP21A2 hsa:1589 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CYP21A2 hsa:1589 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
CYP21A2 hsa:1589 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
CYP21A2 hsa:1589 path:hsa04934 Cushing syndrome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR2C2 CYP21A2 11478808 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
CEBPA CYP21A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 CYP21A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CYP21A2 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
HSPD1 CYP21A2 24234451 30021884 physical association cross-linking study IntAct
EEF1D CYP21A2 24234451 30021884 physical association cross-linking study IntAct

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