GENE:PIK3R2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PIK3R2 |
FullNmae | phosphoinositide-3-kinase regulatory subunit 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:8980 |
EnsembleID | ENSG00000105647 |
Uniprot | O00459 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PIK3R2 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PIK3R2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PIK3R2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PIK3R2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PIK3R2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
PIK3R2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PIK3R2 | GO:0001678,GO:0001784,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0005942,GO:0005943,GO:0005943,GO:0006955,GO:0008286,GO:0010506,GO:0015031,GO:0019903,GO:0030183,GO:0030217,GO:0030833,GO:0030971,GO:0032869,GO:0034976,GO:0036312,GO:0042307,GO:0043409,GO:0043491,GO:0043551,GO:0045785,GO:0045944,GO:0046854,GO:0046935,GO:0046982,GO:0051492,GO:1903076 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
PIK3R2 | hsa:5296 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04931 | Insulin resistance - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05020 | Prion disease - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05162 | Measles - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05164 | Influenza A - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05214 | Glioma - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05218 | Melanoma - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
PIK3R2 | hsa:5296 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PIK3R2 | PIK3CD | 23180781 9113989 | physical association | gst pull down | InnateDB |
PIK3R2 | PIK3CA | 12147247 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
PIK3R2 | AXL | 23180781 9178760 | physical association | anti tag coimmunoprecipitation,far western blotting | InnateDB |
TRIM23 | PIK3R2 | 23180781 25416956 | physical association | two hybrid | InnateDB |
EPHA2 | PIK3R2 | 23331499 7982920 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GRB2 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
IRS1 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
IRS2 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
SHC1 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
SOCS1 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
SOCS6 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
SOCS7 | PIK3R2 | 20005715 | interaction type | N/A | PSP |
YWHAB | PIK3R2 | 20005715 | interaction type | N/A | PSP |
SOCS1 | PIK3R2 | 20005715 20005715 | N/A | N/A | SignaLink |
YWHAB | PIK3R2 | 15324660 18988627 20005715 20005715 | N/A | N/A | SignaLink |
IRS1 | PIK3R2 | 20005715 20005715 | N/A | N/A | SignaLink |
IRS2 | PIK3R2 | 10594015 18988627 20005715 20005715 9651378 | N/A | N/A | SignaLink |
SHC1 | PIK3R2 | 20005715 20005715 | N/A | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ETS1 | PIK3R2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA1 | PIK3R2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | PIK3R2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | PIK3R2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00001D69F6 | PIK3R2 | 18663744 18987025 21249429 | rna interference,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | miRSponge |
URS00001D69F6 | PIK3R2 | 18663744 18987025 21249429 24969300 25416803 26381870 27191494 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
URS00001C3AC1 | PIK3R2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00000DDD35 | PIK3R2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS000005CF5F | PIK3R2 | 25416803 27165190 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
URS0000065D58 | PIK3R2 | 25416803 27895663 | mrna cleavage,inhibition | western blot | TarBase |
URS00003380CC | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000008A99 | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS00004A9320 | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000221168 | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS00005CC20C | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000075C4B1 | PIK3R2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PIK3R2 | CSF1R | 25361965 | interaction type | N/A | PTMCode2 |
CSF1R | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | GAB1 | 25361965 | interaction type | N/A | PTMCode2 |
GAB1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
PIK3CA | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | CBL | 25361965 | interaction type | N/A | PTMCode2 |
CBL | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | CBLB | 25361965 | interaction type | N/A | PTMCode2 |
CBLB | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | EGF | 25361965 | interaction type | N/A | PTMCode2 |
EGF | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | IGF1R | 25361965 | interaction type | N/A | PTMCode2 |
IGF1R | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | ERBB2 | 25361965 | interaction type | N/A | PTMCode2 |
ERBB2 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
EGFR | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | KIT | 25361965 | interaction type | N/A | PTMCode2 |
KIT | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | MERTK | 25361965 | interaction type | N/A | PTMCode2 |
MERTK | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | INPPL1 | 25361965 | interaction type | N/A | PTMCode2 |
INPPL1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | CRK | 25361965 | interaction type | N/A | PTMCode2 |
CRK | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | AXL | 25361965 | interaction type | N/A | PTMCode2 |
AXL | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | GAB2 | 25361965 | interaction type | N/A | PTMCode2 |
GAB2 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | INSR | 25361965 | interaction type | N/A | PTMCode2 |
INSR | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | IRS1 | 25361965 | interaction type | N/A | PTMCode2 |
IRS1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | KHDRBS1 | 25361965 | interaction type | N/A | PTMCode2 |
KHDRBS1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | CD28 | 25361965 | interaction type | N/A | PTMCode2 |
CD28 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
GRB2 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | ERBB4 | 25361965 | interaction type | N/A | PTMCode2 |
ERBB4 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | CRKL | 25361965 | interaction type | N/A | PTMCode2 |
CRKL | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | PIK3CG | 25361965 | interaction type | N/A | PTMCode2 |
PIK3CG | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
FYN | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | SEMG2 | 25361965 | interaction type | N/A | PTMCode2 |
SEMG2 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | SEMG1 | 25361965 | interaction type | N/A | PTMCode2 |
SEMG1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | SYK | 25361965 | interaction type | N/A | PTMCode2 |
SYK | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | HCK | 25361965 | interaction type | N/A | PTMCode2 |
HCK | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | IRS2 | 25361965 | interaction type | N/A | PTMCode2 |
IRS2 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | PIK3CD | 25361965 | interaction type | N/A | PTMCode2 |
PIK3CD | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | FGFR1 | 25361965 | interaction type | N/A | PTMCode2 |
FGFR1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | TEK | 25361965 | interaction type | N/A | PTMCode2 |
TEK | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | SOS1 | 25361965 | interaction type | N/A | PTMCode2 |
SOS1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R2 | SHC1 | 25361965 | interaction type | N/A | PTMCode2 |
SHC1 | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GOLGA2 | PIK3R2 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | KRT38 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | KRT20 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | RINT1 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | MRFAP1L1 | 21516116 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | ERBB2 | 1334406 14525934 16273093 16729043 24234451 25348397 | physical association | experimental interaction detection,protein array,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | KIT | 14525934 24234451 24728074 25348397 7537096 | association | coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | CBL | 14525934 19380743 24234451 25348397 25814554 7629144 | association,physical association | experimental interaction detection,physical interaction,two hybrid array,in vivo,tandem affinity purification,validated two hybrid | ComPPI,HPRD,IntAct |
PIK3R2 | GRB2 | 14525934 19380743 20936779 21706016 24234451 25348397 8662998 | association,physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
PIK3R2 | AXL | 14525934 25348397 9178760 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
PIK3R2 | SHC1 | 14525934 19380743 24234451 25348397 8662998 | association | experimental interaction detection,physical interaction,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
PIK3R2 | CRKL | 14525934 25348397 9092574 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
PIK3R2 | SOCS6 | 12052866 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
PIK3R2 | EGFR | 11172806 14525934 16273093 24234451 24658140 25348397 | physical association | experimental interaction detection,protein array,ubiquitin reconstruction,physical interaction,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | PDGFRB | 11172806 1330535 14525934 24234451 25348397 | association | biophysical,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | CD28 | 14525934 25348397 7509360 8080844 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
PIK3R2 | IGF1R | 14525934 24234451 25348397 7541045 | physical association | two hybrid,experimental interaction detection,in vitro | ComPPI,HPRD,IntAct |
PIK3R2 | EPHA2 | 14525934 25348397 7982920 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
PIK3R2 | FGFR1 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
PIK3R2 | SOS1 | 14525934 25348397 9651378 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
PIK3R2 | TGFBR2 | 14525934 25348397 9435577 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
PIK3R2 | IRS2 | 10594015 14525934 25348397 9651378 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
PIK3R2 | SOCS7 | 12052866 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
PIK3R2 | YWHAB | 14525934 15324660 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | SOCS1 | 10022833 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
PIK3R2 | SYK | 14525934 15536084 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
PIK3R2 | ERBB4 | 14525934 16729043 24234451 25348397 | physical association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
PIK3R2 | SEPTIN2 | 14525934 17024187 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
PIK3R2 | EGF | 1334406 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
PIK3R2 | FYN | 1334406 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
PIK3R2 | HCK | 12029088 14525934 24234451 25348397 | physical association | experimental interaction detection,pull down,in vitro | ComPPI,HPRD,IntAct |
PIK3R2 | IRS1 | 11120660 12730242 14525934 25348397 7559478 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
PIK3R2 | CSF1R | 1334406 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
PIK3R2 | ERBB3 | 14525934 16273093 16729043 24189400 24234451 25348397 | association,physical association | experimental interaction detection,protein array,pull down,physical interaction,tandem affinity purification | ComPPI,HPRD,IntAct |
PIK3R2 | TEC | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PIK3CD | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TGFBR1 | 14525934 25348397 9435577 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
PIK3R2 | CCR5 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | ESR1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | ARRB1 | 17620599 21988832 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction,two hybrid array | ComPPI,IntAct |
PIK3R2 | CUL3 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | CD3E | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | CBLB | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | ABL1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | INPPL1 | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | PIK3CA | 19380743 22402981 24234451 25253337 25348397 26496610 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | PIK3CB | 19380743 22402981 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | IQGAP1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT10 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PTPN11 | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | HSPA8 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT9 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT5 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT6C | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | ACTB | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | MYH10 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | GAB2 | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | SEMG1 | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | KRT16 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | SEMG2 | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | KRT14 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TUBA1C | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HSPA1L | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | SPTBN1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT17 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HSPA1A | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HSPA1B | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT79 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PIK3R1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | CRK | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PIK3R2 | HSPA6 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | MYH9 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TUBB | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | ACACA | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT15 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | BCR | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | KRT4 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | CORO1C | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PIK3R3 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | EEF1A1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | DDX3X | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | RPS10 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | MYH14 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | FUS | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TUBB6 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | RPS5 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | RPS7 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | APP | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | VCP | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | VCAM1 | 22623428 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
PIK3R2 | MED28 | 16964398 24234451 25348397 | physical association | peptide array,physical interaction | ComPPI,IntAct |
PIK3R2 | ITGA4 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | FBXL2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | GRN | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
PIK3R2 | KRAS | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
PIK3R2 | LAMB2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
PIK3R2 | LTBP3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
PIK3R2 | STAB1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
PIK3R2 | ADARB2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | IRS4 | 24234451 25036637 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PIK3R2 | YWHAQ | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TRIM23 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | IKZF3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | DYDC1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PIK3R2 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | SQSTM1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | SKAP1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | VSIG4 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HAUS1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HAUS4 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | RCBTB2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PTGER3 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HEPACAM2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | NTRK1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | GHR | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | STAT3 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | APPL1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
PIK3R2 | PTEN | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | HAVCR2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | TMEM52B | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | RNF19B | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | MANSC1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | FLRT1 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | PRMT2 | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | LMNA | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | DLG1 | 24234451 25253337 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PIK3R2 | ABI1 | 20598684 24234451 25348397 | N/A | array technology | ComPPI,IntAct |
PIK3R2 | PTK2 | 22402981 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
PIK3R2 | SRC | 22402981 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
PIK3R2 | HTT | 17500595 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
PIK3R2 | AR | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PIK3R2 | GAB1 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PIK3R2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PIK3R2 | LAMP1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
PIK3R2 | MAPK6 | 24234451 25348397 29426014 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
WASF3 | PIK3R2 | 14525934 15826941 | N/A | experimental interaction detection,two hybrid | HPRD |
PIK3R2 | TRPV1 | 17074976 27898060 | N/A | N/A | OmniPath |
TGFBR2 | PIK3R2 | 26186194 27898060 9435577 | stimulant | N/A | OmniPath |
LAT | PIK3R2 | 11368773 27898060 | stimulant | N/A | OmniPath |
ESR1 | PIK3R2 | 16169518 27898060 | stimulant | N/A | OmniPath |
PIK3R2 | PIK3CA | 12147247 19380743 23604317 26496610 27898060 | N/A | N/A | OmniPath |
CBL | PIK3R2 | 11133830 11526404 15107835 19190244 19380743 25814554 27898060 7629144 8662998 9092574 | inhibition | N/A | OmniPath |
TGFBR1 | PIK3R2 | 27898060 9435577 | stimulant | N/A | OmniPath |
PIK3CD | PIK3R2 | 19380743 27898060 9113989 | N/A | N/A | OmniPath |
AXL | PIK3R2 | 27898060 9178760 | N/A | N/A | OmniPath |