Gene Information gene info

GENE:PIK3R2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3R2
FullNmae phosphoinositide-3-kinase regulatory subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8980
EnsembleID ENSG00000105647
Uniprot O00459

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3R2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIK3R2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIK3R2 GO:0001678,GO:0001784,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0005942,GO:0005943,GO:0005943,GO:0006955,GO:0008286,GO:0010506,GO:0015031,GO:0019903,GO:0030183,GO:0030217,GO:0030833,GO:0030971,GO:0032869,GO:0034976,GO:0036312,GO:0042307,GO:0043409,GO:0043491,GO:0043551,GO:0045785,GO:0045944,GO:0046854,GO:0046935,GO:0046982,GO:0051492,GO:1903076

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3R2 hsa:5296 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04210 Apoptosis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04218 Cellular senescence - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04360 Axon guidance - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04510 Focal adhesion - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04611 Platelet activation - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04929 GnRH secretion - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04931 Insulin resistance - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05020 Prion disease - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05131 Shigellosis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05135 Yersinia infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05142 Chagas disease - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05146 Amoebiasis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05160 Hepatitis C - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05161 Hepatitis B - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05162 Measles - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05164 Influenza A - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05210 Colorectal cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05213 Endometrial cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05214 Glioma - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05215 Prostate cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05218 Melanoma - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05224 Breast cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05226 Gastric cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
PIK3R2 hsa:5296 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIK3R2 PIK3CD 23180781 9113989 physical association gst pull down InnateDB
PIK3R2 PIK3CA 12147247 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3R2 AXL 23180781 9178760 physical association anti tag coimmunoprecipitation,far western blotting InnateDB
TRIM23 PIK3R2 23180781 25416956 physical association two hybrid InnateDB
EPHA2 PIK3R2 23331499 7982920 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB2 PIK3R2 20005715 interaction type N/A PSP
IRS1 PIK3R2 20005715 interaction type N/A PSP
IRS2 PIK3R2 20005715 interaction type N/A PSP
SHC1 PIK3R2 20005715 interaction type N/A PSP
SOCS1 PIK3R2 20005715 interaction type N/A PSP
SOCS6 PIK3R2 20005715 interaction type N/A PSP
SOCS7 PIK3R2 20005715 interaction type N/A PSP
YWHAB PIK3R2 20005715 interaction type N/A PSP
SOCS1 PIK3R2 20005715 20005715 N/A N/A SignaLink
YWHAB PIK3R2 15324660 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 PIK3R2 20005715 20005715 N/A N/A SignaLink
IRS2 PIK3R2 10594015 18988627 20005715 20005715 9651378 N/A N/A SignaLink
SHC1 PIK3R2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PIK3R2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PIK3R2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PIK3R2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PIK3R2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 PIK3R2 18663744 18987025 21249429 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00001D69F6 PIK3R2 18663744 18987025 21249429 24969300 25416803 26381870 27191494 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001C3AC1 PIK3R2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 PIK3R2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005CF5F PIK3R2 25416803 27165190 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 PIK3R2 25416803 27895663 mrna cleavage,inhibition western blot TarBase
URS00003380CC PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004A9320 PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PIK3R2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIK3R2 CSF1R 25361965 interaction type N/A PTMCode2
CSF1R PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 GAB1 25361965 interaction type N/A PTMCode2
GAB1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 PIK3CA 25361965 interaction type N/A PTMCode2
PIK3CA PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 CBL 25361965 interaction type N/A PTMCode2
CBL PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 CBLB 25361965 interaction type N/A PTMCode2
CBLB PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 EGF 25361965 interaction type N/A PTMCode2
EGF PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 IGF1R 25361965 interaction type N/A PTMCode2
IGF1R PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 ERBB2 25361965 interaction type N/A PTMCode2
ERBB2 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 EGFR 25361965 interaction type N/A PTMCode2
EGFR PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 KIT 25361965 interaction type N/A PTMCode2
KIT PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 MERTK 25361965 interaction type N/A PTMCode2
MERTK PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 INPPL1 25361965 interaction type N/A PTMCode2
INPPL1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 CRK 25361965 interaction type N/A PTMCode2
CRK PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 AXL 25361965 interaction type N/A PTMCode2
AXL PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 GAB2 25361965 interaction type N/A PTMCode2
GAB2 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 INSR 25361965 interaction type N/A PTMCode2
INSR PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 KHDRBS1 25361965 interaction type N/A PTMCode2
KHDRBS1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 CD28 25361965 interaction type N/A PTMCode2
CD28 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 GRB2 25361965 interaction type N/A PTMCode2
GRB2 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 CRKL 25361965 interaction type N/A PTMCode2
CRKL PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 FYN 25361965 interaction type N/A PTMCode2
FYN PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 SEMG2 25361965 interaction type N/A PTMCode2
SEMG2 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 SEMG1 25361965 interaction type N/A PTMCode2
SEMG1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 SYK 25361965 interaction type N/A PTMCode2
SYK PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 HCK 25361965 interaction type N/A PTMCode2
HCK PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 FGFR1 25361965 interaction type N/A PTMCode2
FGFR1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 TEK 25361965 interaction type N/A PTMCode2
TEK PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 PIK3R2 25361965 interaction type N/A PTMCode2
PIK3R2 SHC1 25361965 interaction type N/A PTMCode2
SHC1 PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 PIK3R2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 KRT38 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 KRT20 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 RINT1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 MRFAP1L1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 ERBB2 1334406 14525934 16273093 16729043 24234451 25348397 physical association experimental interaction detection,protein array,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PIK3R2 KIT 14525934 24234451 24728074 25348397 7537096 association coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3R2 CBL 14525934 19380743 24234451 25348397 25814554 7629144 association,physical association experimental interaction detection,physical interaction,two hybrid array,in vivo,tandem affinity purification,validated two hybrid ComPPI,HPRD,IntAct
PIK3R2 GRB2 14525934 19380743 20936779 21706016 24234451 25348397 8662998 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PIK3R2 AXL 14525934 25348397 9178760 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3R2 SHC1 14525934 19380743 24234451 25348397 8662998 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PIK3R2 CRKL 14525934 25348397 9092574 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3R2 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3R2 EGFR 11172806 14525934 16273093 24234451 24658140 25348397 physical association experimental interaction detection,protein array,ubiquitin reconstruction,physical interaction,in vivo ComPPI,HPRD,IntAct
PIK3R2 PDGFRB 11172806 1330535 14525934 24234451 25348397 association biophysical,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PIK3R2 CD28 14525934 25348397 7509360 8080844 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3R2 IGF1R 14525934 24234451 25348397 7541045 physical association two hybrid,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
PIK3R2 EPHA2 14525934 25348397 7982920 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PIK3R2 FGFR1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PIK3R2 SOS1 14525934 25348397 9651378 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3R2 TGFBR2 14525934 25348397 9435577 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R2 IRS2 10594015 14525934 25348397 9651378 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3R2 SOCS7 12052866 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R2 YWHAB 14525934 15324660 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PIK3R2 SOCS1 10022833 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R2 SYK 14525934 15536084 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIK3R2 ERBB4 14525934 16729043 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3R2 SEPTIN2 14525934 17024187 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R2 EGF 1334406 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R2 FYN 1334406 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R2 HCK 12029088 14525934 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
PIK3R2 IRS1 11120660 12730242 14525934 25348397 7559478 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PIK3R2 CSF1R 1334406 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R2 ERBB3 14525934 16273093 16729043 24189400 24234451 25348397 association,physical association experimental interaction detection,protein array,pull down,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
PIK3R2 TEC 25348397 N/A physical interaction ComPPI
PIK3R2 PIK3CD 25348397 N/A physical interaction ComPPI
PIK3R2 TGFBR1 14525934 25348397 9435577 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PIK3R2 CCR5 25348397 N/A physical interaction ComPPI
PIK3R2 ESR1 25348397 N/A physical interaction ComPPI
PIK3R2 ARRB1 17620599 21988832 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
PIK3R2 CUL3 25348397 N/A physical interaction ComPPI
PIK3R2 CD3E 25348397 N/A physical interaction ComPPI
PIK3R2 CBLB 25348397 N/A physical interaction ComPPI
PIK3R2 ABL1 25348397 N/A physical interaction ComPPI
PIK3R2 INPPL1 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 PIK3CA 19380743 22402981 24234451 25253337 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 PIK3CB 19380743 22402981 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 IQGAP1 25348397 N/A physical interaction ComPPI
PIK3R2 KRT1 25348397 N/A physical interaction ComPPI
PIK3R2 KRT2 25348397 N/A physical interaction ComPPI
PIK3R2 KRT10 25348397 N/A physical interaction ComPPI
PIK3R2 PTPN11 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 HSPA8 25348397 N/A physical interaction ComPPI
PIK3R2 KRT9 25348397 N/A physical interaction ComPPI
PIK3R2 KRT5 25348397 N/A physical interaction ComPPI
PIK3R2 KRT6C 25348397 N/A physical interaction ComPPI
PIK3R2 ACTB 25348397 N/A physical interaction ComPPI
PIK3R2 MYH10 25348397 N/A physical interaction ComPPI
PIK3R2 GAB2 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 SEMG1 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 KRT16 25348397 N/A physical interaction ComPPI
PIK3R2 SEMG2 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 KRT14 25348397 N/A physical interaction ComPPI
PIK3R2 TUBA1C 25348397 N/A physical interaction ComPPI
PIK3R2 HSPA1L 25348397 N/A physical interaction ComPPI
PIK3R2 SPTBN1 25348397 N/A physical interaction ComPPI
PIK3R2 KRT17 25348397 N/A physical interaction ComPPI
PIK3R2 HSPA1A 25348397 N/A physical interaction ComPPI
PIK3R2 HSPA1B 25348397 N/A physical interaction ComPPI
PIK3R2 KRT79 25348397 N/A physical interaction ComPPI
PIK3R2 PIK3R1 25348397 N/A physical interaction ComPPI
PIK3R2 CRK 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R2 HSPA6 25348397 N/A physical interaction ComPPI
PIK3R2 MYH9 25348397 N/A physical interaction ComPPI
PIK3R2 TUBB 25348397 N/A physical interaction ComPPI
PIK3R2 ACACA 25348397 N/A physical interaction ComPPI
PIK3R2 KRT15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 BCR 25348397 N/A physical interaction ComPPI
PIK3R2 KRT4 25348397 N/A physical interaction ComPPI
PIK3R2 CORO1C 25348397 N/A physical interaction ComPPI
PIK3R2 PIK3R3 25348397 N/A physical interaction ComPPI
PIK3R2 EEF1A1 25348397 N/A physical interaction ComPPI
PIK3R2 EEF1A1P5 25348397 N/A physical interaction ComPPI
PIK3R2 DDX3X 25348397 N/A physical interaction ComPPI
PIK3R2 RPS10 25348397 N/A physical interaction ComPPI
PIK3R2 MYH14 25348397 N/A physical interaction ComPPI
PIK3R2 FUS 25348397 N/A physical interaction ComPPI
PIK3R2 TUBB6 25348397 N/A physical interaction ComPPI
PIK3R2 RPS5 25348397 N/A physical interaction ComPPI
PIK3R2 RPS7 25348397 N/A physical interaction ComPPI
PIK3R2 APP 25348397 N/A physical interaction ComPPI
PIK3R2 VCP 25348397 N/A physical interaction ComPPI
PIK3R2 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PIK3R2 MED28 16964398 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
PIK3R2 ITGA4 25348397 N/A physical interaction ComPPI
PIK3R2 FBXL2 25348397 N/A physical interaction ComPPI
PIK3R2 GRN 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R2 KRAS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R2 LAMB2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R2 LTBP3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R2 STAB1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R2 ADARB2 25348397 N/A physical interaction ComPPI
PIK3R2 IRS4 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3R2 YWHAQ 25348397 N/A physical interaction ComPPI
PIK3R2 TRIM23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 IKZF3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 DYDC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 MOV10 25348397 N/A physical interaction ComPPI
PIK3R2 NXF1 25348397 N/A physical interaction ComPPI
PIK3R2 SQSTM1 25348397 N/A physical interaction ComPPI
PIK3R2 EFNB2 25348397 N/A physical interaction ComPPI
PIK3R2 SKAP1 25348397 N/A physical interaction ComPPI
PIK3R2 VSIG4 25348397 N/A physical interaction ComPPI
PIK3R2 HAUS1 25348397 N/A physical interaction ComPPI
PIK3R2 HAUS4 25348397 N/A physical interaction ComPPI
PIK3R2 RCBTB2 25348397 N/A physical interaction ComPPI
PIK3R2 PTGER3 25348397 N/A physical interaction ComPPI
PIK3R2 HEPACAM2 25348397 N/A physical interaction ComPPI
PIK3R2 NTRK1 25348397 N/A physical interaction ComPPI
PIK3R2 GHR 25348397 N/A physical interaction ComPPI
PIK3R2 STAT3 25348397 N/A physical interaction ComPPI
PIK3R2 APPL1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R2 PTEN 25348397 N/A physical interaction ComPPI
PIK3R2 HAVCR2 25348397 N/A physical interaction ComPPI
PIK3R2 TMEM52B 25348397 N/A physical interaction ComPPI
PIK3R2 RNF19B 25348397 N/A physical interaction ComPPI
PIK3R2 MANSC1 25348397 N/A physical interaction ComPPI
PIK3R2 FLRT1 25348397 N/A physical interaction ComPPI
PIK3R2 PRMT2 25348397 N/A physical interaction ComPPI
PIK3R2 LMNA 25348397 N/A physical interaction ComPPI
PIK3R2 DLG1 24234451 25253337 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3R2 ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
PIK3R2 PTK2 22402981 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3R2 SRC 22402981 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3R2 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIK3R2 AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R2 GAB1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PIK3R2 MAPK6 24234451 25348397 29426014 association anti tag coimmunoprecipitation ComPPI,IntAct
WASF3 PIK3R2 14525934 15826941 N/A experimental interaction detection,two hybrid HPRD
PIK3R2 TRPV1 17074976 27898060 N/A N/A OmniPath
TGFBR2 PIK3R2 26186194 27898060 9435577 stimulant N/A OmniPath
LAT PIK3R2 11368773 27898060 stimulant N/A OmniPath
ESR1 PIK3R2 16169518 27898060 stimulant N/A OmniPath
PIK3R2 PIK3CA 12147247 19380743 23604317 26496610 27898060 N/A N/A OmniPath
CBL PIK3R2 11133830 11526404 15107835 19190244 19380743 25814554 27898060 7629144 8662998 9092574 inhibition N/A OmniPath
TGFBR1 PIK3R2 27898060 9435577 stimulant N/A OmniPath
PIK3CD PIK3R2 19380743 27898060 9113989 N/A N/A OmniPath
AXL PIK3R2 27898060 9178760 N/A N/A OmniPath

Visualization