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GENE：TAB3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TAB3
FullNmae TGF-beta activated kinase 1 (MAP3K7) binding protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30681
EnsembleID ENSG00000157625
Uniprot Q8N5C8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TAB3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TAB3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TAB3 GO:0005515,GO:0005783,GO:0005829,GO:0005886,GO:0008270,GO:0010008,GO:0010507,GO:0038061,GO:0042742,GO:0043123,GO:0043123,GO:0043123,GO:0043130,GO:0060090,GO:0070062,GO:0070530

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TAB3 hsa:257397 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TAB3 hsa:257397 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TAB3 hsa:257397 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
TAB3 hsa:257397 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
TAB3 hsa:257397 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TAB3 hsa:257397 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TAB3 hsa:257397 path:hsa05131 Shigellosis - Homo sapiens (human)
TAB3 hsa:257397 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K7 TAB3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 21903422 22941947 23180781 23681101 24403530 24699077 24958845 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TAB2 TAB3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 21903422 22941947 23180781 23681101 24403530 24699077 24958845 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TAB3 IKBKG 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
TRAF6 TAB3 11274345 12150927 12620219 14633987 14660645 15125833 15327770 16252010 17948050 18264787 18758450 18922473 19161412 23180781 26192618 interaction type,physical association affinity chromatography technology,anti tag coimmunoprecipitation ACSN,InnateDB
FADD TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
RIPK1 TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TNF TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TRADD TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TRAF2 TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
ECSIT TAB3 10465784 25371197 26192618 interaction type N/A ACSN
TAB3 MAP2K4 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
TAB3 MAP2K3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
TAB3 MAP3K7 14633987 14670075 17158449 17384642 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB3 TAB2 14633987 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB1 TAB3 14670075 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB3 TRAF2 14633987 19150425 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD7 TAB3 17384642 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 TAB3 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 TAB3 12609980 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB3 DYNC2I2 19521662 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TAB3 TAB1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG TAB3 15327770 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB3 TAB3 14670075 26467481 bind,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
E2F4 TAB3 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TAB3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TAB3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A TAB3 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TAB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000040EE1D TAB3 23487264 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000183BED TAB3 22660635 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000183BED TAB3 22660635 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000040EE1D TAB3 23487264 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000083D87 TAB3 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TAB3 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 TAB3 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 TAB3 25416803 25580008 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000065D58 TAB3 25416803 26555189 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PIN1 TAB3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM38 TAB3 25348397 N/A physical interaction ComPPI
DYNC2I2 TAB3 25348397 N/A physical interaction ComPPI
TRAF6 TAB3 12496252 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
TAB3 TRAF2 25348397 N/A physical interaction,in vivo ComPPI
TAB3 MAP3K7CL 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TAB3 MAP3K7 21903422 22081109 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TAB3 TAB1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB3 TAB2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB3 CALCOCO2 25348397 N/A physical interaction ComPPI
TAB3 BECN1 22081109 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
TAB3 UBC 25348397 N/A pull down,physical interaction,physical interaction ComPPI
TAB3 IKBKG 25348397 N/A physical interaction ComPPI
TAB3 RBCK1 25348397 N/A physical interaction ComPPI
TAB3 SMAD7 25348397 N/A physical interaction ComPPI
TAB3 TRIM5 25348397 N/A physical interaction ComPPI
TAB3 ATG5 25348397 N/A physical interaction ComPPI
TAB3 ATG13 25348397 N/A physical interaction ComPPI
TAB3 CEP57L1 25348397 N/A physical interaction ComPPI
TAB3 ESR1 25348397 N/A physical interaction ComPPI
TAB3 RNF4 25348397 N/A physical interaction ComPPI
TAB3 PBXIP1 25348397 N/A physical interaction ComPPI
TAB3 IKBKB 25348397 N/A physical interaction ComPPI
TAB3 CARD11 25348397 N/A physical interaction ComPPI
TAB3 EMILIN1 25348397 N/A physical interaction ComPPI
TAB3 CYLD 25348397 N/A physical interaction ComPPI
TAB3 UBA52 25348397 N/A pull down,physical interaction ComPPI
TAB3 YBX1 23986595 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TAB3 LINC00518 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBB TAB3 25348397 N/A pull down,physical interaction ComPPI
RPS27A TAB3 25348397 N/A pull down,physical interaction ComPPI
MAP3K7 TAB3 14633987 14670075 17158449 17384642 18021073 19232515 19955178 21903422 22081109 24912525 27898060 N/A N/A OmniPath
TAB3 MAP3K7 14633987 14670075 17158449 17384642 18021073 19232515 19955178 21903422 22081109 24912525 27898060 stimulant N/A OmniPath
MAPKAPK2 TAB3 18021073 27898060 N/A N/A OmniPath
TRAF2 TAB3 14633987 19150425 27898060 N/A N/A OmniPath
TAB3 TRAF2 14633987 19150425 27898060 N/A N/A OmniPath
MAPKAPK3 TAB3 18021073 27898060 N/A N/A OmniPath
TAB3 TRAF6 14633987 15327770 25290089 27898060 N/A N/A OmniPath
TRAF6 TAB3 14633987 15327770 25290089 27898060 stimulant N/A OmniPath
TAB3 IKBKG 15327770 23986494 27898060 stimulant N/A OmniPath
TAB3 TAB2 14633987 21903422 27898060 stimulant N/A OmniPath
TAB2 TAB3 14633987 21903422 27898060 N/A N/A OmniPath
RIPK1 TAB3 19927120 27898060 stimulant N/A OmniPath
TLR3 TAB3 12609980 27898060 stimulant N/A OmniPath
TAB1 TAB3 14670075 18021073 21903422 27898060 N/A N/A OmniPath
TAB3 TAB1 14670075 18021073 21903422 27898060 N/A N/A OmniPath
DYNC2I2 TAB3 19521662 27898060 N/A N/A OmniPath
SMAD7 TAB3 17384642 27898060 stimulant N/A OmniPath
TAB3 SMAD7 17384642 27898060 N/A N/A OmniPath
TAB3 RBCK1 17449468 27898060 N/A N/A OmniPath
RBCK1 TAB3 17449468 27898060 N/A N/A OmniPath

Visualization










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