GENE：ZC3H12A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ZC3H12A |
| FullNmae | zinc finger CCCH-type containing 12A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:26259 |
| EnsembleID | ENSG00000163874 |
| Uniprot | Q5D1E8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ZC3H12A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ZC3H12A | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ZC3H12A | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ZC3H12A | GO:0000184,GO:0000932,GO:0001525,GO:0001933,GO:0002230,GO:0002757,GO:0003677,GO:0003682,GO:0003723,GO:0003729,GO:0003729,GO:0003730,GO:0004521,GO:0004521,GO:0004532,GO:0004540,GO:0004843,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005856,GO:0006915,GO:0006954,GO:0006974,GO:0007399,GO:0010468,GO:0010508,GO:0010587,GO:0010595,GO:0010628,GO:0010629,GO:0010656,GO:0010884,GO:0016579,GO:0030154,GO:0030867,GO:0032088,GO:0032689,GO:0032691,GO:0032715,GO:0032715,GO:0032720,GO:0032720,GO:0032991,GO:0034599,GO:0035198,GO:0035613,GO:0035925,GO:0036464,GO:0036464,GO:0042149,GO:0042307,GO:0043022,GO:0043031,GO:0043124,GO:0043124,GO:0044828,GO:0045019,GO:0045600,GO:0045766,GO:0045766,GO:0045944,GO:0046872,GO:0050852,GO:0051259,GO:0051607,GO:0055118,GO:0061014,GO:0061014,GO:0061158,GO:0061158,GO:0061158,GO:0071222,GO:0071222,GO:0071347,GO:0071356,GO:0098586,GO:1900016,GO:1900119,GO:1900745,GO:1901223,GO:1903003,GO:1903936,GO:1904637,GO:1990869,GO:2000320,GO:2000379,GO:2000627 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | ZC3H12A | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | ZC3H12A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ZC3H12A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | ZC3H12A | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ZC3H12A | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ZC3H12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KPNA2 | ZC3H12A | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AIMP2 | ZC3H12A | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TRAF6 | ZC3H12A | 25348397 | N/A | physical interaction | ComPPI |
| AHSP | ZC3H12A | 14525934 16189514 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| ZC3H12A | SHBG | 14525934 15862967 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| ZC3H12A | TANK | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ZC3H12A | IRAK2 | 21903422 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ZC3H12A | BTRC | 21900206 21988832 24234451 24270572 25348397 | association,physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| ZC3H12A | SMAD3 | 21988832 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| ZC3H12A | EP300 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ZC3H12A | CYFIP2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ZC3H12A | IKBKG | 24234451 24270572 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ZC3H12A | UBC | 21115689 24270572 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| ZC3H12A | USP10 | 24234451 24270572 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ZC3H12A | P4HA3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ZC3H12A | XPO1 | 25348397 | N/A | physical interaction | ComPPI |
| ZC3H12A | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| ZC3H12A | HIF1A | 25348397 | N/A | physical interaction | ComPPI |
| ZC3H12A | CEBPB | 25348397 | N/A | physical interaction | ComPPI |
| ZC3H12A | IKBKB | 22037600 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ZC3H12A | DNAJB13 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ZC3H12A | LNX1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |