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GENE：GSK3A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSK3A
FullNmae glycogen synthase kinase 3 alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4616
EnsembleID ENSG00000105723
Uniprot P49840

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSK3A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSK3A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GSK3A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSK3A apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GSK3A GO:0003073,GO:0003214,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0005977,GO:0006349,GO:0006468,GO:0007212,GO:0007399,GO:0008286,GO:0008286,GO:0010508,GO:0010628,GO:0010800,GO:0010905,GO:0010975,GO:0016055,GO:0016477,GO:0018107,GO:0019082,GO:0030424,GO:0030877,GO:0030877,GO:0031398,GO:0032007,GO:0032007,GO:0032436,GO:0032869,GO:0033138,GO:0034236,GO:0036016,GO:0043025,GO:0043161,GO:0043161,GO:0044027,GO:0045719,GO:0045732,GO:0045823,GO:0045944,GO:0046325,GO:0046627,GO:0048156,GO:0050321,GO:0050321,GO:0060079,GO:0061052,GO:0071285,GO:0071385,GO:0071879,GO:0090090,GO:0090090,GO:0097191,GO:0097192,GO:0097192,GO:0097440,GO:0098794,GO:0106071,GO:0106310,GO:1901030,GO:1902004,GO:1902004,GO:1903146,GO:1903955,GO:1904227,GO:1990635,GO:2000077,GO:2000466,GO:2000467

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSK3A hsa:2931 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
GSK3A hsa:2931 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
GSK3A hsa:2931 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
GSK3A hsa:2931 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GSK3A GSK3A 18701488 26467481 7566348 7706316 9771888 phosphorylation reaction,up-regulates,down-regulates,down-regulates activity N/A Signor
GSK3A TSC2 20226003 23331499 stimulation N/A SignaLink,SignaLink
GSK3A LTC4S 19740771 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AXIN1 GSK3A 20005715 interaction type N/A PSP,SignaLink
PXN GSK3A 20005715 interaction type N/A PSP,SignaLink
YWHAG GSK3A 20005715 interaction type N/A PSP
YWHAG GSK3A 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 GSK3A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GSK3A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GSK3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 GSK3A 11579131 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 GSK3A 11579131 trascriptional regulation,stimulation inferred by curator TFlink
RELA GSK3A 11579131 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE GSK3A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D GSK3A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 GSK3A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 GSK3A 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD GSK3A 22135298 phosphorylation N/A PhosphoSite
PRKACA GSK3A 22135298 phosphorylation N/A PhosphoSite
IKBKE GSK3A 22135298 phosphorylation N/A PhosphoSite
GSK3A LRP6 22135298 phosphorylation N/A PhosphoSite
GSK3A BCL3 22135298 phosphorylation N/A PhosphoSite
GSK3A GSK3A 22135298 phosphorylation N/A PhosphoSite
GSK3A USF1 22135298 phosphorylation N/A PhosphoSite
GSK3A IL17RA 22135298 phosphorylation N/A PhosphoSite
GSK3A CTNNB1 22135298 phosphorylation N/A PhosphoSite
GSK3A NDRG1 22135298 phosphorylation N/A PhosphoSite
GSK3A MAP3K11 22135298 phosphorylation N/A PhosphoSite
GSK3A CCNE1 22135298 phosphorylation N/A PhosphoSite
GSK3A RICTOR 22135298 phosphorylation N/A PhosphoSite
GSK3A MYC 22135298 phosphorylation N/A PhosphoSite
GSK3A CTPS1 22135298 phosphorylation N/A PhosphoSite
GSK3A NIFK 22135298 phosphorylation N/A PhosphoSite
GSK3A PKD2 22135298 phosphorylation N/A PhosphoSite
GSK3A BCL2L1 22135298 phosphorylation N/A PhosphoSite
GSK3A ANKRD28 22135298 phosphorylation N/A PhosphoSite
GSK3A UNG 22135298 phosphorylation N/A PhosphoSite
GSK3A STMN3 22135298 phosphorylation N/A PhosphoSite
GSK3A AKT1 22135298 phosphorylation N/A PhosphoSite
GSK3A DPYSL2 22135298 phosphorylation N/A PhosphoSite
PRKCH GSK3A 22135298 phosphorylation N/A PhosphoSite
PRKCA GSK3A 22135298 phosphorylation N/A PhosphoSite
PRKCB GSK3A 22135298 phosphorylation N/A PhosphoSite
PRKCG GSK3A 22135298 phosphorylation N/A PhosphoSite
AKT1 GSK3A 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 GSK3A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PPP1CC GSK3A 25348397 N/A physical interaction ComPPI
YWHAG GSK3A 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP1R2B GSK3A 25348397 N/A physical interaction ComPPI
PPP1CB GSK3A 25348397 N/A physical interaction ComPPI
HSP90AB1 GSK3A 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
BCL2L1 GSK3A 25348397 N/A physical interaction ComPPI
PRKCA GSK3A 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCD GSK3A 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC GSK3A 25348397 N/A physical interaction ComPPI
FCGR2B GSK3A 25348397 N/A physical interaction ComPPI
AR GSK3A 25348397 N/A physical interaction ComPPI
GLI3 GSK3A 25348397 N/A physical interaction ComPPI
PRKACA GSK3A 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ARHGEF11 GSK3A 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
NBR1 GSK3A 20368287 24234451 24879152 25348397 phosphorylation reaction,physical association pull down,physical interaction,protein kinase assay ComPPI,IntAct
HSP90AA1 GSK3A 25348397 N/A physical interaction ComPPI
AXIN1 GSK3A 17318175 17510365 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
AXIN2 GSK3A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MCL1 GSK3A 14525934 16543145 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP1CA GSK3A 25348397 N/A physical interaction ComPPI
MYC GSK3A 25348397 N/A physical interaction ComPPI
PRKCB GSK3A 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PXN GSK3A 25348397 N/A in vivo ComPPI
PRKCH GSK3A 25348397 N/A physical interaction ComPPI
MAPT GSK3A 16446437 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay,in vitro ComPPI,IntAct
PRKCZ GSK3A 11481324 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A PRKCG 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GSK3A EIF2B5 11500362 14525934 15302935 25348397 9468292 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A PRKD3 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A SGK3 11035810 11749387 11884598 12054501 14525934 16543730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A LRSAM1 14525934 14635195 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GSK3A BCL3 14525934 15469820 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GSK3A CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A HSF1 12665592 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A SGK1 14525934 16543730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A AKT1 11035810 11884598 14525934 25348397 8524413 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GSK3A HDAC6 25348397 N/A physical interaction ComPPI
GSK3A CREB1 25348397 N/A physical interaction ComPPI
GSK3A HSP90AA2P 25348397 N/A physical interaction ComPPI
GSK3A DEAF1 20368287 24234451 25348397 physical association pull down,physical interaction,protein kinase assay ComPPI,IntAct
GSK3A SPICE1 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
GSK3A MAP3K11 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
GSK3A VTA1 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
GSK3A GSKIP 20368287 23602568 24234451 25348397 association,physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,tandem affinity purification ComPPI,IntAct
GSK3A SPG21 20368287 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GSK3A KRBA1 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
GSK3A FAM193B 25348397 N/A physical interaction ComPPI
GSK3A PSMD1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3A PPP1R2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3A FRAT1 10481074 23602568 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
GSK3A AKAP9 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3A ZDHHC17 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
GSK3A TRAK2 25348397 N/A physical interaction ComPPI
GSK3A PPP3CC 25348397 N/A physical interaction ComPPI
GSK3A RCAN2 25348397 N/A physical interaction ComPPI
GSK3A RICTOR 25348397 N/A physical interaction ComPPI
GSK3A CTNNB1 17510365 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3A RAE1 25348397 N/A physical interaction ComPPI
GSK3A CRYBG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GSK3A CTNNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GSK3A MDN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GSK3A POLR3B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GSK3A FOXM1 25348397 N/A physical interaction ComPPI
GSK3A PPP3CB 25348397 N/A physical interaction ComPPI
GSK3A RCAN1 25348397 N/A physical interaction ComPPI
GSK3A SAMHD1 25348397 N/A physical interaction ComPPI
GSK3A FBXO42 25348397 N/A physical interaction ComPPI
GSK3A SRBD1 25348397 N/A physical interaction ComPPI
GSK3A ARSG 25348397 N/A physical interaction ComPPI
GSK3A TRIM25 25348397 N/A physical interaction ComPPI
GSK3A BICD1 14525934 17139249 24234451 25348397 colocalization cosedimentation through density gradient,experimental interaction detection ComPPI,HPRD,IntAct
GSK3A APP 16446437 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
GSK3A LRP6 16365045 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PKM GSK3A 25348397 N/A protein kinase assay ComPPI
EBNA1BP2 GSK3A 25348397 N/A physical interaction ComPPI
GSK3A GSK3A 14525934 17192257 N/A experimental interaction detection HPRD
TANK GSK3A 24234451 30561431 association virotrap IntAct
GSK3A PKD2 16551655 27898060 N/A N/A OmniPath
PRKACA GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 inhibition N/A OmniPath
PRKCA GSK3A 11035810 11749387 11803463 11884598 11896604 12054501 12515807 1324914 14556709 15333638 15755769 18691976 19117997 19413330 27898060 inhibition N/A OmniPath
GSK3A CTNNB1 25897075 26496610 27898060 9482734 9601641 inhibition N/A OmniPath
CAMK2B GSK3A 20841359 27898060 inhibition N/A OmniPath
PRKCB GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 inhibition N/A OmniPath
GSK3A DPYSL2 10757975 15466863 15652488 17683481 17902168 27898060 N/A N/A OmniPath
PRKCD GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 inhibition N/A OmniPath
GSK3A CREB1 27898060 7798217 stimulant N/A OmniPath
GSK3A MITF 10587587 27898060 stimulant N/A OmniPath
GSK3A CCNE1 14536078 27898060 N/A N/A OmniPath
GSK3A SFPQ 20932480 27898060 inhibition N/A OmniPath
GSK3A MYC 14563837 16023596 27898060 inhibition N/A OmniPath
CAPN3 GSK3A 25969760 27898060 stimulant N/A OmniPath
CAPN1 GSK3A 25969760 27898060 stimulant N/A OmniPath
AKT1 GSK3A 11035810 11509608 11749387 11884598 12054501 14645548 15678105 17192257 17505062 18691976 18851840 19369195 19413330 19995607 20576936 21775285 27898060 8524413 inhibition N/A OmniPath
GSK3A AKT1 11035810 11509608 11884598 14645548 15678105 17505062 18851840 19995607 20576936 21775285 23142783 27898060 8524413 N/A N/A OmniPath
GSK3A MAF 18042454 27898060 inhibition,stimulant N/A OmniPath
PRKCG GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 inhibition N/A OmniPath
GSK3A LRP6 14731402 16365045 20229235 27898060 stimulant N/A OmniPath
GSK3A BCL3 15469820 27898060 inhibition,stimulant N/A OmniPath
CAPN2 GSK3A 25969760 27898060 stimulant N/A OmniPath
GSK3A MCL1 16543145 27898060 inhibition N/A OmniPath
GSK3A CAMKK2 22778263 27898060 inhibition N/A OmniPath
GSK3A HSF1 12665592 18212344 18669648 19413330 19651622 19664994 20068231 20166139 27898060 N/A N/A OmniPath
GSK3A GYS1 14593110 27898060 inhibition N/A OmniPath
GSK3A TSC2 16959574 20226003 27898060 stimulant N/A OmniPath
RPS6KA3 GSK3A 11583116 27898060 inhibition N/A OmniPath
SGK1 GSK3A 11035810 11749387 11884598 12054501 16543730 18691976 19413330 27898060 N/A N/A OmniPath
GSK3A NOTCH1 19214430 27898060 inhibition N/A OmniPath
GSK3A USF1 11532965 16622840 19389701 21873430 27898060 N/A N/A OmniPath
AXIN1 GSK3A 10196136 11707456 17318175 19131971 23602568 23959799 26496610 27898060 9482734 9501208 9601641 stimulant N/A OmniPath
CSNK2A1 GSK3A 11035810 11340086 11563975 11577096 11749387 11884598 27898060 N/A N/A OmniPath
GSK3A PSEN1 11104755 27898060 9689133 inhibition N/A OmniPath
GSK3A MAPT 11007782 16446437 27898060 7566348 7706316 7931292 8228990 8799840 9689133 9735171 9771888 inhibition N/A OmniPath
AKT2 GSK3A 16023596 27898060 inhibition N/A OmniPath
PPP2R5C GSK3A 11897496 27898060 8524413 stimulant N/A OmniPath
GSK3A JUN 11075956 1516134 16023596 1846781 1956339 27898060 inhibition N/A OmniPath
GSK3A NFATC1 11063740 27898060 inhibition N/A OmniPath
PRKD3 GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 N/A N/A OmniPath
GSK3A MAP3K11 11969422 17711861 20368287 27898060 N/A N/A OmniPath
GSK3A MAFB 18042454 27898060 inhibition,stimulant N/A OmniPath
ILK GSK3A 27898060 9736715 inhibition N/A OmniPath
GSK3A SERPINB2 27898060 6090457 6091765 stimulant N/A OmniPath
GSK3A CREM 27898060 8404858 N/A N/A OmniPath
GSK3A ANAPC1 27898060 8638126 9601641 stimulant N/A OmniPath
GSK3A MAFA 18042454 27898060 inhibition,stimulant N/A OmniPath
SGK3 GSK3A 11035810 11749387 11884598 12054501 16543730 18691976 19413330 27898060 inhibition N/A OmniPath
GSK3A GATA6 27273097 27898060 inhibition N/A OmniPath
GSK3A CTPS1 17681942 27898060 N/A N/A OmniPath
GSK3A EIF2B5 11500362 15302935 18088087 18452278 18669648 18691976 18707149 19007248 19413330 19651622 19664994 20068231 20166139 27898060 9468292 inhibition N/A OmniPath
PRKCH GSK3A 11884598 27898060 inhibition N/A OmniPath
GSK3A ANKRD28 16564677 17023142 27898060 N/A N/A OmniPath
GSK3A NIFK 11342549 16244663 27898060 N/A N/A OmniPath

Visualization










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