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GENE：CLN3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLN3
FullNmae CLN3 lysosomal/endosomal transmembrane protein, battenin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2074
EnsembleID ENSG00000188603
Uniprot Q13286

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLN3 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CLN3 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CLN3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLN3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLN3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CLN3 GO:0000139,GO:0001508,GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005764,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005769,GO:0005770,GO:0005770,GO:0005770,GO:0005776,GO:0005783,GO:0005789,GO:0005794,GO:0005794,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0005886,GO:0005901,GO:0005901,GO:0006898,GO:0007040,GO:0007040,GO:0007042,GO:0007042,GO:0007611,GO:0008021,GO:0008306,GO:0009992,GO:0010762,GO:0016020,GO:0016243,GO:0016485,GO:0030036,GO:0031901,GO:0031902,GO:0032228,GO:0035235,GO:0035752,GO:0036359,GO:0042133,GO:0042987,GO:0042998,GO:0043005,GO:0043066,GO:0043066,GO:0043086,GO:0043524,GO:0043534,GO:0044754,GO:0044857,GO:0045121,GO:0045121,GO:0045861,GO:0046474,GO:0046836,GO:0047496,GO:0048172,GO:0048306,GO:0048549,GO:0050885,GO:0051480,GO:0051489,GO:0051493,GO:0051861,GO:0051966,GO:0055037,GO:0061024,GO:0061909,GO:0070613,GO:0072659,GO:0090160,GO:0090384,GO:0090385,GO:0097352,GO:0106049,GO:0120146,GO:1900079,GO:1901096,GO:1903076,GO:1903826,GO:1905146,GO:1905162,GO:1905244,GO:2001288

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLN3 hsa:1201 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FADS2 CLN3 23180781 23464991 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CLN3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 CLN3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CLN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC CLN3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D CLN3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SBDS CLN3 25361965 interaction type N/A PTMCode2
CLN3 SBDS 25361965 interaction type N/A PTMCode2
CLN6 CLN3 25361965 interaction type N/A PTMCode2
CLN3 CLN6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TFRC CLN3 25348397 N/A physical interaction ComPPI
RPN1 CLN3 25348397 N/A physical interaction ComPPI
DPM1 CLN3 25348397 N/A physical interaction ComPPI
EMD CLN3 25348397 N/A physical interaction ComPPI
SLC25A6 CLN3 25348397 N/A physical interaction ComPPI
SAMM50 CLN3 25348397 N/A physical interaction ComPPI
DDX20 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTH1R CLN3 25348397 N/A physical interaction ComPPI
ABCD3 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARF3 CLN3 25348397 N/A physical interaction ComPPI
FAR1 CLN3 25348397 N/A physical interaction ComPPI
ESYT2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CKAP4 CLN3 25348397 N/A physical interaction ComPPI
PHB CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61A2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO5 CLN3 25348397 N/A physical interaction ComPPI
IRAK1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TMPO CLN3 25348397 N/A physical interaction ComPPI
UNC45A CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 CLN3 25348397 N/A physical interaction ComPPI
UQCRC2 CLN3 25348397 N/A physical interaction ComPPI
CSE1L CLN3 25348397 N/A physical interaction ComPPI
AUP1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 CLN3 25348397 N/A physical interaction ComPPI
SSR4 CLN3 25348397 N/A physical interaction ComPPI
CAND1 CLN3 25348397 N/A physical interaction ComPPI
FKBP8 CLN3 25348397 N/A physical interaction ComPPI
IMMT CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNIP3 CLN3 17189291 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ELAVL1 CLN3 25348397 N/A physical interaction ComPPI
RIF1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARF4 CLN3 25348397 N/A physical interaction ComPPI
XPOT CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GANAB CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HACD3 CLN3 25348397 N/A physical interaction ComPPI
ADGRL2 CLN3 25348397 N/A physical interaction ComPPI
TRIP13 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG7 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP205 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP93 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61A1 CLN3 25348397 N/A physical interaction ComPPI
SLC25A10 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RCN2 CLN3 25348397 N/A physical interaction ComPPI
SLC25A5 CLN3 25348397 N/A physical interaction ComPPI
CPT1A CLN3 25348397 N/A physical interaction ComPPI
SLC25A3 CLN3 25348397 N/A physical interaction ComPPI
SLC25A4 CLN3 25348397 N/A physical interaction ComPPI
PHGDH CLN3 25348397 N/A physical interaction ComPPI
CYC1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A11 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ILVBL CLN3 25348397 N/A physical interaction ComPPI
CCDC47 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPN2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL12 CLN3 25348397 N/A physical interaction ComPPI
AFG3L2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DBH CLN3 25348397 N/A physical interaction ComPPI
FANCI CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP5MG CLN3 25348397 N/A physical interaction ComPPI
TMEM33 CLN3 25348397 N/A physical interaction ComPPI
SCAMP3 CLN3 25348397 N/A physical interaction ComPPI
ARF5 CLN3 25348397 N/A physical interaction ComPPI
SIGMAR1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CALU CLN3 25348397 N/A physical interaction ComPPI
ECPAS CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GEMIN4 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GCN1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDOST CLN3 25348397 N/A physical interaction ComPPI
ARMC6 CLN3 25348397 N/A physical interaction ComPPI
TELO2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPEPPS CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A22 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SFXN1 CLN3 25348397 N/A physical interaction ComPPI
SLC25A1 CLN3 25348397 N/A physical interaction ComPPI
RARS2 CLN3 25348397 N/A physical interaction ComPPI
TMPO CLN3 25348397 N/A physical interaction ComPPI
CLN3 SBDS 25348397 N/A physical interaction ComPPI
CLN3 COX15 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLN3 HSD17B12 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLN3 SFXN4 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLN3 SLC25A13 25348397 N/A physical interaction ComPPI
CLN3 SFXN3 25348397 N/A physical interaction ComPPI
CLN3 TECR 25348397 N/A physical interaction ComPPI
CLN3 FADS2 25348397 N/A physical interaction ComPPI
CLN3 ERLIN2 25348397 N/A physical interaction ComPPI
CLN3 MICOS13 25348397 N/A physical interaction ComPPI
CLN3 CDS2 25348397 N/A physical interaction ComPPI
CLN3 STRA6 25348397 N/A physical interaction ComPPI
CLN3 LPGAT1 25348397 N/A physical interaction ComPPI
CLN3 SLC35B2 25348397 N/A physical interaction ComPPI
CLN3 B3GALT2 25348397 N/A physical interaction ComPPI
CLN3 CLN3 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
CDK1 CLN3 12024050 1316273 16200502 23339867 24186061 27898060 7823941 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B9B51 CLN3 27087310 direct interaction,inhibition N/A NPInter

Visualization










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