GENE：IAPP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IAPP |
| FullNmae | islet amyloid polypeptide |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5329 |
| EnsembleID | ENSG00000121351 |
| Uniprot | P10997 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IAPP | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IAPP | GO:0001540,GO:0005102,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0007165,GO:0007189,GO:0007204,GO:0007267,GO:0008289,GO:0010739,GO:0010823,GO:0019233,GO:0030316,GO:0031333,GO:0042755,GO:0042802,GO:0043065,GO:0043410,GO:0045453,GO:0045671,GO:0045779,GO:0051897,GO:0097647,GO:1905907 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IAPP | hsa:3375 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| IAPP | hsa:3375 | path:hsa04950 | Maturity onset diabetes of the young - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FOS | IAPP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA4 | IAPP | 17290010 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | IAPP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | IAPP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF2 | IAPP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | IAPP | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | IAPP | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000016E46F | IAPP | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C28B2 | IAPP | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000105D19 | IAPP | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| P4HB | IAPP | 25348397 | N/A | physical interaction | ComPPI |
| PDX1 | IAPP | 14525934 25348397 27898060 9115263 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| IAPP | IDE | 25348397 | N/A | molecular sieving,x-ray crystallography,physical interaction,protease assay,protein cleavage | ComPPI |
| COL25A1 | IAPP | 14525934 15522881 | N/A | experimental interaction detection | HPRD |
| IAPP | CALCR | 10342886 24169554 27898060 9487987 | stimulant | N/A | OmniPath |