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GENE：ITPR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITPR1
FullNmae inositol 1,4,5-trisphosphate receptor type 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6180
EnsembleID ENSG00000150995
Uniprot Q14643

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITPR1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITPR1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITPR1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ITPR1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITPR1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ITPR1 GO:0000902,GO:0001666,GO:0005220,GO:0005220,GO:0005220,GO:0005509,GO:0005515,GO:0005637,GO:0005730,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0005886,GO:0005955,GO:0006816,GO:0007165,GO:0007207,GO:0009791,GO:0010506,GO:0014069,GO:0015085,GO:0015278,GO:0016020,GO:0016529,GO:0019855,GO:0019904,GO:0030658,GO:0030667,GO:0031088,GO:0031094,GO:0031095,GO:0032024,GO:0032469,GO:0035091,GO:0035091,GO:0042045,GO:0048471,GO:0050849,GO:0050882,GO:0051209,GO:0051209,GO:0070059,GO:0070679,GO:0098685,GO:0098695,GO:0099105,GO:0099566,GO:1990806

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITPR1 hsa:3708 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04210 Apoptosis - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04218 Cellular senescence - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04540 Gap junction - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04611 Platelet activation - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04713 Circadian entrainment - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04720 Long-term potentiation - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04730 Long-term depression - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04924 Renin secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04929 GnRH secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04934 Cushing syndrome - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04970 Salivary secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05012 Parkinson disease - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05016 Huntington disease - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05020 Prion disease - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05131 Shigellosis - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ITPR1 hsa:3708 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITPR1 STARD13 14697242 23180781 physical association two hybrid InnateDB
ITPR1 BECN1 19325567 23180781 physical association anti tag coimmunoprecipitation InnateDB
AHCYL1 ITPR1 11904675 16754674 29145629 physical association inferred by curator Reactome
ITPR2 ITPR1 17429043 24243840 29145629 physical association inferred by curator Reactome
ITPR1 ITPR1 17429043 24243840 29145629 physical association inferred by curator Reactome
ITPR3 ITPR1 17429043 24243840 29145629 physical association inferred by curator Reactome
STIM1 ITPR1 18187424 18596693 19249086 29145629 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
HOMER1 ITPR1 20005715 interaction type N/A PSP
HOMER2 ITPR1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR ITPR1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ITPR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ITPR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ITPR1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ITPR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ITPR1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ITPR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ITPR1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F0F49 ITPR1 20065103 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 ITPR1 20065103 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 ITPR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000007FBA ITPR1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00002FC5B0 ITPR1 20371350 21572407 22473208 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000C85B2 ITPR1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F ITPR1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 ITPR1 20371350 21572407 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 ITPR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C ITPR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D ITPR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 ITPR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000044FD7 ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000535FDD ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00002C7B2B ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000027352D ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001F5B39 ITPR1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00003A5E54 ITPR1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 ITPR1 22135298 phosphorylation N/A PhosphoSite
FYN ITPR1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CA8 ITPR1 12611586 14525934 25348397 26186194 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
ERLIN1 ITPR1 25348397 N/A physical interaction ComPPI
VCP ITPR1 25348397 N/A physical interaction ComPPI
CALM1 ITPR1 25348397 N/A physical interaction ComPPI
FKBP1A ITPR1 14525934 16278292 25348397 27898060 8521476 9346894 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
TAFA4 ITPR1 25348397 N/A physical interaction ComPPI
LYN ITPR1 11782428 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCD ITPR1 25348397 N/A physical interaction ComPPI
BANK1 ITPR1 11782428 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOA ITPR1 12766172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKACA ITPR1 12529267 14525934 25348397 8132598 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ARHGAP1 ITPR1 14525934 14697242 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TRPC1 ITPR1 25348397 N/A physical interaction ComPPI
PRKG1 ITPR1 14525934 18757735 24234451 25348397 8132598 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RYR2 ITPR1 12754204 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
SDC2 ITPR1 25348397 N/A physical interaction ComPPI
TRPC3 ITPR1 11524429 12606542 14525934 15104175 15623527 25348397 9853757 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRM1 ITPR1 25348397 N/A in vivo ComPPI
VDAC1 ITPR1 24234451 24947355 25348397 colocalization,physical association fluorescence microscopy,proximity ligation assay ComPPI,IntAct
STARD13 ITPR1 14525934 14697242 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
HOMER2 ITPR1 14525934 25348397 9808459 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HOMER3 ITPR1 14525934 25348397 9808459 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HOMER1 ITPR1 14525934 25348397 9808459 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPB41L1 ITPR1 12444087 12676536 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TRPC6 ITPR1 25348397 N/A physical interaction ComPPI
CCNB1 ITPR1 14525934 16237118 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA9 ITPR1 24234451 24947355 25348397 colocalization,physical association fluorescence microscopy,proximity ligation assay ComPPI,IntAct
PSMD2 ITPR1 25348397 N/A physical interaction ComPPI
BCL2 ITPR1 14525934 15613488 19706527 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
FYN ITPR1 14525934 14761954 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TRPC5 ITPR1 25348397 N/A physical interaction ComPPI
TRPC4 ITPR1 11163362 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TRIM25 ITPR1 25348397 N/A physical interaction ComPPI
PDE5A ITPR1 18757735 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CABP1 ITPR1 12032348 14525934 14570872 14685260 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AMFR ITPR1 25348397 N/A physical interaction ComPPI
BRCA1 ITPR1 25348397 25645916 27898060 N/A physical interaction ComPPI,OmniPath
AKT1 ITPR1 18250332 24234451 24947355 25348397 physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
PLK2 ITPR1 25348397 N/A physical interaction ComPPI
SYNPO ITPR1 25348397 N/A physical interaction ComPPI
ITPR1 ERP44 14525934 15652484 24234451 25348397 27898060 physical association coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
ITPR1 ITPRIP 14525934 16990268 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ITPR1 IRAG1 25348397 N/A physical interaction,in vivo ComPPI
ITPR1 AHCYL1 12525476 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ITPR1 ITPR3 14525934 25348397 27898060 7559486 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ITPR1 ERLIN2 17502376 19240031 25348397 25882839 27898060 N/A physical interaction ComPPI,OmniPath
ITPR1 UFD1 25348397 N/A physical interaction ComPPI
ITPR1 TESPA1 25348397 N/A physical interaction ComPPI
ITPR1 CAPZA2 25348397 N/A physical interaction ComPPI
ITPR1 GTF2H5 25348397 N/A physical interaction ComPPI
ITPR1 RNF170 25348397 N/A physical interaction ComPPI
ITPR1 CTDNEP1 25348397 N/A physical interaction ComPPI
ITPR1 RAB29 25348397 N/A physical interaction ComPPI
ITPR1 FBXL14 25348397 N/A physical interaction ComPPI
ITPR1 CRTC2 22495310 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITPR1 PPIF 24234451 24947355 25348397 physical association proximity ligation assay ComPPI,IntAct
CDK1 ITPR1 14525934 14635192 16237118 N/A experimental interaction detection HPRD
PLEC ITPR1 24234451 30021884 physical association cross-linking study IntAct
UBC ITPR1 10191279 16103111 16134970 21071436 21610068 22871113 27898060 N/A N/A OmniPath
PKD2 ITPR1 20375013 27898060 N/A N/A OmniPath
BECN1 ITPR1 19325567 27898060 N/A N/A OmniPath
PRKACA ITPR1 12529267 1847804 27898060 2847175 8132598 inhibition,stimulant N/A OmniPath
FYN ITPR1 14761954 18056410 27898060 stimulant N/A OmniPath
ITPR1 TRPC3 10518223 11524429 12606542 15104175 15623527 18205297 20022948 20378853 23045459 27898060 9853757 stimulant N/A OmniPath
AKT1 ITPR1 18250332 18955969 24947355 27898060 inhibition N/A OmniPath
CDK1 ITPR1 14635192 16237118 27898060 N/A N/A OmniPath
ITPRIPL1 ITPR1 21368195 27898060 stimulant N/A OmniPath

Visualization










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