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GENE：SPTLC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPTLC1
FullNmae serine palmitoyltransferase long chain base subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11277
EnsembleID ENSG00000090054
Uniprot O15269

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPTLC1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPTLC1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPTLC1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SPTLC1 GO:0004758,GO:0004758,GO:0005515,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0006665,GO:0006686,GO:0017059,GO:0017059,GO:0030148,GO:0030148,GO:0030170,GO:0035339,GO:0046511,GO:0046512,GO:0046512,GO:0046513,GO:0046513,GO:1904504,GO:1904649

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPTLC1 hsa:10558 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SPTLC1 hsa:10558 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SPTLC1 hsa:10558 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADRB2 SPTLC1 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 SPTLC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SPTLC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SPTLC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SPTLC1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SPTLC1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SPTLC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFEC1 SPTLC1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003380CC SPTLC1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 SPTLC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000116F83 SPTLC1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 SPTLC1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A939F SPTLC1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 SPTLC1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D SPTLC1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C SPTLC1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 SPTLC1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 SPTLC1 25354783 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ABL1 SPTLC1 22135298 phosphorylation N/A PhosphoSite
SPTLC1 ORMDL3 25361965 interaction type N/A PTMCode2
ORMDL3 SPTLC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 SPTLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R15A SPTLC1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN SPTLC1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
MYC SPTLC1 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CFTR SPTLC1 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK6 SPTLC1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ADRB2 SPTLC1 25348397 N/A physical interaction ComPPI
EGFR SPTLC1 25348397 N/A physical interaction ComPPI
JAK3 SPTLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SPTLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AUP1 SPTLC1 25348397 N/A physical interaction ComPPI
MAGED1 SPTLC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED12 SPTLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCA1 SPTLC1 14525934 18484747 24234451 25170080 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SPTLC2 SPTLC1 10713067 10722674 11781309 14525934 19416851 20182505 24234451 25348397 27898060 physical association experimental interaction detection,ubiquitin reconstruction,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SPTLC1 RGS20 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 RAB5IF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 ORMDL3 20182505 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 ATG4C 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 FBXO6 25348397 N/A physical interaction ComPPI
SPTLC1 TCEAL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 ARMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC1 GTF2IRD1 25348397 N/A physical interaction ComPPI
SPTLC1 FBXO32 25348397 N/A physical interaction ComPPI
SPTLC1 SPTLC3 19416851 24234451 25348397 association,physical association pull down,ubiquitin reconstruction,physical interaction ComPPI,IntAct
SPTLC1 SPTSSA 19416851 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SPTLC1 SPTSSB 19416851 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SPTLC1 UVRAG 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SPTLC1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SPTLC1 IFT27 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
ABL1 SPTLC1 23629659 27898060 inhibition N/A OmniPath

Visualization










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