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GENE：AMBRA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AMBRA1
FullNmae autophagy and beclin 1 regulator 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25990
EnsembleID ENSG00000110497
Uniprot Q9C0C7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AMBRA1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AMBRA1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
AMBRA1 GO:0000045,GO:0000045,GO:0000209,GO:0000422,GO:0000423,GO:0000423,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005776,GO:0005783,GO:0005829,GO:0005829,GO:0005856,GO:0005925,GO:0005930,GO:0006357,GO:0006914,GO:0007049,GO:0008285,GO:0009267,GO:0010508,GO:0010508,GO:0010667,GO:0019903,GO:0021915,GO:0030154,GO:0031625,GO:0035307,GO:0043161,GO:0043231,GO:0043524,GO:0043552,GO:0045335,GO:0045591,GO:0048471,GO:0051020,GO:0080008,GO:0098780,GO:0098780,GO:1901526,GO:1904544,GO:1990756,GO:2000045

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AMBRA1 hsa:55626 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa04140 Autophagy - animal - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa05010 Alzheimer disease - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa05016 Huntington disease - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
AMBRA1 hsa:55626 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2 AMBRA1 11704864 17446862 21358617 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
AMBRA1 BECN1 20417604 21358617 22441670 23030059 23180781 23377657 23974797 26192618 interaction type,physical association anti tag coimmunoprecipitation,two hybrid ACSN,InnateDB
PIK3C3 AMBRA1 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEDD8 AMBRA1 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL4A AMBRA1 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR AMBRA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AMBRA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 AMBRA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 AMBRA1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 AMBRA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 AMBRA1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 AMBRA1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 AMBRA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003FD55 AMBRA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC AMBRA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 AMBRA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002F74F1 AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000034979B AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CC864 AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000183BED AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003FBC84 AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006372A AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDA4 AMBRA1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MTOR AMBRA1 22135298 phosphorylation N/A PhosphoSite
PIK3C3 AMBRA1 25361965 interaction type N/A PTMCode2
AMBRA1 PIK3C3 25361965 interaction type N/A PTMCode2
AMBRA1 BECN1 25361965 interaction type N/A PTMCode2
BECN1 AMBRA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 AMBRA1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SOCS3 AMBRA1 25348397 N/A physical interaction ComPPI
HSPA8 AMBRA1 25348397 N/A physical interaction ComPPI
DYNLL2 AMBRA1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PSMC3 AMBRA1 25348397 N/A physical interaction ComPPI
PSMC6 AMBRA1 25348397 N/A physical interaction ComPPI
PPP2R1A AMBRA1 24234451 25348397 25438055 physical association anti tag coimmunoprecipitation,molecular sieving,physical interaction,tandem affinity purification ComPPI,IntAct
UBL4A AMBRA1 25348397 N/A physical interaction ComPPI
TRAF6 AMBRA1 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
PSMB2 AMBRA1 25348397 N/A physical interaction ComPPI
COPS5 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA3 AMBRA1 25348397 N/A physical interaction ComPPI
UBC AMBRA1 25348397 N/A physical interaction ComPPI
HSP90AA1 AMBRA1 25348397 N/A physical interaction ComPPI
ACTN1 AMBRA1 25348397 N/A physical interaction ComPPI
STIP1 AMBRA1 25348397 N/A physical interaction ComPPI
HSPA5 AMBRA1 25348397 N/A physical interaction ComPPI
CISH AMBRA1 25348397 N/A physical interaction ComPPI
PSMA1 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA6 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA5 AMBRA1 25348397 N/A physical interaction ComPPI
MYC AMBRA1 24234451 25348397 25438055 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DUSP4 AMBRA1 25348397 N/A physical interaction ComPPI
PPP2CA AMBRA1 24234451 25348397 25438055 physical association two hybrid,physical interaction ComPPI,IntAct
PSMD8 AMBRA1 25348397 N/A physical interaction ComPPI
PSMC5 AMBRA1 25348397 N/A physical interaction ComPPI
CUL4B AMBRA1 25348397 N/A physical interaction ComPPI
CUL4A AMBRA1 25348397 N/A physical interaction ComPPI
TUBA1A AMBRA1 25348397 N/A physical interaction ComPPI
PSMC4 AMBRA1 25348397 N/A physical interaction ComPPI
RNF2 AMBRA1 25348397 N/A physical interaction ComPPI
GABARAP AMBRA1 25348397 N/A physical interaction ComPPI
GPS1 AMBRA1 25348397 N/A physical interaction ComPPI
COPS8 AMBRA1 25348397 N/A physical interaction ComPPI
PSMD2 AMBRA1 25348397 N/A physical interaction ComPPI
ELOB AMBRA1 25348397 N/A physical interaction ComPPI
F12 AMBRA1 25348397 N/A physical interaction ComPPI
BCL2 AMBRA1 21358617 24234451 25348397 covalent binding,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,fluorescent resonance energy transfer,physical interaction,fluorescence microscopy ComPPI,IntAct
PRKN AMBRA1 25348397 N/A physical interaction ComPPI
PSMD10 AMBRA1 25348397 N/A physical interaction ComPPI
CUL7 AMBRA1 25348397 N/A physical interaction ComPPI
UBE2D3 AMBRA1 25348397 N/A physical interaction ComPPI
BECN1 AMBRA1 14525934 17589504 20562859 21358617 23954414 23974797 24234451 25348397 25438055 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PIK3C3 AMBRA1 25348397 N/A physical interaction ComPPI
PSMB5 AMBRA1 25348397 N/A physical interaction ComPPI
TRIM25 AMBRA1 25348397 N/A physical interaction ComPPI
WDR1 AMBRA1 25348397 N/A physical interaction ComPPI
DDB1 AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC1 AMBRA1 25348397 N/A physical interaction ComPPI
DNAJB1 AMBRA1 25348397 N/A physical interaction ComPPI
MTOR AMBRA1 25348397 N/A physical interaction ComPPI
STUB1 AMBRA1 25348397 N/A physical interaction ComPPI
NUDC AMBRA1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMB3 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA7 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA4 AMBRA1 25348397 N/A physical interaction ComPPI
ULK1 AMBRA1 23524951 24234451 25348397 25438055 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW11 AMBRA1 25348397 N/A physical interaction ComPPI
NES AMBRA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BAG2 AMBRA1 25348397 N/A physical interaction ComPPI
DCAF7 AMBRA1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
ATG3 AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR AMBRA1 23524951 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPD1 AMBRA1 25348397 N/A physical interaction ComPPI
SUGT1 AMBRA1 25348397 N/A physical interaction ComPPI
MAP1B AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ASB8 AMBRA1 25348397 N/A physical interaction ComPPI
PSMD13 AMBRA1 25348397 N/A physical interaction ComPPI
PSMD12 AMBRA1 25348397 N/A physical interaction ComPPI
TUBB3 AMBRA1 25348397 N/A physical interaction ComPPI
ATG4B AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC2 AMBRA1 25348397 N/A physical interaction ComPPI
PSMD6 AMBRA1 25348397 N/A physical interaction ComPPI
CCT4 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA2 AMBRA1 25348397 N/A physical interaction ComPPI
CCT2 AMBRA1 25348397 N/A physical interaction ComPPI
WSB2 AMBRA1 25348397 N/A physical interaction ComPPI
HPS1 AMBRA1 25348397 N/A physical interaction ComPPI
AMBRA1 USP50 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AMBRA1 ATG13 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
AMBRA1 DYNC1I1 25348397 N/A physical interaction ComPPI
AMBRA1 RFPL4B 25348397 N/A physical interaction ComPPI
AMBRA1 VPS50 25348397 N/A physical interaction ComPPI
AMBRA1 LRRC42 25348397 N/A physical interaction ComPPI
AMBRA1 TBC1D22A 25348397 N/A physical interaction ComPPI
AMBRA1 CAMKMT 25348397 N/A physical interaction ComPPI
AMBRA1 PRAMEF5 25348397 N/A physical interaction ComPPI
AMBRA1 HSP90AA2P 25348397 N/A physical interaction ComPPI
AMBRA1 CCT3 25348397 N/A physical interaction ComPPI
AMBRA1 CCT8 25348397 N/A physical interaction ComPPI
AMBRA1 MC1R 25348397 N/A physical interaction ComPPI
AMBRA1 PSMD3 25348397 N/A physical interaction ComPPI
AMBRA1 IRGM 25348397 N/A physical interaction ComPPI
AMBRA1 BECN2 23954414 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AMBRA1 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
TRIM10 AMBRA1 25348397 N/A physical interaction ComPPI
BAG5 AMBRA1 25348397 N/A physical interaction ComPPI
DDA1 AMBRA1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRRC29 AMBRA1 25348397 N/A physical interaction ComPPI
AMBRA1 AMBRA1 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
METTL3 AMBRA1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
ULK1 AMBRA1 20921139 23524951 27898060 stimulant N/A OmniPath
DYNLL2 AMBRA1 20921139 27898060 inhibition N/A OmniPath
BECN1 AMBRA1 17589504 20417604 20562859 20711182 20921139 21358617 23954414 23974797 24587252 25499913 27898060 stimulant N/A OmniPath
AMBRA1 BECN1 17589504 20417604 20562859 20711182 20921139 21358617 23954414 23974797 24587252 25499913 27898060 stimulant N/A OmniPath
DYNLL1 AMBRA1 20921139 27898060 inhibition N/A OmniPath
MTOR AMBRA1 23524951 27898060 N/A N/A OmniPath

Visualization










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