GENE:TLK2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | TLK2 |
FullNmae | tousled like kinase 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:11842 |
EnsembleID | ENSG00000146872 |
Uniprot | Q86UE8 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
TLK2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
TLK2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
TLK2 | GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005882,GO:0006325,GO:0006468,GO:0006974,GO:0007059,GO:0007059,GO:0010507,GO:0018105,GO:0018105,GO:0032435,GO:0035556,GO:0035556,GO:0042802,GO:0048471,GO:0048471,GO:0051647,GO:0071480,GO:0106310,GO:1902275 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | TLK2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
YBX1 | TLK2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
CEBPA | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP1 | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | TLK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000DDD35 | TLK2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00003E226A | TLK2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000044FD7 | TLK2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000029D9F1 | TLK2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005485E8 | TLK2 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS00007455B8 | TLK2 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000047A8F | TLK2 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GMCL1 | TLK2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
DYNLL1 | TLK2 | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
DYNLL2 | TLK2 | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
ASF1A | TLK2 | 25348397 | N/A | two hybrid,physical interaction,in vitro,in vivo | ComPPI |
IRF4 | TLK2 | 21903422 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
FEZ1 | TLK2 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
YWHAZ | TLK2 | 25348397 | N/A | in vivo | ComPPI |
RPS27A | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
NTRK1 | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
RPS6KA1 | TLK2 | 23455922 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
NFATC2 | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
FEZ2 | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
XPO1 | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
MBP | TLK2 | 25348397 | N/A | in vitro | ComPPI |
TLK2 | TLK1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
TLK2 | ASF1B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,physical interaction,in vitro,in vivo | ComPPI,IntAct |
TLK2 | AURKA | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | IRF7 | 21903422 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
TLK2 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | RFPL3 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | EID3 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | LHX6 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | STK24 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | SPATA1 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | CABIN1 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | IL36A | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | AMOTL1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TLK2 | IFFO1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TLK2 | CDADC1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TLK2 | SCML1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TLK2 | COBLL1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TLK2 | CEP70 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
TLK2 | PAX6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
TLK2 | PAX5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
XPO7 | TLK2 | 25348397 | N/A | physical interaction | ComPPI |
TLK2 | TLK2 | 24234451 | physical association | two hybrid array,two hybrid prey pooling approach | IntAct |
TLK2 | ASF1A | 11470414 20016786 26496610 27898060 | N/A | N/A | OmniPath |
IRF7 | TLK2 | 21903422 27898060 | N/A | N/A | OmniPath |