Gene Information gene info

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GENE：TLK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLK2
FullNmae tousled like kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11842
EnsembleID ENSG00000146872
Uniprot Q86UE8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLK2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TLK2 GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005882,GO:0006325,GO:0006468,GO:0006974,GO:0007059,GO:0007059,GO:0010507,GO:0018105,GO:0018105,GO:0032435,GO:0035556,GO:0035556,GO:0042802,GO:0048471,GO:0048471,GO:0051647,GO:0071480,GO:0106310,GO:1902275

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF4 TLK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TLK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TLK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 TLK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TLK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 TLK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E226A TLK2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 TLK2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 TLK2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00005485E8 TLK2 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00007455B8 TLK2 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000047A8F TLK2 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 TLK2 22135298 phosphorylation N/A PhosphoSite
TLK2 ASF1B 22135298 phosphorylation N/A PhosphoSite
TLK2 ASF1A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GMCL1 TLK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DYNLL1 TLK2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
DYNLL2 TLK2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
ASF1A TLK2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
IRF4 TLK2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FEZ1 TLK2 25348397 N/A two hybrid,physical interaction ComPPI
YWHAZ TLK2 25348397 N/A in vivo ComPPI
RPS27A TLK2 25348397 N/A physical interaction ComPPI
NTRK1 TLK2 25348397 N/A physical interaction ComPPI
RPS6KA1 TLK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NFATC2 TLK2 25348397 N/A physical interaction ComPPI
FEZ2 TLK2 25348397 N/A physical interaction ComPPI
XPO1 TLK2 25348397 N/A physical interaction ComPPI
MBP TLK2 25348397 N/A in vitro ComPPI
TLK2 TLK1 25348397 N/A physical interaction,in vivo ComPPI
TLK2 ASF1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
TLK2 AURKA 25348397 N/A physical interaction ComPPI
TLK2 IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLK2 ELAVL1 25348397 N/A physical interaction ComPPI
TLK2 RFPL3 25348397 N/A physical interaction ComPPI
TLK2 EID3 25348397 N/A physical interaction ComPPI
TLK2 LHX6 25348397 N/A physical interaction ComPPI
TLK2 STK24 25348397 N/A physical interaction ComPPI
TLK2 SPATA1 25348397 N/A physical interaction ComPPI
TLK2 CABIN1 25348397 N/A physical interaction ComPPI
TLK2 IL36A 25348397 N/A physical interaction ComPPI
TLK2 AMOTL1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TLK2 IFFO1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TLK2 CDADC1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TLK2 SCML1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TLK2 COBLL1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TLK2 CEP70 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLK2 PAX6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLK2 PAX5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPO7 TLK2 25348397 N/A physical interaction ComPPI
TLK2 TLK2 24234451 physical association two hybrid array,two hybrid prey pooling approach IntAct
TLK2 ASF1A 11470414 20016786 26496610 27898060 N/A N/A OmniPath
IRF7 TLK2 21903422 27898060 N/A N/A OmniPath

Visualization










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