GENE：CPS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CPS1 |
| FullNmae | carbamoyl-phosphate synthase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2323 |
| EnsembleID | ENSG00000021826 |
| Uniprot | P31327 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CPS1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CPS1 | GO:0000050,GO:0000050,GO:0004087,GO:0004087,GO:0004088,GO:0004175,GO:0005509,GO:0005515,GO:0005524,GO:0005543,GO:0005730,GO:0005737,GO:0005743,GO:0005759,GO:0005886,GO:0006207,GO:0006541,GO:0007494,GO:0009410,GO:0009636,GO:0010043,GO:0014075,GO:0016595,GO:0019240,GO:0019433,GO:0030955,GO:0032094,GO:0032496,GO:0032991,GO:0036094,GO:0042311,GO:0042594,GO:0042645,GO:0043200,GO:0044344,GO:0044877,GO:0046209,GO:0046872,GO:0050667,GO:0055081,GO:0060416,GO:0070365,GO:0070409,GO:0071242,GO:0071320,GO:0071377,GO:0071400,GO:0071548,GO:0072341 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CPS1 | hsa:1373 | path:hsa00220 | Arginine biosynthesis - Homo sapiens (human) |
| CPS1 | hsa:1373 | path:hsa00250 | Alanine, aspartate and glutamate metabolism - Homo sapiens (human) |
| CPS1 | hsa:1373 | path:hsa00910 | Nitrogen metabolism - Homo sapiens (human) |
| CPS1 | hsa:1373 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CPS1 | hsa:1373 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
| CPS1 | hsa:1373 | path:hsa01230 | Biosynthesis of amino acids - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CPS1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | CPS1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | CPS1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | CPS1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CPS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CPS1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002075FA | CPS1 | 23313552 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS000052EA98 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023133F | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CC709 | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BCD9C | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ECFE5 | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000184017 | CPS1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032FC1A | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A9CF | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006A1CB | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000050CCE0 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000017CCCB | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003BF62 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035CC3E | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005481D | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EE7F0 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000030F801 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008DA94 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000260A3A | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000038718E | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | CPS1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSPA8 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| PCBP1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| RAD21 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| FOXG1 | CPS1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ARAF | CPS1 | 12620389 14525934 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| YWHAZ | CPS1 | 15161933 20618440 24234451 25348397 | association,physical association | pull down,tandem affinity purification | ComPPI,IntAct |
| TUBG1 | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| UBC | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA5 | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HSPA1A | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1B | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| DNAJC7 | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| YWHAQ | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| LMO2 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| RAF1 | CPS1 | 12620389 14525934 24234451 25348397 | physical association | two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| HSPA4 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPH1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA9 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| LRPPRC | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| H2AX | CPS1 | 20000738 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NDUFS7 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| OTC | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| KRT1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| XRCC3 | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SEC22B | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| AP1S2 | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| AGO2 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| RICTOR | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| CPT1A | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| TUBA1C | CPS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPS26 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| ALB | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM70 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO6 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| FH | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| TOMM70 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| TCF4 | CPS1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ASB1 | CPS1 | 25348397 | N/A | physical interaction | ComPPI |
| TANK | CPS1 | 24234451 30561431 | association | virotrap | IntAct |