GENE：SCOC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SCOC |
| FullNmae | short coiled-coil protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:20335 |
| EnsembleID | ENSG00000153130 |
| Uniprot | Q9UIL1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SCOC | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SCOC | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SCOC | GO:0000139,GO:0005515,GO:0005654,GO:0005768,GO:0005794,GO:0005802,GO:0005802,GO:0005829,GO:0016239,GO:0061635 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SCOC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | SCOC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SCOC | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | SCOC | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SCOC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | SCOC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000F0F49 | SCOC | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000285DCB | SCOC | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C83DA | SCOC | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BF7F9 | SCOC | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024CEE0 | SCOC | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005DEC41 | SCOC | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | SCOC | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | SCOC | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237E04 | SCOC | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | SCOC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015D23B | SCOC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C0D3F | SCOC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000215483 | SCOC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040780F | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006A1CB | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000202460 | SCOC | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GCC1 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| BFSP2 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| MAP1LC3B | SCOC | 22354037 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| KRT40 | SCOC | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MAPK8 | SCOC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FEZ1 | SCOC | 14525934 16484223 22354037 24234451 25348397 | colocalization | two hybrid,physical interaction,fluorescence microscopy,two hybrid | ComPPI,HPRD,IntAct |
| NRBF2 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| PAWR | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| FEZ2 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| RBBP8 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| SNAPIN | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| EPB41L3 | SCOC | 24234451 24366813 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ITSN1 | SCOC | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | ARL1 | 11303027 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SCOC | TCF4 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| SCOC | HNRNPH1 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | DOK5 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | EURL | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | ATG16L1 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | BLOC1S2 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | NUMA1 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | CCHCR1 | 25348397 | N/A | physical interaction | ComPPI |
| SCOC | ETS1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| SCOC | TGOLN2 | 22354037 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |