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GENE：EIF2AK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF2AK4
FullNmae eukaryotic translation initiation factor 2 alpha kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19687
EnsembleID ENSG00000128829
Uniprot Q9P2K8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF2AK4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF2AK4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EIF2AK4 GO:0000049,GO:0000077,GO:0002230,GO:0002250,GO:0002286,GO:0002821,GO:0004674,GO:0004694,GO:0004694,GO:0004694,GO:0004694,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006446,GO:0006468,GO:0007049,GO:0007612,GO:0007616,GO:0010998,GO:0010998,GO:0010998,GO:0019081,GO:0022626,GO:0032057,GO:0032792,GO:0034198,GO:0034644,GO:0036492,GO:0044828,GO:0045665,GO:0045947,GO:0046777,GO:0051607,GO:0060259,GO:0070417,GO:0071264,GO:0106310,GO:0140469,GO:0140469,GO:0140469,GO:1900273,GO:1990138,GO:1990253,GO:1990625

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF2AK4 hsa:440275 path:hsa04140 Autophagy - animal - Homo sapiens (human)
EIF2AK4 hsa:440275 path:hsa05160 Hepatitis C - Homo sapiens (human)
EIF2AK4 hsa:440275 path:hsa05162 Measles - Homo sapiens (human)
EIF2AK4 hsa:440275 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EIF2AK4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EIF2AK4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF2AK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EIF2AK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF2AK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EIF2AK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF2AK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C7662 EIF2AK4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B EIF2AK4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039D790 EIF2AK4 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EIF2AK4 GCN1 25361965 interaction type N/A PTMCode2
GCN1 EIF2AK4 25361965 interaction type N/A PTMCode2
EIF2S1 EIF2AK4 25361965 interaction type N/A PTMCode2
EIF2AK4 EIF2S1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPP1CC EIF2AK4 25348397 N/A physical interaction ComPPI
PSMC3 EIF2AK4 25348397 N/A physical interaction ComPPI
NUDCD3 EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SMAD4 EIF2AK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 EIF2AK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STIP1 EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PPP1CA EIF2AK4 25348397 N/A physical interaction ComPPI
CACYBP EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HNRNPL EIF2AK4 25348397 N/A physical interaction ComPPI
EWSR1 EIF2AK4 16189514 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MDM4 EIF2AK4 25348397 N/A physical interaction ComPPI
TRAP1 EIF2AK4 25348397 N/A physical interaction ComPPI
ARRB2 EIF2AK4 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD2 EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
LRPPRC EIF2AK4 25348397 N/A physical interaction ComPPI
CDC37 EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BAG2 EIF2AK4 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
EIF2AK4 USP46 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2AK4 CROT 25348397 N/A physical interaction ComPPI
EIF2AK4 TARS1 25348397 N/A physical interaction ComPPI
EIF2AK4 MATR3 25348397 N/A physical interaction ComPPI
EIF2AK4 DEF8 25348397 N/A physical interaction ComPPI
EIF2AK4 TKT 25348397 N/A physical interaction ComPPI
EIF2AK4 PALM2 25348397 N/A physical interaction ComPPI
EIF2AK4 C6ORF141 25348397 N/A physical interaction ComPPI
EIF2AK4 CRYL1 25348397 N/A physical interaction ComPPI
EIF2AK4 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
EIF2AK4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ITGB1 EIF2AK4 24234451 30021884 physical association cross-linking study IntAct
GCN1 EIF2AK4 10775272 10801780 11350982 19448108 21849502 27898060 N/A N/A OmniPath
EIF2AK4 EIF2S1 15355306 15550948 27898060 inhibition,stimulant N/A OmniPath
EIF2AK4 EIF2A 16595687 25329545 27898060 inhibition,stimulant N/A OmniPath
PRKDC EIF2AK4 19451221 27898060 inhibition N/A OmniPath
DNAJC3 EIF2AK4 25329545 27898060 inhibition N/A OmniPath
EIF2AK4 MARS1 22106287 27898060 inhibition N/A OmniPath

Visualization










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