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GENE：PIP4K2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIP4K2B
FullNmae phosphatidylinositol-5-phosphate 4-kinase type 2 beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8998
EnsembleID ENSG00000276293
Uniprot P78356

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIP4K2B lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PIP4K2B lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIP4K2B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIP4K2B autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIP4K2B autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIP4K2B GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0005886,GO:0007166,GO:0010506,GO:0010506,GO:0016308,GO:0016308,GO:0016309,GO:0016310,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:1902635,GO:2000786

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIP4K2B hsa:8396 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIP4K2B hsa:8396 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIP4K2B hsa:8396 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIP4K2B hsa:8396 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PIP4K2B 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 PIP4K2B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000F31F4 PIP4K2B 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PIP4K2B 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C308D PIP4K2B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PIP4K2B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075BDA4 PIP4K2B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D PIP4K2B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA PIP4K2B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 PIP4K2B 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 PIP4K2B 22135298 phosphorylation N/A PhosphoSite
TNFRSF1A PIP4K2B 25361965 interaction type N/A PTMCode2
PIP4K2B TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LIN7A PIP4K2B 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP19 PIP4K2B 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LZTS2 PIP4K2B 25348397 N/A physical interaction ComPPI
SKP1 PIP4K2B 25348397 N/A physical interaction ComPPI
BTK PIP4K2B 14525934 14614850 15046600 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFRSF1A PIP4K2B 14525934 25348397 27898060 9038203 9753329 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CLK1 PIP4K2B 25348397 N/A physical interaction ComPPI
ZRANB2 PIP4K2B 25348397 N/A physical interaction ComPPI
CSNK2A2 PIP4K2B 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EPB41L3 PIP4K2B 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBQLN4 PIP4K2B 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PIP4K2B SPOP 18218622 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PIP4K2B HMBOX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIP4K2B ARL6IP4 25348397 N/A physical interaction ComPPI
PIP4K2B EAF1 25348397 N/A physical interaction ComPPI
PIP4K2B DDX23 25348397 N/A physical interaction ComPPI
PIP4K2B MYL9 25348397 N/A physical interaction ComPPI
PIP4K2B PRPF8 25348397 N/A physical interaction ComPPI
PIP4K2B MED4 25348397 N/A physical interaction ComPPI
PIP4K2B PIP4K2A 25348397 N/A physical interaction ComPPI
PIP4K2B HIF1AN 24234451 25348397 29426014 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIP4K2B ARHGAP22 25348397 N/A physical interaction ComPPI
PIP4K2B AHCYL2 25348397 N/A physical interaction ComPPI
PIP4K2B GPBP1L1 25348397 N/A physical interaction ComPPI
PIP4K2B SPRY4 25348397 N/A physical interaction ComPPI
PIP4K2B PRICKLE3 25348397 N/A physical interaction ComPPI
PIP4K2B ZNF428 25348397 N/A physical interaction ComPPI
PIP4K2B TULP3 25348397 N/A physical interaction ComPPI
PIP4K2B NEMP1 25348397 N/A physical interaction ComPPI
PIP4K2B SUN2 25348397 N/A physical interaction ComPPI
PIP4K2B RNPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MED18 PIP4K2B 25348397 N/A physical interaction ComPPI
PIP4K2B PIP4K2B 14525934 9753329 N/A experimental interaction detection HPRD
MAPK14 PIP4K2B 16949365 27898060 inhibition N/A OmniPath

Visualization










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